Yash R Patel1, Taraka V Gadiraju2, R Curtis Ellison3, Steven C Hunt4, John Jeffrey Carr5, Gerardo Heiss6, Donna K Arnett7, James S Pankow8, J Michael Gaziano9, Luc Djoussé9. 1. Division of Aging, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, United States. Electronic address: dryashpatel21@gmail.com. 2. Division of Aging, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, United States; Tulane Heart & Vascular Institute, Tulane University School of Medicine, New Orleans, LA, United States. 3. Section of Preventive Medicine & Epidemiology, Boston University, Boston, MA, United States. 4. Department of Genetic Medicine, Weill Cornell Medicine, Doha, Qatar; Cardiovascular Genetics Division, University of Utah School of Medicine, Salt Lake City, UT, United States. 5. Department of Radiology, Cardiovascular Medicine and Biomedical Informatics, Vanderbilt University Medical Center Nashville, TN, United States. 6. Department of Epidemiology, School of Public Health, The University of North Carolina at Chapel Hill, NC, United States. 7. Division of Epidemiology, University of Alabama, Birmingham, AL, United States. 8. Division of Epidemiology, University of Minnesota, Minneapolis, MN, United States. 9. Division of Aging, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, United States; Massachusetts Veterans Epidemiology and Research Information Center (MAVERIC) and Geriatric Research, Education, and Clinical Research Center (GRECC), Boston Veterans Affairs Healthcare System, Boston, MA, United States.
Abstract
BACKGROUND & AIMS: While a recent meta-analysis of prospective studies reported that coffee consumption is associated with a lower risk of cardiovascular disease mortality, limited and inconsistent data are available on the relation of coffee intake with subclinical disease. Thus, the aim of the present study was to see the association of coffee consumption with the prevalence of atherosclerotic plaque in the coronary arteries in NHLBI Family Heart Study. METHODS: In a cross-sectional design, we studied 1929 participants of the NHLBI Family Heart Study without known coronary heart disease. Coffee consumption was assessed by a semi-quantitative food frequency questionnaire and coronary-artery calcium (CAC) was measured by cardiac computed tomography. We defined prevalent CAC as an Agatston score of ≥100 and used generalized estimating equations to calculate prevalence ratios of CAC as well as a sensitivity analysis at a range of cutpoints for CAC. RESULTS: Mean age was 56.7 years and 59% of the study subjects were female. In adjusted analysis for age, sex, BMI, smoking, alcohol, physical activity, field center, and energy intake, prevalence ratio (95% CI) for CAC was 1.0 (reference), 0.92 (0.57-1.49), 1.34 (0.86-2.08), 1.30 (0.84-2.02), and 0.99 (0.60-1.64) for coffee consumption of almost never, <1/day, 1/day, 2-3/day, and ≥4 cups/day, respectively. In a sensitivity analysis, there was no evidence of association between coffee consumption and prevalent CAC when CAC cut points of 0, 50, 150, 200, and 300 were used. CONCLUSIONS: These data do not provide evidence for an association between coffee consumption and prevalent CAC in adult men and women.
BACKGROUND & AIMS: While a recent meta-analysis of prospective studies reported that coffee consumption is associated with a lower risk of cardiovascular disease mortality, limited and inconsistent data are available on the relation of coffee intake with subclinical disease. Thus, the aim of the present study was to see the association of coffee consumption with the prevalence of atherosclerotic plaque in the coronary arteries in NHLBI Family Heart Study. METHODS: In a cross-sectional design, we studied 1929 participants of the NHLBI Family Heart Study without known coronary heart disease. Coffee consumption was assessed by a semi-quantitative food frequency questionnaire and coronary-artery calcium (CAC) was measured by cardiac computed tomography. We defined prevalent CAC as an Agatston score of ≥100 and used generalized estimating equations to calculate prevalence ratios of CAC as well as a sensitivity analysis at a range of cutpoints for CAC. RESULTS: Mean age was 56.7 years and 59% of the study subjects were female. In adjusted analysis for age, sex, BMI, smoking, alcohol, physical activity, field center, and energy intake, prevalence ratio (95% CI) for CAC was 1.0 (reference), 0.92 (0.57-1.49), 1.34 (0.86-2.08), 1.30 (0.84-2.02), and 0.99 (0.60-1.64) for coffee consumption of almost never, <1/day, 1/day, 2-3/day, and ≥4 cups/day, respectively. In a sensitivity analysis, there was no evidence of association between coffee consumption and prevalent CAC when CAC cut points of 0, 50, 150, 200, and 300 were used. CONCLUSIONS: These data do not provide evidence for an association between coffee consumption and prevalent CAC in adult men and women.
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