Literature DB >> 28360348

Contemporary Approaches to Modulating the Nitric Oxide-cGMP Pathway in Cardiovascular Disease.

Jan R Kraehling1, William C Sessa2.   

Abstract

Endothelial cells lining the vessel wall control important aspects of vascular homeostasis. In particular, the production of endothelium-derived nitric oxide and activation of soluble guanylate cyclase promotes endothelial quiescence and governs vasomotor function and proportional remodeling of blood vessels. Here, we discuss novel approaches to improve endothelial nitric oxide generation and preserve its bioavailability. We also discuss therapeutic opportunities aimed at activation of soluble guanylate cyclase for multiple cardiovascular indications.
© 2017 American Heart Association, Inc.

Entities:  

Keywords:  caveolin-1; endothelial cells; heart failure; nitrates; nitric oxide

Mesh：

Substances：

Year:  2017        PMID： 28360348      PMCID： PMC5391494          DOI： 10.1161/CIRCRESAHA.117.303776

Source DB:  PubMed          Journal:  Circ Res        ISSN： 0009-7330            Impact factor:   17.367


  106 in total

1.  A functional domain of the alpha1 subunit of soluble guanylyl cyclase is necessary for activation of the enzyme by nitric oxide and YC-1 but is not involved in heme binding.

Authors:  Markus Koglin; Sönke Behrends
Journal:  J Biol Chem       Date:  2003-01-30       Impact factor: 5.157

2.  Cerebral microvascular nNOS responds to lowered oxygen tension through a bumetanide-sensitive cotransporter and sodium-calcium exchanger.

Authors:  Holly D Bauser-Heaton; Jin Song; H Glenn Bohlen
Journal:  Am J Physiol Heart Circ Physiol       Date:  2008-03-07       Impact factor: 4.733

Review 3.  AKAPs: the architectural underpinnings of local cAMP signaling.

Authors:  Michael D Kritzer; Jinliang Li; Kimberly Dodge-Kafka; Michael S Kapiloff
Journal:  J Mol Cell Cardiol       Date:  2011-05-11       Impact factor: 5.000

4.  A cell-based cGMP assay useful for ultra-high-throughput screening and identification of modulators of the nitric oxide/cGMP pathway.

Authors:  Frank Wunder; Johannes-Peter Stasch; Joachim Hütter; Cristina Alonso-Alija; Jörg Hüser; Emanuel Lohrmann
Journal:  Anal Biochem       Date:  2005-04-01       Impact factor: 3.365

5.  Cinaciguat, a soluble guanylate cyclase activator: results from the randomized, controlled, phase IIb COMPOSE programme in acute heart failure syndromes.

Authors:  Mihai Gheorghiade; Stephen J Greene; Gerasimos Filippatos; Erland Erdmann; Roberto Ferrari; Phillip D Levy; Aldo Maggioni; Christina Nowack; Alexandre Mebazaa
Journal:  Eur J Heart Fail       Date:  2012-06-19       Impact factor: 15.534

6.  5-hydroxytryptamine evokes endothelial nitric oxide synthase activation in bovine aortic endothelial cell cultures.

Authors:  J E McDuffie; S D Coaxum; M A Maleque
Journal:  Proc Soc Exp Biol Med       Date:  1999-09

7.  The Golgi association of endothelial nitric oxide synthase is necessary for the efficient synthesis of nitric oxide.

Authors:  W C Sessa; G García-Cardeña; J Liu; A Keh; J S Pollock; J Bradley; S Thiru; I M Braverman; K M Desai
Journal:  J Biol Chem       Date:  1995-07-28       Impact factor: 5.157

8.  Selective inhibition of tumor microvascular permeability by cavtratin blocks tumor progression in mice.

Authors:  Jean Philippe Gratton; Michelle I Lin; Jun Yu; Erik D Weiss; Zao Li Jiang; Todd A Fairchild; Yasuko Iwakiri; Roberto Groszmann; Kevin P Claffey; Yung Chi Cheng; William C Sessa
Journal:  Cancer Cell       Date:  2003-07       Impact factor: 31.743

9.  Evidence for enhanced vascular superoxide anion production in nitrate tolerance. A novel mechanism underlying tolerance and cross-tolerance.

Authors:  T Münzel; H Sayegh; B A Freeman; M M Tarpey; D G Harrison
Journal:  J Clin Invest       Date:  1995-01       Impact factor: 14.808

10.  Caveolin-1 influences vascular protease activity and is a potential stabilizing factor in human atherosclerotic disease.

Authors:  Juan A Rodriguez-Feo; Willem E Hellings; Frans L Moll; Jean-Paul P M De Vries; Ben J van Middelaar; Ale Algra; Joost Sluijter; Evelyn Velema; Theo van den Broek; William C Sessa; Dominique P V De Kleijn; Gerard Pasterkamp
Journal:  PLoS One       Date:  2008-07-02       Impact factor: 3.240
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  20 in total

1.  Activation of Kv 7 channels as a novel mechanism for NO/cGMP-induced pulmonary vasodilation.

Authors:  Gema Mondéjar-Parreño; Javier Moral-Sanz; Bianca Barreira; Alicia De la Cruz; Teresa Gonzalez; Maria Callejo; Sergio Esquivel-Ruiz; Daniel Morales-Cano; Laura Moreno; Carmen Valenzuela; Francisco Perez-Vizcaino; Angel Cogolludo
Journal:  Br J Pharmacol       Date:  2019-05-11       Impact factor: 8.739

Review 2.  Leveraging Signaling Pathways to Treat Heart Failure With Reduced Ejection Fraction.

Authors:  Miguel Pinilla-Vera; Virginia S Hahn; David A Kass
Journal:  Circ Res       Date:  2019-05-24       Impact factor: 17.367

3.  Loss of smooth muscle CYB5R3 amplifies angiotensin II-induced hypertension by increasing sGC heme oxidation.

Authors:  Brittany G Durgin; Scott A Hahn; Heidi M Schmidt; Megan P Miller; Neha Hafeez; Ilka Mathar; Daniel Freitag; Peter Sandner; Adam C Straub
Journal:  JCI Insight       Date:  2019-10-03

Review 4.  The Role of Nitroglycerin and Other Nitrogen Oxides in Cardiovascular Therapeutics.

Authors:  Sanjay Divakaran; Joseph Loscalzo
Journal:  J Am Coll Cardiol       Date:  2017-11-07       Impact factor: 24.094

5.  Smooth muscle cell CYB5R3 preserves cardiac and vascular function under chronic hypoxic stress.

Authors:  Brittany G Durgin; Katherine C Wood; Scott A Hahn; Brenda McMahon; Jeffrey J Baust; Adam C Straub
Journal:  J Mol Cell Cardiol       Date:  2021-09-15       Impact factor: 5.000

6.  Impact of cigarette smoking on nitric oxide-sensitive and nitric oxide-insensitive soluble guanylate cyclase-mediated vascular tone regulation.

Authors:  Masashi Tawa; Takeshi Kinoshita; Takayoshi Masuoka; Yuka Yamashita; Katsuya Nakano; Matomo Nishio; Tomio Okamura; Takaharu Ishibashi
Journal:  Hypertens Res       Date:  2019-11-29       Impact factor: 3.872

Review 7.  Endothelial NOS: perspective and recent developments.

Authors:  Victor Garcia; William C Sessa
Journal:  Br J Pharmacol       Date:  2018-12-09       Impact factor: 8.739

8.  Aortic disease in Marfan syndrome is caused by overactivation of sGC-PRKG signaling by NO.

Authors:  Andrea de la Fuente-Alonso; Marta Toral; Alvaro Alfayate; María Jesús Ruiz-Rodríguez; Elena Bonzón-Kulichenko; Gisela Teixido-Tura; Sara Martínez-Martínez; María José Méndez-Olivares; Dolores López-Maderuelo; Ileana González-Valdés; Eusebio Garcia-Izquierdo; Susana Mingo; Carlos E Martín; Laura Muiño-Mosquera; Julie De Backer; J Francisco Nistal; Alberto Forteza; Arturo Evangelista; Jesús Vázquez; Miguel R Campanero; Juan Miguel Redondo
Journal:  Nat Commun       Date:  2021-05-11       Impact factor: 14.919

9.  Modeling NO Biotransport in Brain Using a Space-Fractional Reaction-Diffusion Equation.

Authors:  Andrew Tamis; Corina S Drapaca
Journal:  Front Physiol       Date:  2021-06-25       Impact factor: 4.566

Review 10.  Hypertension, dietary salt and cognitive impairment.

Authors:  Monica M Santisteban; Costantino Iadecola
Journal:  J Cereb Blood Flow Metab       Date:  2018-10-08       Impact factor: 6.960
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