Literature DB >> 28361322

In Vivo Model of Small Intestine.

Maxime M Mahe1,2, Nicole E Brown1, Holly M Poling1, Michael A Helmrath3,4.   

Abstract

The utilization of human pluripotent stem cells (hPSCs) offers new avenues in the generation of organs and opportunities to understand development and diseases. The hPSC-derived human intestinal organoids (HIOs) provide a new tool to gain insights in small intestinal development, physiology, and associated diseases. Herein, we provide a method for orthotropic transplantation of HIOs in immunocompromised mice. This method highlights the specific steps to successful engraftment and provides insight into the study of bioengineered human small intestine.

Entities:  

Keywords:  Bioengineered small intestine; Human intestinal organoids; In vivo model; Kidney capsule; Mesentery; Pluripotent stem cells; Transplantation

Mesh：

Year:  2017        PMID： 28361322      PMCID： PMC5559894          DOI： 10.1007/978-1-4939-6949-4_17

Source DB:  PubMed          Journal:  Methods Mol Biol        ISSN： 1064-3745


  20 in total

1.  Functional engraftment of colon epithelium expanded in vitro from a single adult Lgr5⁺ stem cell.

Authors:  Shiro Yui; Tetsuya Nakamura; Toshiro Sato; Yasuhiro Nemoto; Tomohiro Mizutani; Xiu Zheng; Shizuko Ichinose; Takashi Nagaishi; Ryuichi Okamoto; Kiichiro Tsuchiya; Hans Clevers; Mamoru Watanabe
Journal:  Nat Med       Date:  2012-03-11       Impact factor: 53.440

2.  Human gut-on-a-chip inhabited by microbial flora that experiences intestinal peristalsis-like motions and flow.

Authors:  Hyun Jung Kim; Dongeun Huh; Geraldine Hamilton; Donald E Ingber
Journal:  Lab Chip       Date:  2012-03-20       Impact factor: 6.799

3.  Generating human intestinal tissue from pluripotent stem cells in vitro.

Authors:  Kyle W McCracken; Jonathan C Howell; James M Wells; Jason R Spence
Journal:  Nat Protoc       Date:  2011-11-10       Impact factor: 13.491

Review 4.  Intestinal development and differentiation.

Authors:  Taeko K Noah; Bridgitte Donahue; Noah F Shroyer
Journal:  Exp Cell Res       Date:  2011-09-24       Impact factor: 3.905

5.  Human and mouse tissue-engineered small intestine both demonstrate digestive and absorptive function.

Authors:  Christa N Grant; Salvador Garcia Mojica; Frederic G Sala; J Ryan Hill; Daniel E Levin; Allison L Speer; Erik R Barthel; Hiroyuki Shimada; Nicholas C Zachos; Tracy C Grikscheit
Journal:  Am J Physiol Gastrointest Liver Physiol       Date:  2015-01-08       Impact factor: 4.052

6.  Sustained in vitro intestinal epithelial culture within a Wnt-dependent stem cell niche.

Authors:  Akifumi Ootani; Xingnan Li; Eugenio Sangiorgi; Quoc T Ho; Hiroo Ueno; Shuji Toda; Hajime Sugihara; Kazuma Fujimoto; Irving L Weissman; Mario R Capecchi; Calvin J Kuo
Journal:  Nat Med       Date:  2009-04-27       Impact factor: 53.440

7.  Contributions of microbiome and mechanical deformation to intestinal bacterial overgrowth and inflammation in a human gut-on-a-chip.

Authors:  Hyun Jung Kim; Hu Li; James J Collins; Donald E Ingber
Journal:  Proc Natl Acad Sci U S A       Date:  2015-12-14       Impact factor: 11.205

Review 8.  Generating human intestinal tissues from pluripotent stem cells to study development and disease.

Authors:  Katie L Sinagoga; James M Wells
Journal:  EMBO J       Date:  2015-03-19       Impact factor: 14.012

9.  Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro.

Authors:  Jason R Spence; Christopher N Mayhew; Scott A Rankin; Matthew F Kuhar; Jefferson E Vallance; Kathryn Tolle; Elizabeth E Hoskins; Vladimir V Kalinichenko; Susanne I Wells; Aaron M Zorn; Noah F Shroyer; James M Wells
Journal:  Nature       Date:  2010-12-12       Impact factor: 49.962

10.  An in vivo model of human small intestine using pluripotent stem cells.

Authors:  Carey L Watson; Maxime M Mahe; Jorge Múnera; Jonathan C Howell; Nambirajan Sundaram; Holly M Poling; Jamie I Schweitzer; Jefferson E Vallance; Christopher N Mayhew; Ying Sun; Gregory Grabowski; Stacy R Finkbeiner; Jason R Spence; Noah F Shroyer; James M Wells; Michael A Helmrath
Journal:  Nat Med       Date:  2014-10-19       Impact factor: 87.241
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  6 in total

Review 1.  Engineering a second brain in a dish.

Authors:  Maxime M Mahe
Journal:  Brain Res       Date:  2018-08-15       Impact factor: 3.252

2.  In Vivo Transplantation of Human Intestinal Organoids Enhances Select Tight Junction Gene Expression.

Authors:  Mariaelena A Boyle; David J Sequeira; Eoin P McNeill; Zachary K Criss; Noah F Shroyer; Allison L Speer
Journal:  J Surg Res       Date:  2020-11-07       Impact factor: 2.192

3.  Mechanically induced development and maturation of human intestinal organoids in vivo.

Authors:  Holly M Poling; David Wu; Nicole Brown; Michael Baker; Taylor A Hausfeld; Nhan Huynh; Samuel Chaffron; James C Y Dunn; Simon P Hogan; James M Wells; Michael A Helmrath; Maxime M Mahe
Journal:  Nat Biomed Eng       Date:  2018-06-04       Impact factor: 29.234

Review 4.  Human small intestinal organotypic culture model for drug permeation, inflammation, and toxicity assays.

Authors:  Jan Markus; Tim Landry; Zachary Stevens; Hailey Scott; Pierre Llanos; Michelle Debatis; Alexander Armento; Mitchell Klausner; Seyoum Ayehunie
Journal:  In Vitro Cell Dev Biol Anim       Date:  2020-11-25       Impact factor: 2.416

5.  Transplantation of human intestinal organoids into the mouse mesentery: A more physiologic and anatomic engraftment site.

Authors:  Alexander R Cortez; Holly M Poling; Nicole E Brown; Akaljot Singh; Maxime M Mahe; Michael A Helmrath
Journal:  Surgery       Date:  2018-07-30       Impact factor: 4.348

6.  Evaluation of transplantation sites for human intestinal organoids.

Authors:  Akaljot Singh; Holly M Poling; Nambirajan Sundaram; Nicole Brown; James M Wells; Michael A Helmrath
Journal:  PLoS One       Date:  2020-08-27       Impact factor: 3.240
  6 in total

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