Literature DB >> 2835349

Coumarins as inhibitors of bacterial DNA gyrase.

I W Althaus1, L Dolak, F Reusser.   

Abstract

Chlorobiocic acid and 3-(carbobenzoxyamino)-4,7-dihydroxy-8-methylcoumarin were identified as two new inhibitors of Micrococcus luteus DNA gyrase. Both compounds possess weak antibacterial activity against whole M. luteus cells which indicates that they probably lack efficient transport functions to penetrate the cell envelope.

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Year:  1988        PMID： 2835349     DOI： 10.7164/antibiotics.41.373

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  4 in total

1.  Mass spectrometric characterization of a three-enzyme tandem reaction for assembly and modification of the novobiocin skeleton.

Authors:  Na Pi; Caren L Freel Meyers; Michelle Pacholec; Christopher T Walsh; Julie A Leary
Journal:  Proc Natl Acad Sci U S A       Date:  2004-06-24       Impact factor: 11.205

2.  The amphiphilic properties of novenamines determine their activity as inhibitors of HIV-1 RNase H.

Authors:  I W Althaus; K M Franks; K B Langley; F J Kézdy; T Peterson; S E Buxser; D E Decker; L A Dolak; R G Ulrich; F Reusser
Journal:  Experientia       Date:  1996-04-15

3.  Identification of the coumermycin A(1) biosynthetic gene cluster of Streptomyces rishiriensis DSM 40489.

Authors:  Z X Wang; S M Li; L Heide
Journal:  Antimicrob Agents Chemother       Date:  2000-11       Impact factor: 5.191

4.  The nature of inhibition of DNA gyrase by the coumarins and the cyclothialidines revealed by X-ray crystallography.

Authors:  R J Lewis; O M Singh; C V Smith; T Skarzynski; A Maxwell; A J Wonacott; D B Wigley
Journal:  EMBO J       Date:  1996-03-15       Impact factor: 11.598
  4 in total

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