Staci L Sudenga1, Alan G Nyitray2, B Nelson Torres3, Roberto Silva4, Luisa Villa5, Eduardo Lazcano-Ponce6, Martha Abrahamsen3, Maria Luiza Baggio6, Jorge Salmeron7, Manuel Quiterio7, Anna R Giuliano8. 1. Center for Infection Research in Cancer, Moffitt Cancer Center, Tampa, FL, USA; Division of Epidemiology, Vanderbilt University, Nashville, TN, USA. 2. Center for Infectious Disease, The University of Texas School of Public Health at Houston, TX, USA. 3. Center for Infection Research in Cancer, Moffitt Cancer Center, Tampa, FL, USA. 4. Centro de Referência e Treinamento em DST/AIDS, São Paulo, Brazil. 5. School of Medicine, Universidade de São Paulo, São Paulo, Brazil. 6. Center for Translational Investigation in Oncology, Instituto do Câncer do Estado de São Paulo, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil. 7. Instituto Nacional de Salud Pública, Cuernavaca, Mexico. 8. Center for Infection Research in Cancer, Moffitt Cancer Center, Tampa, FL, USA. Electronic address: Anna.Giuliano@Moffitt.org.
Abstract
OBJECTIVES: Globally, anal cancer incidence is rare, but is increasing in some world regions. Our objective was to assess differences in anal HPV natural history in three countries. METHODS: Men aged 18-70 years were recruited from the US (n = 634), Mexico (n = 665), and Brazil (n = 731). Anal specimens were collected every six-months. HPV genotyping was assessed by Linear Array. Anal HPV prevalence was compared using the Fisher's exact test. HPV infection incidence rates (IR) and 95% confidence intervals (CI) were calculated. RESULTS: Any anal HPV prevalence was highest among men from Brazil (24%) compared to Mexico (15%) and the US (15%). When stratified by sexual history, the prevalence of any HPV among MSM/MSMW was 43%, 37%, and 45% and 9%, 12%, and 10% for MSW from Brazil, Mexico, and US, respectively. Any HPV incidence was significantly higher among men from Brazil compared to US men (IRR = 2.4, 95% CI = 1.7-3.4) and comparable between men from Mexico and the US (IRR = 1.2, 95% CI = 0.8-1.8). CONCLUSION: Men in Brazil and Mexico often have similar, if not higher incidence of anal HPV compared to men from the U.S., and may benefit from gender neutral HPV vaccine policies.
OBJECTIVES: Globally, anal cancer incidence is rare, but is increasing in some world regions. Our objective was to assess differences in anal HPV natural history in three countries. METHODS:Men aged 18-70 years were recruited from the US (n = 634), Mexico (n = 665), and Brazil (n = 731). Anal specimens were collected every six-months. HPV genotyping was assessed by Linear Array. Anal HPV prevalence was compared using the Fisher's exact test. HPV infection incidence rates (IR) and 95% confidence intervals (CI) were calculated. RESULTS: Any anal HPV prevalence was highest among men from Brazil (24%) compared to Mexico (15%) and the US (15%). When stratified by sexual history, the prevalence of any HPV among MSM/MSMW was 43%, 37%, and 45% and 9%, 12%, and 10% for MSW from Brazil, Mexico, and US, respectively. Any HPV incidence was significantly higher among men from Brazil compared to US men (IRR = 2.4, 95% CI = 1.7-3.4) and comparable between men from Mexico and the US (IRR = 1.2, 95% CI = 0.8-1.8). CONCLUSION:Men in Brazil and Mexico often have similar, if not higher incidence of anal HPV compared to men from the U.S., and may benefit from gender neutral HPV vaccine policies.
Authors: Deepti Bettampadi; Luisa L Villa; Eduardo L Ponce; Jorge Salmeron; Bradley A Sirak; Martha Abrahamsen; Julie A Rathwell; Richard R Reich; Anna R Giuliano Journal: Int J Cancer Date: 2019-11-01 Impact factor: 7.396
Authors: Neide Aparecida Tosato Boldrini; Lays Paula Bondi Volpini; Luciana Bueno de Freitas; Carlos Musso; Paulo Roberto Merçon de Vargas; Liliana Cruz Spano; Angelica Espinosa Miranda Journal: PLoS One Date: 2018-07-05 Impact factor: 3.240
Authors: Ryan D Assaf; Marjan Javanbakht; Elissa Meites; Beau Gratzer; Martin Steinau; Richard A Crosby; Lauri E Markowitz; Elizabeth R Unger; Pamina M Gorbach Journal: Sex Transm Dis Date: 2020-07 Impact factor: 3.868