Literature DB >> 2835836

Topical antibiotics in chronic sickle cell leg ulcers.

K F Baum1, D E MacFarlane, G H Maude, G R Serjeant.   

Abstract

A randomized, controlled, trial of a topical antibiotic preparation (neomycin, bacitracin, and polymyxin B) was performed in 30 patients with homozygous sickle cell (SS) disease and chronic leg ulceration. Over a period of 8 weeks, the reduction in ulcer size was significantly (P less than 0.05) greater in the treatment group than in the control group. The results suggest that these topical antibiotics may contribute to the therapy of chronic leg ulceration associated with sickle cell disease.

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Year:  1987        PMID： 2835836     DOI： 10.1016/0035-9203(87)90049-6

Source DB:  PubMed          Journal:  Trans R Soc Trop Med Hyg        ISSN： 0035-9203            Impact factor:   2.184


  9 in total

1.  Microbial flora and its significance in pathology of sickle cell disease leg ulcers.

Authors:  S C Sehgal; B K Arunkumar
Journal:  Infection       Date:  1992 Mar-Apr       Impact factor: 3.553

2.  Topical sodium nitrite for chronic leg ulcers in patients with sickle cell anaemia: a phase 1 dose-finding safety and tolerability trial.

Authors:  Caterina P Minniti; Alexander M Gorbach; Dihua Xu; Yuen Yi Hon; Kara-Marie Delaney; Miles Seidel; Nitin Malik; Marlene Peters-Lawrence; Carly Cantilena; James S Nichols; Laurel Mendelsohn; Anna Conrey; George Grimes; Gregory J Kato
Journal:  Lancet Haematol       Date:  2014-12-01       Impact factor: 18.959

3.  Red blood cell transfusion to treat or prevent complications in sickle cell disease: an overview of Cochrane reviews.

Authors:  Patricia M Fortin; Sally Hopewell; Lise J Estcourt
Journal:  Cochrane Database Syst Rev       Date:  2018-08-01

Review 4.  Interventions for treating leg ulcers in people with sickle cell disease.

Authors:  Arturo J Martí-Carvajal; Jennifer M Knight-Madden; Maria José Martinez-Zapata
Journal:  Cochrane Database Syst Rev       Date:  2021-01-09

Review 5.  Leg Ulcers in Sickle-Cell Disease: Treatment Update.

Authors:  Jean-Benoît Monfort; Patricia Senet
Journal:  Adv Wound Care (New Rochelle)       Date:  2019-04-24       Impact factor: 4.730

Review 6.  Beyond the definitions of the phenotypic complications of sickle cell disease: an update on management.

Authors:  Samir K Ballas; Muge R Kesen; Morton F Goldberg; Gerard A Lutty; Carlton Dampier; Ifeyinwa Osunkwo; Winfred C Wang; Carolyn Hoppe; Ward Hagar; Deepika S Darbari; Punam Malik
Journal:  ScientificWorldJournal       Date:  2012-08-01

Review 7.  A treatment algorithm to identify therapeutic approaches for leg ulcers in patients with sickle cell disease.

Authors:  Igor A Altman; Raymond E Kleinfelder; John G Quigley; William J Ennis; Caterina P Minniti
Journal:  Int Wound J       Date:  2015-11-04       Impact factor: 3.315

8.  Insights into the skin microbiome of sickle cell disease leg ulcers.

Authors:  Julia Byeon; Katherine D Blizinsky; Anitra Persaud; Keisha Findley; Jung-Jin Lee; Ashley J Buscetta; Shuo You; Kyle Bittinger; Caterina P Minniti; Vence L Bonham; Elizabeth A Grice
Journal:  Wound Repair Regen       Date:  2021-05-08       Impact factor: 3.401

Review 9.  Interventions for treating leg ulcers in people with sickle cell disease.

Authors:  Arturo J Martí-Carvajal; Jennifer M Knight-Madden; Maria José Martinez-Zapata
Journal:  Cochrane Database Syst Rev       Date:  2014-12-08
  9 in total

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