Literature DB >> 28362503

Direct Catalytic Asymmetric Reductive Amination of Aliphatic Ketones Utilizing Diphenylmethanamine as Coupling Partner.

Haizhou Huang1, Yunfei Zhao1, Yang Yang1, Le Zhou1, Mingxin Chang1.   

Abstract

The highly efficient direct catalytic reductive amination of ketones with diphenylmethanamine catalyzed by iridium-phosphoramidite complexes is described. As an effective coupling partner, diphenylmethanamine is suitable for a wide range of ketones to provide chiral amines in high yields and enantioselectivity. The chiral monodentate phosphoramidite ligands are tunable and competent to accommodate substrates with different structures.

Entities:  

Year:  2017        PMID： 28362503     DOI： 10.1021/acs.orglett.7b00212

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  4 in total

1.  Iridium-catalyzed direct asymmetric reductive amination utilizing primary alkyl amines as the N-sources.

Authors:  Zitong Wu; Wenji Wang; Haodong Guo; Guorui Gao; Haizhou Huang; Mingxin Chang
Journal:  Nat Commun       Date:  2022-06-10       Impact factor: 17.694

2.  The combination of asymmetric hydrogenation of olefins and direct reductive amination.

Authors:  Shuai Yuan; Guorui Gao; Lili Wang; Cungang Liu; Lei Wan; Haizhou Huang; Huiling Geng; Mingxin Chang
Journal:  Nat Commun       Date:  2020-01-30       Impact factor: 14.919

3.  Direct Asymmetric Reductive Amination for the Synthesis of (S)-Rivastigmine.

Authors:  Guorui Gao; Shaozhi Du; Yang Yang; Xue Lei; Haizhou Huang; Mingxin Chang
Journal:  Molecules       Date:  2018-08-31       Impact factor: 4.411

4.  Secondary amines as coupling partners in direct catalytic asymmetric reductive amination.

Authors:  Zitong Wu; Shaozhi Du; Guorui Gao; Wenkun Yang; Xiongyu Yang; Haizhou Huang; Mingxin Chang
Journal:  Chem Sci       Date:  2019-03-14       Impact factor: 9.825
  4 in total

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