Literature DB >> 28361415

Role of Vascular Endothelial Growth Factor and Transforming Growth Factor-β2 in Rat Bone Tissue after Bone Fracture and Placement of Titanium Implants with Bioactive Bioresorbable Coatings.

S G Kalinichenko1,2, N Yu Matveeva3,4, R E Kostiv3, A V Puz'4.   

Abstract

The study established enhanced expression of vascular endothelial growth factor (VEGF) in the subpopulation of osteoblasts located in the regeneration region of femoral bone fracture near the titanium implants with bioactive calcium phosphate and hydroxyapatite coatings and suppressed activity of transforming growth factor-β2 (TGF-β2) in chondroblasts during the two weeks after surgery. In the delayed posttraumatic period, the distribution of TGF-β2 inversely related to its maximal activity. The data revealed the up-regulating effect of bioresorbable coatings on expression of VEGF and TGF-β2 and their implication in the control over various stages of reparative osteogenesis.

Entities:  

Keywords:  bioactive nanoscale materials; bone tissue remodeling; morphogenetic factors

Mesh：

Substances：

Year:  2017        PMID： 28361415     DOI： 10.1007/s10517-017-3684-3

Source DB:  PubMed          Journal:  Bull Exp Biol Med        ISSN： 0007-4888            Impact factor:   0.804


  6 in total

1.  Localization of VEGF, TGF-β1, BMP-2, and Apoptosis Factors in Hypertrophic Nonunion of Human Tubular Bones.

Authors:  R E Kostiv; N Yu Matveeva; S G Kalinichenko
Journal:  Bull Exp Biol Med       Date:  2022-05-28       Impact factor: 0.804

2.  On-Bone Fixation of Free Gingival Graft Induces an Osteoinductive Effect in Human Alveolar Bone.

Authors:  S S Edranov; N Yu Matveeva; S G Kalinichenko
Journal:  Bull Exp Biol Med       Date:  2021-12-02       Impact factor: 0.804

3.  Dynamics of Renewal of Cell Populations of the Bone Tissue on the Surface of Titanium Implants with Bioactive Coating during Fracture Modeling in Rats.

Authors:  N Yu Matveeva; S G Kalinichenko; R E Kostiv
Journal:  Bull Exp Biol Med       Date:  2021-09-22       Impact factor: 0.804

4.  Osteogenic and Regenerative Potential of Free Gingival Graft.

Authors:  S S Edranov; N Yu Matveeva; S G Kalinichenko
Journal:  Bull Exp Biol Med       Date:  2021-07-22       Impact factor: 0.804

5.  A Transcriptome-Level Study Identifies Changing Expression Profiles for Ossification of the Ligamentum Flavum of the Spine.

Authors:  Yawei Han; Yuheng Hong; Liandong Li; Tengshuai Li; Zhen Zhang; Jingzhao Wang; Han Xia; Yutao Tang; Zhemin Shi; Xiaohui Han; Ting Chen; Qi Liu; Mengxia Zhang; Kun Zhang; Wei Hong; Yuan Xue
Journal:  Mol Ther Nucleic Acids       Date:  2018-08-07       Impact factor: 8.886

6.  A pilot study of circulating levels of TGF-β1 and TGF-β2 as biomarkers of bone healing in patients with non-hypertrophic pseudoarthrosis of long bones.

Authors:  Daniel Chaverri; Daniel Vivas; Santiago Gallardo-Villares; Fernando Granell-Escobar; Javier A Pinto; Joaquim Vives
Journal:  Bone Rep       Date:  2021-12-09
  6 in total

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