Ângela Cristine Bersch-Ferreira1, Geni Rodrigues Sampaio2, Marcella Omena Gehringer2, Maria Beatriz Ross-Fernandes2, Cristiane Kovacs3, Renata Alves4, Jaqueline Lopes Pereira2, Carlos Daniel Magnoni3, Bernardete Weber5, Marcelo Macedo Rogero6. 1. Department of Nutrition, School of Public Health, University of São Paulo, São Paulo, Brazil; Research Institute, Hospital do Coracção (IP-HCor), São Paulo, SP, Brazil. 2. Department of Nutrition, School of Public Health, University of São Paulo, São Paulo, Brazil. 3. Department of Clinical Nutrition at Instituto Dante Pazzanese de Cardiologia, São Paulo, Brazil. 4. Department of Nutrition, School of Public Health, University of São Paulo, São Paulo, Brazil; Department of Clinical Nutrition at Instituto Dante Pazzanese de Cardiologia, São Paulo, Brazil. 5. Research Institute, Hospital do Coracção (IP-HCor), São Paulo, SP, Brazil. 6. Department of Nutrition, School of Public Health, University of São Paulo, São Paulo, Brazil. Electronic address: mmrogero@usp.br.
Abstract
OBJECTIVE: The aim of this study was to assess the association between polyunsaturated fatty acids (PUFAs) and inflammatory biomarkers among patients in secondary prevention of cardiovascular disease (CVD). METHODS: In this cross-sectional substudy from BALANCE Program Trial, we have collected data from 364 patients with established CVD. Twenty-four-hour dietary recalls and plasma FA concentrations were analyzed to estimate the FA intake. Inflammatory biomarkers measurement consisted of interleukin (IL)-1β, IL-6, IL-8, IL-10, IL-12, C-reactive protein, adiponectin, and tumor necrosis factor-α. After log-transformation of inflammatory biomarkers, multivariate-adjusted general linear model was used to examine the effect of FA intake. The association was adjusted for body mass index, waist circumference, energy, smoking status, age, total cholesterol, low-density lipoprotein cholesterol, physical activity, and calcium channel blockers. RESULTS: PUFAs were inversely associated with C-reactive protein levels (P = 0.006) and with IL-1 β. The increase of 1 g/1000 kcal in PUFAs, omega-3, and omega-6 reduces, on average, 6%, 48%, and 8% respectively, the mean concentration of IL-1 β. CONCLUSION: Omega-3 and omega-6 FA intakes are inversely associated with inflammatory biomarkers among CVD patients. Additional studies on omega-3 and omega-6 intake in relation to inflammatory biomarkers in patients in secondary prevention of CVD are needed, particularly regarding dietary patterns that are rich in some sources of PUFA.
OBJECTIVE: The aim of this study was to assess the association between polyunsaturated fatty acids (PUFAs) and inflammatory biomarkers among patients in secondary prevention of cardiovascular disease (CVD). METHODS: In this cross-sectional substudy from BALANCE Program Trial, we have collected data from 364 patients with established CVD. Twenty-four-hour dietary recalls and plasma FA concentrations were analyzed to estimate the FA intake. Inflammatory biomarkers measurement consisted of interleukin (IL)-1β, IL-6, IL-8, IL-10, IL-12, C-reactive protein, adiponectin, and tumor necrosis factor-α. After log-transformation of inflammatory biomarkers, multivariate-adjusted general linear model was used to examine the effect of FA intake. The association was adjusted for body mass index, waist circumference, energy, smoking status, age, total cholesterol, low-density lipoprotein cholesterol, physical activity, and calcium channel blockers. RESULTS:PUFAs were inversely associated with C-reactive protein levels (P = 0.006) and with IL-1 β. The increase of 1 g/1000 kcal in PUFAs, omega-3, and omega-6 reduces, on average, 6%, 48%, and 8% respectively, the mean concentration of IL-1 β. CONCLUSION:Omega-3 and omega-6 FA intakes are inversely associated with inflammatory biomarkers among CVD patients. Additional studies on omega-3 and omega-6 intake in relation to inflammatory biomarkers in patients in secondary prevention of CVD are needed, particularly regarding dietary patterns that are rich in some sources of PUFA.
Authors: Jessica L Krok-Schoen; Theodore M Brasky; Rebecca P Hunt; Thomas E Rohan; Tamara A Baker; Wenjun Li; Laura Carbone; Rachel H Mackey; Linda Snetselaar; Maryam B Lustberg; Marian L Neuhouser Journal: J Acad Nutr Diet Date: 2018-06-18 Impact factor: 4.910
Authors: Luke J Peppone; Julia E Inglis; Karen M Mustian; Charles E Heckler; Gilbert D A Padula; Supriya G Mohile; Charles S Kamen; Eva Culakova; Po-Ju Lin; Sarah L Kerns; Sharon Cole; Michelle C Janelsins Journal: JNCI Cancer Spectr Date: 2019-02-21