Literature DB >> 2835321

Influence of cationic superoxide generation enhancing protein (SGEP) on phagocytic and intracellular bactericidal activity of human polymorphonuclear cells.

W Pruzanski1, S Saito, M Alam, N S Ranadive.   

Abstract

Cationic fraction III from the lysosomes of normal human peripheral blood polymorphonuclear cells (PMNs) was found to contain superoxide generation enhancing protein (SGEP). Herein, we report on the influence of partially purified SGEP obtained from fraction III (subfractions III-5 and III-6), on various phagocytic functions of human PMNs. SGEP markedly enhanced intracellular bactericidal activity of human peripheral PMNs. The enhancement was time and dose dependent. It also reduced adhesiveness of the PMNs. SGEP did not influence chemotaxis, phagocytosis or phagocytic index. These findings are compatible with our original observation regarding superoxide generation enhancement properties of SGEP.

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Year:  1988        PMID： 2835321     DOI： 10.1007/BF00915895

Source DB:  PubMed          Journal:  Inflammation        ISSN： 0360-3997            Impact factor:   4.092


  19 in total

1.  Chemotaxis under agarose: a new and simple method for measuring chemotaxis and spontaneous migration of human polymorphonuclear leukocytes and monocytes.

Authors:  R D Nelson; P G Quie; R L Simmons
Journal:  J Immunol       Date:  1975-12       Impact factor: 5.422

2.  The role of superoxide anion generation in phagocytic bactericidal activity. Studies with normal and chronic granulomatous disease leukocytes.

Authors:  R B Johnston; B B Keele; H P Misra; J E Lehmeyer; L S Webb; R L Baehner; K V RaJagopalan
Journal:  J Clin Invest       Date:  1975-06       Impact factor: 14.808

Review 3.  Stimulated neutrophil locomotion: chemokinesis and chemotaxis.

Authors:  E L Becker
Journal:  Arch Pathol Lab Med       Date:  1977-10       Impact factor: 5.534

4.  The effect of anti-inflammatory agents and inflammation on granulocyte adherence. Evidence for regulation by plasma factors.

Authors:  R R MacGregor
Journal:  Am J Med       Date:  1976-11       Impact factor: 4.965

5.  Cationic proteins of human granulocytes. II. Separation of the cationic proteins of the granules of leukemic myeloid cells.

Authors:  I Olsson; P Venge
Journal:  Blood       Date:  1974-08       Impact factor: 22.113

6.  Influence of neutrophil cationic proteins on generation of superoxide by human polymorphonuclear cells during phagocytosis.

Authors:  M Alam; N S Ranadive; W Pruzanski
Journal:  Inflammation       Date:  1987-06       Impact factor: 4.092

7.  The influence of lysostaphin on phagocytosis, intracellular bactericidal activity, and chemotaxis of human polymorphonuclear cells.

Authors:  W Pruzanski; S Saito; D W Nitzan
Journal:  J Lab Clin Med       Date:  1983-08

8.  Modulation of locomotor activity of polymorphonuclear cells by cationic substances and cationic lysosomal fractions from human neutrophils.

Authors:  D W Nitzan; W Pruzanski; S Saito; N Ranadive
Journal:  Inflammation       Date:  1985-12       Impact factor: 4.092

9.  Defensins. Natural peptide antibiotics of human neutrophils.

Authors:  T Ganz; M E Selsted; D Szklarek; S S Harwig; K Daher; D F Bainton; R I Lehrer
Journal:  J Clin Invest       Date:  1985-10       Impact factor: 14.808

10.  Modulation of phagocytosis and intracellular bactericidal activity of polymorphonuclear and mononuclear cells by cationic proteins from human granulocytes: alternative pathway of phagocytic enhancement.

Authors:  W Pruzanski; N S Ranadive; S Saito
Journal:  Inflammation       Date:  1984-12       Impact factor: 4.092
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  2 in total

1.  Comparison of group I and II soluble phospholipases A2 activities on phagocytic functions of human polymorphonuclear and mononuclear phagocytes.

Authors:  W Pruzanski; S Saito; E Stefanski; P Vadas
Journal:  Inflammation       Date:  1991-04       Impact factor: 4.092

2.  Modulation of functional activity of human polymorphonuclear and mononuclear phagocytes by intravenous gamma globulin.

Authors:  W Pruzanski; S Saito
Journal:  Inflammation       Date:  1989-06       Impact factor: 4.092
  2 in total

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