Literature DB >> 28352131

Drug therapy: Exploiting synthetic lethality to improve cancer therapy.

Diede Brunen1, René Bernards1.   

Abstract

Entities:  

Mesh：

Substances：

Year:  2017        PMID： 28352131     DOI： 10.1038/nrclinonc.2017.46

Source DB:  PubMed          Journal:  Nat Rev Clin Oncol        ISSN： 1759-4774            Impact factor:   66.675


× No keyword cloud information.
  9 in total

1.  Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR.

Authors:  Anirudh Prahallad; Chong Sun; Sidong Huang; Federica Di Nicolantonio; Ramon Salazar; Davide Zecchin; Roderick L Beijersbergen; Alberto Bardelli; René Bernards
Journal:  Nature       Date:  2012-01-26       Impact factor: 49.962

Review 2.  Opportunities and challenges provided by crosstalk between signalling pathways in cancer.

Authors:  A Prahallad; R Bernards
Journal:  Oncogene       Date:  2015-05-18       Impact factor: 9.867

3.  Long-Term Outcomes of Imatinib Treatment for Chronic Myeloid Leukemia.

Authors:  Andreas Hochhaus; Richard A Larson; François Guilhot; Jerald P Radich; Susan Branford; Timothy P Hughes; Michele Baccarani; Michael W Deininger; Francisco Cervantes; Satoko Fujihara; Christine-Elke Ortmann; Hans D Menssen; Hagop Kantarjian; Stephen G O'Brien; Brian J Druker
Journal:  N Engl J Med       Date:  2017-03-09       Impact factor: 91.245

4.  Gene Essentiality Profiling Reveals Gene Networks and Synthetic Lethal Interactions with Oncogenic Ras.

Authors:  Tim Wang; Haiyan Yu; Nicholas W Hughes; Bingxu Liu; Arek Kendirli; Klara Klein; Walter W Chen; Eric S Lander; David M Sabatini
Journal:  Cell       Date:  2017-02-02       Impact factor: 41.582

5.  Synthetic essentiality of chromatin remodelling factor CHD1 in PTEN-deficient cancer.

Authors:  Di Zhao; Xin Lu; Guocan Wang; Zhengdao Lan; Wenting Liao; Jun Li; Xin Liang; Jasper Robin Chen; Sagar Shah; Xiaoying Shang; Ming Tang; Pingna Deng; Prasenjit Dey; Deepavali Chakravarti; Peiwen Chen; Denise J Spring; Nora M Navone; Patricia Troncoso; Jianhua Zhang; Y Alan Wang; Ronald A DePinho
Journal:  Nature       Date:  2017-02-06       Impact factor: 49.962

6.  Cancer. Addiction to oncogenes--the Achilles heal of cancer.

Authors:  I Bernard Weinstein
Journal:  Science       Date:  2002-07-05       Impact factor: 47.728

7.  Non-oncogene addiction and the stress phenotype of cancer cells.

Authors:  Nicole L Solimini; Ji Luo; Stephen J Elledge
Journal:  Cell       Date:  2007-09-21       Impact factor: 41.582

8.  Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase.

Authors:  Helen E Bryant; Niklas Schultz; Huw D Thomas; Kayan M Parker; Dan Flower; Elena Lopez; Suzanne Kyle; Mark Meuth; Nicola J Curtin; Thomas Helleday
Journal:  Nature       Date:  2005-04-14       Impact factor: 69.504

9.  Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy.

Authors:  Hannah Farmer; Nuala McCabe; Christopher J Lord; Andrew N J Tutt; Damian A Johnson; Tobias B Richardson; Manuela Santarosa; Krystyna J Dillon; Ian Hickson; Charlotte Knights; Niall M B Martin; Stephen P Jackson; Graeme C M Smith; Alan Ashworth
Journal:  Nature       Date:  2005-04-14       Impact factor: 69.504
  9 in total
  12 in total

Review 1.  Exploiting Synthetic Lethality and Network Biology to Overcome EGFR Inhibitor Resistance in Lung Cancer.

Authors:  Simon Vyse; Annie Howitt; Paul H Huang
Journal:  J Mol Biol       Date:  2017-05-03       Impact factor: 5.469

2.  Somatic mutation of the cohesin complex subunit confers therapeutic vulnerabilities in cancer.

Authors:  Yunhua Liu; Hanchen Xu; Kevin Van der Jeught; Yujing Li; Sheng Liu; Lu Zhang; Yuanzhang Fang; Xinna Zhang; Milan Radovich; Bryan P Schneider; Xiaoming He; Cheng Huang; Chi Zhang; Jun Wan; Guang Ji; Xiongbin Lu
Journal:  J Clin Invest       Date:  2018-06-04       Impact factor: 14.808

3.  APE1/Ref-1 knockdown in pancreatic ductal adenocarcinoma - characterizing gene expression changes and identifying novel pathways using single-cell RNA sequencing.

Authors:  Fenil Shah; Emery Goossens; Nadia M Atallah; Michelle Grimard; Mark R Kelley; Melissa L Fishel
Journal:  Mol Oncol       Date:  2017-10-19       Impact factor: 6.603

4.  The Effect of VPA on Increasing Radiosensitivity in Osteosarcoma Cells and Primary-Culture Cells from Chemical Carcinogen-Induced Breast Cancer in Rats.

Authors:  Guochao Liu; Hui Wang; Fengmei Zhang; Youjia Tian; Zhujun Tian; Zuchao Cai; David Lim; Zhihui Feng
Journal:  Int J Mol Sci       Date:  2017-05-10       Impact factor: 5.923

5.  Blocking HIF signaling via novel inhibitors of CA9 and APE1/Ref-1 dramatically affects pancreatic cancer cell survival.

Authors:  Derek P Logsdon; Fenil Shah; Fabrizio Carta; Claudiu T Supuran; Malgorzata Kamocka; Max H Jacobsen; George E Sandusky; Mark R Kelley; Melissa L Fishel
Journal:  Sci Rep       Date:  2018-09-13       Impact factor: 4.379

Review 6.  Importance of genetic screens in precision oncology.

Authors:  Antonio Mulero-Sánchez; Ziva Pogacar; Loredana Vecchione
Journal:  ESMO Open       Date:  2019-05-24

7.  vulcanSpot: a tool to prioritize therapeutic vulnerabilities in cancer.

Authors:  Javier Perales-Patón; Tomás Di Domenico; Coral Fustero-Torre; Elena Piñeiro-Yáñez; Carlos Carretero-Puche; Héctor Tejero; Alfonso Valencia; Gonzalo Gómez-López; Fátima Al-Shahrour
Journal:  Bioinformatics       Date:  2019-11-01       Impact factor: 6.937

8.  WDHD1 is essential for the survival of PTEN-inactive triple-negative breast cancer.

Authors:  Ayse Ertay; Huiquan Liu; Dian Liu; Ping Peng; Charlotte Hill; Hua Xiong; David Hancock; Xianglin Yuan; Marcin R Przewloka; Mark Coldwell; Michael Howell; Paul Skipp; Rob M Ewing; Julian Downward; Yihua Wang
Journal:  Cell Death Dis       Date:  2020-11-21       Impact factor: 8.469

9.  Synthetic lethal combination targeting BET uncovered intrinsic susceptibility of TNBC to ferroptosis.

Authors:  Nandini Verma; Yaron Vinik; Ashish Saroha; Nishanth Ulhas Nair; Eytan Ruppin; Gordon Mills; Thomas Karn; Vinay Dubey; Lohit Khera; Harsha Raj; Flavio Maina; Sima Lev
Journal:  Sci Adv       Date:  2020-08-21       Impact factor: 14.136

10.  Combined inhibition of Ref-1 and STAT3 leads to synergistic tumour inhibition in multiple cancers using 3D and in vivo tumour co-culture models.

Authors:  Rachel A Caston; Fenil Shah; Colton L Starcher; Randall Wireman; Olivia Babb; Michelle Grimard; Jack McGeown; Lee Armstrong; Yan Tong; Roberto Pili; Joseph Rupert; Teresa A Zimmers; Adily N Elmi; Karen E Pollok; Edward A Motea; Mark R Kelley; Melissa L Fishel
Journal:  J Cell Mol Med       Date:  2020-12-03       Impact factor: 5.295
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.