| Literature DB >> 28361419 |
N S Fattakhov1,2, D A Skuratovskaya3, M A Vasilenko3, E V Kirienkova3, P A Zatolokin4, N I Mironyuk4, L S Litvinova3.
Abstract
We studied association of single nucleotide polymorphism Glu298Asp (rs1799983) of the NOS3 gene with the risk of metabolic syndrome in the Slavic population. Blood samples were obtained from 128 patients with metabolic syndrome and 100 healthy individuals. Polymorphism Glu298Asp of the NOS3 gene was genotyped by allele-specific PCR. Allele Asp (OR=1.95, 95%CI 1.29-2.95, p=0.007) and genotype Asp/Asp (OR=2.56, 95%CI 0.98-6.72, p=0.04) were associated with the risk of metabolic syndrome in Slavic population. Patients with metabolic syndrome carrying genotype Asp/Asp had higher serum endothelin-1 level in comparison with Glu/Asp and Glu/Glu carriers.Entities:
Keywords: endothelial NO synthase; endothelial dysfunction; metabolic syndrome; nitric oxide; single nucleotide polymorphism
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Year: 2017 PMID： 28361419 DOI： 10.1007/s10517-017-3670-9
Source DB: PubMed Journal: Bull Exp Biol Med ISSN： 0007-4888 Impact factor: 0.804