Literature DB >> 28356054

Role of Chirality in Drugs: An Overview.

Hourieh Alkadi1,2, Rajwa Jbeily1.   

Abstract

Stereochemistry has occupied a great role in the manufacture and development of pharmaceuticals. Chiral properties play an important role in the determination of pharmacological actions of the drug. In recent years, there is a considerable interest in chiral separation to isolate and examine both enantiomers. This article provides an overview about the stereochemistry and its role in drugs, and also, offers approved isolation methods for enantiomeric pairs. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

Keywords:  Chirality; chiral drug; chiral separation; enantiomer; pharmacology; stereoisomer.

Mesh：

Substances：

Year:  2018        PMID： 28356054     DOI： 10.2174/1871526517666170329123845

Source DB:  PubMed          Journal:  Infect Disord Drug Targets        ISSN： 1871-5265


  5 in total

1.  Determination and Comparison of the Solubility, Oil-Water Partition Coefficient, Intestinal Absorption, and Biliary Excretion of Carvedilol Enantiomers.

Authors:  Qi Zhang; Xin Wang; Hongjiao Xue; Baolin Huang; Zimin Lin; Zheng Cai
Journal:  AAPS PharmSciTech       Date:  2021-01-10       Impact factor: 3.246

2.  Enantiomeric Resolution and Absolute Configuration of a Chiral δ-Lactam, Useful Intermediate for the Synthesis of Bioactive Compounds.

Authors:  Roberta Listro; Giacomo Rossino; Serena Della Volpe; Rita Stabile; Massimo Boiocchi; Lorenzo Malavasi; Daniela Rossi; Simona Collina
Journal:  Molecules       Date:  2020-12-19       Impact factor: 4.411

3.  Analytical Separation of Closantel Enantiomers by HPLC.

Authors:  Basma Saleh; Tongyan Ding; Yuwei Wang; Xiantong Zheng; Rong Liu; Limin He
Journal:  Molecules       Date:  2021-11-30       Impact factor: 4.411

4.  Comparative pharmacokinetics and tissue distribution of primaquine enantiomers in mice.

Authors:  Pius S Fasinu; Narayan D Chaurasiya; N P Dhammika Nanayakkara; Yan-Hong Wang; H M T Bandara Herath; Bharathi Avula; James D McChesney; David Jollow; Larry A Walker; Babu L Tekwani
Journal:  Malar J       Date:  2022-02-05       Impact factor: 2.979

5.  Chiral mono- and dicarbamates derived from ethyl (S)-lactate: convenient chiral solvating agents for the direct and efficient enantiodiscrimination of amino acid derivatives by 1H NMR spectroscopy.

Authors:  Federica Balzano; Gloria Uccello-Barretta
Journal:  RSC Adv       Date:  2020-01-29       Impact factor: 4.036
  5 in total

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