Literature DB >> 28356325

Return on investment of public health interventions: a systematic review.

Rebecca Masters1,2, Elspeth Anwar2,3,4, Brendan Collins2,4, Richard Cookson5, Simon Capewell2.   

Abstract

BACKGROUND: Public sector austerity measures in many high-income countries mean that public health budgets are reducing year on year. To help inform the potential impact of these proposed disinvestments in public health, we set out to determine the return on investment (ROI) from a range of existing public health interventions.
METHODS: We conducted systematic searches on all relevant databases (including MEDLINE; EMBASE; CINAHL; AMED; PubMed, Cochrane and Scopus) to identify studies that calculated a ROI or cost-benefit ratio (CBR) for public health interventions in high-income countries.
RESULTS: We identified 2957 titles, and included 52 studies. The median ROI for public health interventions was 14.3 to 1, and median CBR was 8.3. The median ROI for all 29 local public health interventions was 4.1 to 1, and median CBR was 10.3. Even larger benefits were reported in 28 studies analysing nationwide public health interventions; the median ROI was 27.2, and median CBR was 17.5.
CONCLUSIONS: This systematic review suggests that local and national public health interventions are highly cost-saving. Cuts to public health budgets in high income countries therefore represent a false economy, and are likely to generate billions of pounds of additional costs to health services and the wider economy. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

Entities:  

Keywords:  ECONOMICS; Economic evaluation; Health inequalities; PUBLIC HEALTH; PUBLIC HEALTH POLICY

Mesh:

Year:  2017        PMID: 28356325      PMCID: PMC5537512          DOI: 10.1136/jech-2016-208141

Source DB:  PubMed          Journal:  J Epidemiol Community Health        ISSN: 0143-005X            Impact factor:   3.710


Introduction

Benjamin Franklin once famously stated that “an ounce of prevention is worth a pound of cure”. Long-term pressures on public sector costs due to demographic and technological changes and cost inflation in the caring professions have intensified following the 2008 global financial crisis. Public health is often considered a politically soft target for budget cuts, as recently demonstrated by major budget reductions in the UK.1–3 The benefits of population-level public health expenditure—unlike those of personal healthcare and social care expenditure—tend to be long term, mostly accruing after the current politicians and policymakers have moved on. Though large and certain at the population level, benefits are also seen as small and uncertain for individual voters. It is therefore important to take a hard look at the cost-effective evidence, and move towards more rational decision-making in this politically charged area. Return on investment (ROI) and cost-benefit ratio (CBR) are two forms of economic evaluation that value the financial return, or benefits, of an intervention against the total costs of its delivery. The CBR is the benefit divided by the cost, and the ROI is the benefit minus the cost expressed as a proportion of the cost, that is, the CBR−1. To help inform the discussion of proposed cuts to public health budgets, we set out to determine the ROI and opportunity cost for a range of public health interventions at the local and national levels. The theory underpinning this review is that, because political backing for public health intervention is often lacking, many interventions with a high ROI are not funded. This is because public health interventions are often opposed by powerful commercial interests, and the health gains for individuals are often perceived as too small to sway their voting intentions, despite adding up to large gains at the population level.4

Methods

We conducted a systematic review to examine the ROI of public health interventions delivered in high-income countries with universal healthcare. These included the UK, Western Europe, the USA, Canada, Japan, Australia and New Zealand.

Search strategy

The authors used Acheson's definition of public health when considering our search strategy: “The science and art of promoting and protecting health and well-being, preventing ill-health and prolonging life through the organised efforts of society”.5 This definition is purposefully broad and the authors felt that it would incorporate the various fields of public health. We searched the PubMed, MEDLINE, Scopus, CINAHL, Cochrane, PsycInfo and AMED databases using the following search terms: ‘public health’ (all fields) AND ‘return on investment’ OR ‘cost benefit analysis’ (title or abstract). We also hand searched the references of the included analyses to identify any further studies. A grey literature search was completed using Google, yielding three additional results. Limits were set to publications in the English language, and to interventions targeted at humans (where applicable). Studies with poor generalisability to the UK were excluded, including a number from the USA that may poorly reflect UK healthcare systems, structure and demographics.

Study selection and inclusion criteria

We included studies of any design that reported a ROI of public health interventions delivered in industrialised countries providing universal healthcare.

Selection of articles and extraction of data

One investigator (RM) performed the initial screening of the titles. A second reviewer (EA) independently reviewed the titles and potentially relevant abstracts. The results were cross-referenced and any disagreements were discussed with a third reviewer (BC). One investigator (RM) led the data extraction and quality assessment, which was then independently duplicated by EA. A third reviewer (BC) adjudicated on any disagreements regarding result details or quality assessment. RM contacted authors for additional data in three cases, with two responses.

Assessment of methodological quality in included studies

The methodological quality of each included study was assessed independently by two reviewers (RM and EA) using the National Institute for Health and Care Excellence (NICE) quality appraisal checklist for economic evaluations to assess the quality and external validity of each study.6 Disagreements in methodological quality assessments for all the included studies were resolved by consensus or by recourse to a third member of the review team (BC).

Results

We identified 2957 potentially relevant titles, after excluding 2559 duplicates. A further 2816 papers were excluded following title or abstract review. We finally included 52 relevant titles published over four decades (see online supplementary figure S1). Results were stratified by public health specialty (table 1), and by interventions at a local level (table 2) or national level (table 3). Results were reported in five different currencies, as detailed in tables 2 and 3.
Table 1

ROI of public health programmes overall, and stratified by level and specialism

Median ROIROI rangeNumber of ROI studiesMedian CBRCBR rangeNumber of CBR studies
Overall 14.3 –21.3 to 22134 8.3 0.7 to 29.423
Local level 4.1 0.9 to 19.318 10.3 0.9 to 23.611
National level 27.2 –21.3 to 22117 17 1.2 to 167.10
Specialism
Health protection 34.2 0.7 to 2218 41.8 1.1 to 16710
Legislation 46.5 38 to 552 5.8 3 to 8.62
Health promotion 2.2 0.7 to 6.212 14.4 2 to 29.43
Healthcare public health 5.1 1.1 to 19.36None reportedNone reportedNone reported
Wider determinants 5.6 1.1 to 10.86 7.1 0.7 to 23.66

CBR, cost-benefit ratio; ROI, return on investment.

Table 2

Return on investment of local public health programmes: specific studies

ReferenceInterventionPopulationBenefit-cost ratioReturn on investmentCost perspectiveDiscount rateTime horizonStudy quality
Andresen et al 31 Supervised injection facilitiesIDU population of Vancouver, Canada5.12Medical and societal3%Lifetime++
Arrieta et al 18 Home blood pressure monitoring for hypertension diagnosis and treatment16 375 participants, USA$7.50–$19.35Insurer3%10 years++
Baker et al 44 Workplace obesity management890 employees, USA$1–$1.17MedicalNone1 year
Beard et al 41 Community-based falls prevention2000 cases and 1600 matched controls, Australia20.6Medical and societal8%18 months++
Collins42 Smoking cessationPopulation of Wirral, UK£1.77Medical3.5%20 years++
Dopp et al 57 Multisystematic therapy with serious juvenile offenders and their siblings305 participants, USA5.04Medical and societal3%25 years++
Goetzel et al 45 Workplace health risk management programme for small businesses2458 employees, USA$2.03Medical and productivityNo1 year
Guo et al 59 Improved walking and cycling infrastructure4674 participants, USA1.87Medical3%10 years++
Kleitz et al 21 Multisystematic therapy with serious juvenile offenders176 participants, USA9.51–23.59Medical and societal3%13.7 years++
Kuehl et al 46 Workplace health promotion for fire fighters1369 fire fighters, USA$4.61Medical and insurerNone7 years
Long et al 47 Health promotion programme for hospital staff4402 hospital staff, USA$2.87EmployerNone1–4 years+
Moore et al 52 Medication management for high-risk groups4500 health plan participants, USA$2InsurerNone1 year
Medivil et al 60 Speed cameras in urban settingsBarcelona, Spain€6.80Medical and societal3%2 years++
Nelson et al 39 Water fluoridationPopulation of Houston, Texas$1.51Societal10%10 years++
Nyman et al 22 Workplace health promotion1757 cases and 3619 matched controls, employer, USA$0.87No2 years+
Ozminkowski et al 51 Workplace health management25 931 Citibank employees$4.61Insurer4%3.2 years++
Peters et al 9 20 mph zones in LondonPopulation of London, UK0.66–2.19Societal3.5%10 years++
Reynolds et al 20 Intensive early education programme for socioeconomically deprived families (preschool programme)1539 participants, USA$10.83Medical and societal3%20 years++
Reynolds et al 20 Intensive early education programme for socioeconomically deprived families (school age programme)850 participants, USA$3.97Medical and societal3%20 years++
Reynolds et al 20 Intensive early education programme for socioeconomically deprived families (extended intervention)553 participants, USA$8.24Medical and societal3%20 years++
Richard et al 43 Tobacco cessation805 Medicaid insured tobacco users, USA$2–$2.25InsurerNone1.3 years
Rundell et al 53 Therapeutic services for alcoholism3034 Oklahoma alcohol service users, USA$1.98Medical and legal4%10 and 22 years++
Schwartz et al 48 Wellness and disease prevention programme57 940 health insurance clients, USA$2.02InsurerNone8 years
Schweinhart et al 56 Preschool education programme for socioeconomically deprived children123 preschool children, USA7.16Medical and societal3%40 years
Steinbach et al 19 20 mph zones in LondonPopulation of London, UK£1.12MedicalNone10 years
Spence et al 54 Outpatient pharmacy services for medication adherence2957 matched cases and controls, USA$5.97Medical and productivityNone1 year
Van Vonno et al 17 Heart failure disease management1360 matched cases and controls, USA$1.15InsurerNone1 year
Wang et al 61 Bike and pedestrian trails225 351 individual uses of bike and pedestrian trails over a 1 year period, USA$2.94Public healthNone10 years
Windsor et al 49 Antinatal stop smoking services994 pregnant smokers in Alabama, USA6.72–17.18MedicalNone5 years
Table 3

Return on investment of national public health programmes: specific studies

ReferenceInterventionPopulationBenefit-cost ratioReturn on investmentCost perspectiveDiscount rateTime horizonStudy quality
Abelson et al 10 Hib vaccinationAustralia1.06Medical5%15 years++
Abelson et al 10 HIV/AIDS preventionAustralia4Medical5%25 years++
Abelson et al 10 Measles vaccinationAustralia167Medical5%33 years++
Abelson et al 10 Programmes to reduce rates of coronary heart diseaseAustralia11Medical5%40 years++
Abelson et al 10 Programmes to reduce tobacco consumptionAustralia2Medical5%40 years++
Abelson et al 10 Road safety campaignsAustralia3Medical5%40 years++
Boccalini et al 32 Universal hepatitis B vaccinationItaly€2.78Medical and societal3%20 years++
Bonin et al 58 Parenting programmes for the prevention of persistent conduct disordersEngland7.89Medical and societal3.5%35 years++
Drummond11 Needle exchangeAustralia1.2Public health5%Lifetime++
Evans-Lacko et al 12 Antistigma social marketing campaignEngland£0.7 to £1.90UnclearNone1 year-
Garpenholt et al 38 Hib vaccinationSweden1.59Societal5%20 years++
Gortmaker et al 15 Sugar sweetened beverage taxUSA$55Medical3%10 years++
Gortmaker et al 15 Eliminating tax subsidy of nutritionally poor food advertising to childrenUSA$38Medical3%10 years++
Gould8 Lead paint controlUSA$17 to $221Medical and societalNoneUnclear
Holtgrave et al 34 HIV counselling, testing, referral and partner notification servicesUSA20.09Societal6%Lifetime++
Hutchinson et al 35 Expanded HIV testingUSA$1.46 to $2.01Health sector3%Lifetime++
Kwon et al 36 Needle exchangeAustralia$A1.3 to $A5.5Health sector3%Lifetime++
Lokkerbol et al 55 Telemedicine for depressionThe Netherlands€1.45 to €1.76Medical1.5% costs, 4% effects5 years++
McGuire et al 14 Family planning servicesUK11.09 to 29.39Medical6%Lifetime++
Miller et al 16 Booster seats for 4–7 years oldsUSA8.6Medical3%3 years++
Nguyen et al 37 Needle exchangeUSA$3.48MedicalNone1 year+
Nichol et al 7 Influenza vaccination of healthy workersUSA $21.27 to +$174.32Societal3%1 year+
Romano et al 40 Folic acid fortification of grainUSA4.3 to 6.1Human capital4%Lifetime++
Trust for America13 Primary and secondary prevention programmesUSA$6.2Medical0%10–20 years+
Wang et al 50 Universal school nursing servicesUSA$2.20SocietalNone1 year+
White et al 28 MMR vaccinationUSA14Medical10%Lifetime++
Ding et al 30 Hospital-based postpartum influenza vaccinationUSA$1.7Medical and societal3%1 year++
Zhou et al 38 Hib vaccinationUSA5.4Medical and societal3%Lifetime++

Hib, haemophilus influenzae type b; MMR, measles, mumps and rubella.

ROI of public health programmes overall, and stratified by level and specialism CBR, cost-benefit ratio; ROI, return on investment. Return on investment of local public health programmes: specific studies Return on investment of national public health programmes: specific studies Hib, haemophilus influenzae type b; MMR, measles, mumps and rubella. The median ROI for all public health interventions was 14.3, and the median CBR was 8.3. The reported ROI and CBRs ranged widely. The ROIs ranged from –21.27 (influenza vaccination of healthy workers7) to 221 (lead paint control8). The CBRs reported ranged from 0.66 (20 mph zones in low-impact areas9) to 167 (single measles vaccinations10). Studies reporting ROIs at the extreme end of the spectrum tended to be of poorer quality. Studies reporting a CBR tended to be higher quality.

ROI of public health programmes stratified by specialism

Analysis by specialism revealed that health protection and legislative interventions generally yielded high returns on investment, often being delivered on a national basis and only requiring a one-off intervention (such as a vaccination or a new tax). In contrast, interventions for healthcare public health, health promotion or wider determinants typically had lower returns, being often more complex, resource intensive and sustained. Figure 1 provides overviews of the median, maximum and minimum ROI by specialism, and figure 2 provides an overview of the median, maximum and minimum and CBR values stratified by specialism.
Figure 1

Median, maximum and minimum return on investment values stratified by specialism.

Figure 2

Median, maximum and minimum cost:benefit ratios stratified by specialism.

Median, maximum and minimum return on investment values stratified by specialism. Median, maximum and minimum cost:benefit ratios stratified by specialism.

Health protection interventions

Eighteen studies reported a large ROI in relation to health protection. The ROI median was 34.2, and ranged from −21.37 to 2218, and the CBR median was 41.8 (range from 1.211 to 16710).

Health promotion interventions

Fifteen health promotion interventions were reported, 12 ROI studies and 3 CBR studies. Returns on investment were variable. The median ROI was 2.2 (range 0.712 to 6.213). The median CBR was much higher at 14.4 (range 210 to 29.414).

Legislative interventions

Four studies reported on legislative interventions, with substantial returns. The median ROI was 46.5 (range 3815 to 5515). The median CBR was 5.8 (range 310 to 8.616).

Healthcare public health interventions

Six studies reported ROIs in relation to healthcare public health interventions. The ROI median was 5.1, and ranged from 1.1517 to 19.35.18 No studies reported a CBR.

Wider determinants interventions

Twelve studies reported a return on wider determinants interventions (for instance, targeted at children or juvenile offenders). The median ROI was 5.6 (range 1.119 to 10.820) with a median CBR of 7.1 (range 0.667 to 23.621).

ROI of public health interventions by level

A total of 29 studies reported returns on investment or CBRs in relation to local public health interventions. The median ROI was 4.1, and ranged from −0.922 to 19.3.18 The median CBR was 10.3 (range −0.77 to 23.619). There were 28 studies reporting on national public health interventions. The median ROI was 27.2 and ranged from −21.37 to 221.8 The median CBR was 17.5 (range 1.211 to 1678).

Discussion

Our systematic review offers several potentially important observations

First, even with the most rudimentary economic evaluations, it was clear that most public health interventions are substantially cost saving. This confirms our theory that public health interventions generally offer a considerable ROI. Median ROI was generally higher than median CBR in all of our key public health expenditure categories. This was because most studies only report one of these two measures, and studies that report ROI tend to have higher estimates. A direct comparison is possible, by converting between ROI and CBR at the study level using the simple formula ROI=CBR−1. Second, we demonstrated a public health ‘effectiveness hierarchy’. Public health interventions at a local level averaged an impressive ROI of 4, meaning that every pound invested yields a return of £4 plus the original investment back. However, ‘upstream’ interventions delivered on a national scale generally achieve even greater returns on investment, particularly legislation (a 10-fold higher ROI averaging 46). Third, Benjamin Franklin's belief that “an ounce of prevention is worth a pound of cure” is thus borne out by the costs-savings demonstrated, particularly when compared with recent returns for investment in healthcare.23 It has been estimated that investing an additional £13 000 in the English National Health Service (NHS) can achieve health benefits of one additional quality-adjusted life year (QALY).23 When this health benefit is valued in monetary terms at the UK Department of Health's current rate of £60 000 per QALY,24 this represents a ROI of 3.16 (£60 000−£13 000/£13 000). Fourth, this systematic review was partly prompted by recent government cuts to public health budgets in England. We therefore focused on public health interventions delivered in other high-income countries in order to maximise UK relevance. We can therefore now better estimate the likely opportunity costs of the proposed cuts in local and national public health budgets. The median ROI for all public health interventions was 14.3, and the median CBR was 8.3. An ROI of 14.3 implying a cash return of 1430% would sound too good to be true in the financial world. However, public health is different, because decision-making is governed by politics rather than markets. Our systematic review clearly demonstrates that there are big public health investment opportunities out there—they just need some political will to implement them. If we take the lower, conservative CBR figure of 8.3, this would suggest that the opportunity cost of the recent £200 million cuts to public health funding in England is likely to be eightfold higher, in the region of £1.6 billion. The UK government's ‘efficiency savings’ thus represent a false economy which will generate many billions of additional future costs to the ailing NHS and wider UK economy. The recent UK increases in (avoidable) teen pregnancies, sexually transmitted infections, homelessness and suicides are thus predictable and worrying. Do they represent harbingers of worse to come? Although this study draws on the experience of the UK public health system, there are implications for public health systems outside of the UK, which may be guided towards areas of potential underinvestment, and avoid harmful cuts in public health budgets.

Previous reviews

Ours may be the first comprehensive systematic review of ROI and CBR to include the broad spectrum of public health interventions. Furthermore, it extends and strengthens earlier, narrower reviews which consistently highlighted the cost-effectiveness of selected public health interventions. These included the Australian Assessing Cost Effectiveness (ACE) Prevention Study25 and the Health England Leading Priorities (HELP) Tool, which ranked several public health interventions against a set of criteria.26 NICE appraises and recommends public health programmes and interventions in England. In 2012, they reviewed 200 cost-effectiveness estimates used in their guidance. Many interventions (particularly around smoking cessation) produced a net cost-saving for the NHS, that is, the intervention was more effective and cheaper than the comparator.27 Most interventions were highly cost-effective with a very low cost per QALY: 85% were cost-effective at a threshold of £20 000 per QALY, and 89% at the higher £30 000 threshold, 5% exceeded £30 000 per QALY and only the final 5% were dominated (ie, more costly and less effective than the comparator).27

Health protection interventions

Eighteen studies reported ROI or CBR figures in relation to health protection interventions.7 8 10 11 28–40The median ROI for health protection interventions was very high at 34.2. The Australian single measles vaccination programme in the 1980s and 1990s reported the highest CBR, with a CBR of 167:1.10 The UK now uses the combined Measles, Mumps and Rubella vaccination that has an excellent ROI of 14:1.28 Seven studies assessed the prevention, notification, follow-up and treatment of infectious diseases such as hepatitis B and HIV. Overall, they demonstrated a consistently high ROI, reflecting the high disease burden of infectious diseases and the huge benefits of prevention.29 Calculating the ROI of influenza vaccination of healthy working adults is challenging, as it is highly sensitive to the efficacy of the seasonal vaccine. Thus, most such studies7 30 have reported a modest twofold ROI overall, but with extreme ROI values ranging from −21 to +174.30

Legislative interventions

One paper reported ROI in relation to legislative interventions, which offered substantial returns on investment, with a median ROI of 46.5. Furthermore, they are relatively low cost and target behaviour at a national level. Introducing a sugar sweetened beverage tax could save $55 for every single dollar invested15 in the USA.

Health promotion interventions

The 15 studies analysing health promotion interventions reported an overall twofold ROI with a more impressive median CBR of 14.4.10 13 14 22 41–51 Interventions aimed at reducing rates of falls are able to show one of the swiftest returns on investment of any of the public health interventions identified within this study, with a CBR of 20.6 returned within 18 months.41 Falls prevention interventions by their nature are relatively low cost (structured exercise programmes for those at risk of falls), and yet their potential impact on demand management for hospital services is clearly demonstrated. Shifting investment from secondary care for the treatment of falls to primary prevention would show significant and swift returns on investment. Tobacco control interventions10 42 43 overall reported a twofold ROIs, which increased when targeted at high-risk clients such as pregnant women.42 Such contrasting results perhaps highlight the complexity of public health interventions.

Healthcare public health interventions

Six studies17 18 52–55 reported healthcare public health results, offering a substantial median ROI of 5.14. The majority focused on disease management or medication adherence for high-risk patients, such as home blood pressure monitoring for hypertension diagnosis and treatment.18

Wider determinants interventions

Twelve studies reported results for wider determinants interventions.9 10 12 19–21 56–61 Public health interventions addressing wider determinants also averaged a fivefold ROI. Several studies assessed effectiveness of early years interventions, particularly those targeted at juvenile offenders, or those deemed to be at risk of future offending. Although much of this literature is from the USA20 21 56 57 emerging UK evidence demonstrates similar returns to society and the wider economy.58 The benefits of early years interventions thus extend far beyond health, with participants reporting improvements in literacy, job prospects and earnings (hence savings to the criminal justice system, increased taxation of higher earnings, etc). This also highlights the ‘cross-sector flow problem’: cost-effective public health programmes may not be commissioned if decision-makers are only looking through a narrow health lens.

Strengths

We describe a carefully conducted systematic review. Although the precision of application of ROI calculations varies widely, even the most rudimentary analyses consistently suggest that most public health interventions are substantially cost-saving.

Limitations

Several limitations should be considered. First, the difficulty of defining what constitutes a ‘public health intervention’, particularly those focused on wider determinants. We purposefully cast the net wide to achieve a broad systematic review. Further analysis of particular topic areas might now be beneficial. Second, publication bias appears likely, and even some published studies may have been missed. Such studies are inevitably scattered across a wide field of journals and some economic studies may only be available via organisational websites. However, we did search the grey literature and we did identify almost 3000 total studies—a reassuringly high number. Third, we did not conduct a formal meta-analysis because of the very inconsistent manner in which ROI was calculated, with differing cost perspectives, time horizons and discount rates. Discount rates ranged from 0% to 10%. A high discount rate disadvantages public health interventions that have a long payback time.62 Conversely, a 1 year time horizon may offer too short a time frame. Fourth, the generalisability of the interventions conducted from one country to the next will vary. Participants in US studies may poorly reflect UK demographics and vice versa. Furthermore, some studies focused on vaccination practices that are no longer employed in a number of countries (eg, single measles and haemophilus influenzae type b vaccinations). Similarly, the majority of workplace health promotion initiatives come from the USA, where employers who pay for employees' healthcare will have an additional financial incentive to promote the health of their workforce. Fifth, the quality of the economic evaluations varied considerably. Practice has clearly improved substantially since the 1970s, with recent evaluations employing more sophisticated modelling techniques. Designing such studies can be challenging as public health interventions are often complex and multifactorial, and it can be difficult to isolate an effect size even within a randomised controlled trial. Some of the published literature may therefore systematically overestimate or underestimate the ROI of interventions, and hence the need for more research.

Unanswered questions and future research

There is a clear need for further high-quality economic evaluations of public health interventions, which include a range of discount rates and robust sensitivity analyses.

Implications for clinicians and policymakers

Overall, the results of our systematic review clearly demonstrate that public health interventions are cost-saving, both to health services as well as the wider economy. Furthermore, some are very rapid: falls prevention interventions reported substantial returns within 6–12 months.41 One might reasonably expect equally rapid returns for preventive interventions such as immunisation, healthcare, smoking cessation and nutrition.63 Although attempting to quantify returns within a short timescale can be challenging, even larger returns on investment were seen over a 10–20 years time horizon.10 15 17 32 58 This has significant implications for policymakers, who often work to a much shorter time horizon (typically 3–5 years). We suggest that Public Health England, NICE and other advisory bodies therefore need to routinely emphasise that public health interventions can offer surprisingly rapid returns, which may increase further over the longer term.

Conclusions

This systematic review suggests that local public health interventions are cost-saving, and offer substantial returns on investment, nationwide programmes even more so. The cuts to public health budgets therefore represent a false economy. They are likely to generate billions of pounds of additional costs to the health services and wider economy. It is well known that it is financially preferable for healthcare systems to aim to prevent ill health rather than to subsequently treat it. A number of studies have calculated the return on investment for individual prevention interventions; however, no systematic review has spanned the breadth of public health. This systematic review demonstrates a median return on investment of public health interventions of ∼14:1. Thus, for every £1 invested in public health, £14 will subsequently be returned to the wider health and social care economy. Furthermore, this review categorises the return on investment according to the public health specialty and local versus national levels of intervention. It suggests that cuts to public health services are short sighted and represent a false economy, with substantial opportunity costs.
  47 in total

1.  Impact of universal Haemophilus influenzae type b vaccination starting at 2 months of age in the United States: an economic analysis.

Authors:  Fangjun Zhou; Kristine M Bisgard; Hussain R Yusuf; Robert R Deuson; Sue K Bath; Trudy V Murphy
Journal:  Pediatrics       Date:  2002-10       Impact factor: 7.124

2.  Cost-benefit analysis of multisystemic therapy with serious and violent juvenile offenders.

Authors:  Stephanie J Klietz; Charles M Borduin; Cindy M Schaeffer
Journal:  J Fam Psychol       Date:  2010-10

3.  What can a pilot congestive heart failure disease management program tell us about likely return on investment?: A case study from a program offered to federal employees.

Authors:  Catherine J vanVonno; Ronald J Ozminkowski; Mark W Smith; Eileen G Thomas; Doniece Kelley; Ron Goetzel; Gregory D Berg; Susheel K Jain; David R Walker
Journal:  Dis Manag       Date:  2005-12

Review 4.  Cost-effectiveness of HIV/AIDS interventions in Africa: a systematic review of the evidence.

Authors:  Andrew Creese; Katherine Floyd; Anita Alban; Lorna Guinness
Journal:  Lancet       Date:  2002-05-11       Impact factor: 79.321

5.  Benefits, risks and costs of immunization for measles, mumps and rubella.

Authors:  C C White; J P Koplan; W A Orenstein
Journal:  Am J Public Health       Date:  1985-07       Impact factor: 9.308

6.  Improving the cost-effectiveness of a healthcare system for depressive disorders by implementing telemedicine: a health economic modeling study.

Authors:  Joran Lokkerbol; Dirk Adema; Pim Cuijpers; Charles F Reynolds; Richard Schulz; Rifka Weehuizen; Filip Smit
Journal:  Am J Geriatr Psychiatry       Date:  2013-06-04       Impact factor: 4.105

7.  Syringe exchange in the United States: a national level economic evaluation of hypothetical increases in investment.

Authors:  Trang Quynh Nguyen; Brian W Weir; Don C Des Jarlais; Steven D Pinkerton; David R Holtgrave
Journal:  AIDS Behav       Date:  2014-11

8.  Methods for the estimation of the National Institute for Health and Care Excellence cost-effectiveness threshold.

Authors:  Karl Claxton; Steve Martin; Marta Soares; Nigel Rice; Eldon Spackman; Sebastian Hinde; Nancy Devlin; Peter C Smith; Mark Sculpher
Journal:  Health Technol Assess       Date:  2015-02       Impact factor: 4.014

9.  Costs and longer-term savings of parenting programmes for the prevention of persistent conduct disorder: a modelling study.

Authors:  Eva-Maria Bonin; Madeleine Stevens; Jennifer Beecham; Sarah Byford; Michael Parsonage
Journal:  BMC Public Health       Date:  2011-10-14       Impact factor: 3.295

10.  Childhood lead poisoning: conservative estimates of the social and economic benefits of lead hazard control.

Authors:  Elise Gould
Journal:  Environ Health Perspect       Date:  2009-03-31       Impact factor: 9.031

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  66 in total

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Authors:  Jason L Cabaj; Richard Musto; William A Ghali
Journal:  Can J Public Health       Date:  2019-04-12

Review 2.  Reviving a national prevention agenda is key to sustainability of health care in Canada.

Authors:  Robert Strang; Perry Kendall; Andre Corriveau
Journal:  CMAJ       Date:  2017-10-10       Impact factor: 8.262

3.  Formation of a National Lifestyle Medicine Network to Benefit Patients and Lifestyle Medicine Providers.

Authors:  David Donohue; Wayne Dysinger; Susan Benigas
Journal:  Am J Lifestyle Med       Date:  2019-09-11

4.  Supporting Adolescents to Adhere (SATA): Lessons learned from an intervention to achieve medication adherence targets among youth living with HIV in Uganda.

Authors:  Sarah MacCarthy; Alexandra Mendoza-Graf; Haijing Huang; Barbara Mukasa; Sebastian Linnemayr
Journal:  Child Youth Serv Rev       Date:  2019-04-06

5.  São Paulo call to action for the prevention and control of high blood pressure: 2020.

Authors:  Norm R C Campbell; Aletta E Schutte; Cherian V Varghese; Pedro Ordunez; Xin-Hua Zhang; Taskeen Khan; James E Sharman; Paul K Whelton; Gianfranco Parati; Michael A Weber; Marcelo Orías; Marc G Jaffe; Andrew E Moran; Frida Liane Plavnik; Venkata S Ram; Michael Brainin; Mayowa O Owolabi; Augstin J Ramirez; Eduardo Barbosa; Luiz Aparecido Bortolotto; Daniel T Lackland
Journal:  J Clin Hypertens (Greenwich)       Date:  2019-11-25       Impact factor: 3.738

6.  Estimating Population Benefits of Prevention Approaches Using a Risk Tool: High Resource Users in Ontario, Canada.

Authors:  Meghan O'Neill; Kathy Kornas; Walter P Wodchis; Laura C Rosella
Journal:  Healthc Policy       Date:  2021-02

Review 7.  How Do We Incorporate Polygenic Risk Scores in Cardiovascular Disease Risk Assessment and Management?

Authors:  Trevor D Hadley; Ali M Agha; Christie M Ballantyne
Journal:  Curr Atheroscler Rep       Date:  2021-04-01       Impact factor: 5.113

8.  Prevalence of Use of Preventive Services in Poland: Result from a Population-Based Nationwide Study.

Authors:  Siddarth Agrawal; Justyna Gołębiowska; Sebastian Makuch; Grzegorz Mazur
Journal:  J Clin Med       Date:  2021-05-12       Impact factor: 4.241

9.  Media representations of opposition to the 'junk food advertising ban' on the Transport for London (TfL) network: A thematic content analysis of UK news and trade press.

Authors:  Claire Thompson; Christelle Clary; Vanessa Er; Jean Adams; Emma Boyland; Thomas Burgoine; Laura Cornelsen; Frank de Vocht; Matt Egan; Amelia A Lake; Karen Lock; Oliver Mytton; Mark Petticrew; Martin White; Amy Yau; Steven Cummins
Journal:  SSM Popul Health       Date:  2021-05-27

Review 10.  'What You See is All There is': The Importance of Heuristics in Cost-Benefit Analysis (CBA) and Social Return on Investment (SROI) in the Evaluation of Public Health Interventions.

Authors:  Rhiannon Tudor Edwards; Catherine Louise Lawrence
Journal:  Appl Health Econ Health Policy       Date:  2021-05-31       Impact factor: 2.561

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