Literature DB >> 2835038

Mode of action of pentavalent antimonials: specific inhibition of type I DNA topoisomerase of Leishmania donovani.

A K Chakraborty1, H K Majumder.   

Abstract

Sodium stibogluconate and Ureastibamine, two potent antileishmanial drugs specifically inhibit the relaxation of supercoiled plasmid pBR322 catalyzed by DNA topoisomerase I of Leishmania donovani. Dose dependent inhibition suggests that the drugs interact with the enzyme rather than the DNA. The inhibition reported here concerning a type I DNA topoisomerase demonstrates at least one possible mode of action of these antileishmanial drugs.

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Year:  1988        PMID： 2835038     DOI： 10.1016/s0006-291x(88)80081-0

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  20 in total

1.  Luteolin, an emerging anti-cancer flavonoid, poisons eukaryotic DNA topoisomerase I.

Authors:  Arnab Roy Chowdhury; Shalini Sharma; Suparna Mandal; Anindya Goswami; Sibabrata Mukhopadhyay; Hemanta K Majumder
Journal:  Biochem J       Date:  2002-09-01       Impact factor: 3.857

2.  Use of in vitro method to assess different brands of anti-leishmanial drugs.

Authors:  S K Arora; R Sinha; S Sehgal
Journal:  Med Microbiol Immunol       Date:  1991       Impact factor: 3.402

3.  Suppression of both antimony-susceptible and antimony-resistant Leishmania donovani by a bis(benzyl)polyamine analog.

Authors:  R J Baumann; W L Hanson; P P McCann; A Sjoerdsma; A J Bitonti
Journal:  Antimicrob Agents Chemother       Date:  1990-05       Impact factor: 5.191

4.  The efficacy of enrofloxacin, alone or combined with metronidazole, in the therapy of canine leishmaniasis.

Authors:  Paolo Bianciardi; Antonio Fasanella; Valentina Foglia Manzillo; Teresa Trotta; Annalisa Pagano; Simona Sorino; Luigi Gradoni; Gaetano Oliva
Journal:  Parasitol Res       Date:  2004-07-23       Impact factor: 2.289

5.  Sensitivity of Leishmania viannia panamensis to pentavalent antimony is correlated with the formation of cleavable DNA-protein complexes.

Authors:  A Lucumi; S Robledo; V Gama; N G Saravia
Journal:  Antimicrob Agents Chemother       Date:  1998-08       Impact factor: 5.191

6.  Inhibitory effects of cholesterol derivatives on DNA polymerase and topoisomerase activities, and human cancer cell growth.

Authors:  Chisato Ishimaru; Yuko Yonezawa; Isoko Kuriyama; Masayuki Nishida; Hiromi Yoshida; Yoshiyuki Mizushina
Journal:  Lipids       Date:  2008-01-24       Impact factor: 1.880

7.  Increased levels of thiols protect antimony unresponsive Leishmania donovani field isolates against reactive oxygen species generated by trivalent antimony.

Authors:  G Mandal; S Wyllie; N Singh; S Sundar; A H Fairlamb; M Chatterjee
Journal:  Parasitology       Date:  2007-07-05       Impact factor: 3.234

Review 8.  Visceral leishmaniasis treatment: What do we have, what do we need and how to deliver it?

Authors:  Lucio H Freitas-Junior; Eric Chatelain; Helena Andrade Kim; Jair L Siqueira-Neto
Journal:  Int J Parasitol Drugs Drug Resist       Date:  2012-01-28       Impact factor: 4.077

9.  9-Anilinoacridines as potential antileishmanial agents.

Authors:  J Mauël; W Denny; S Gamage; A Ransijn; S Wojcik; D Figgitt; R Ralph
Journal:  Antimicrob Agents Chemother       Date:  1993-05       Impact factor: 5.191

10.  The relationship between the molecular structure of natural acetogenins and their inhibitory activities which affect DNA polymerase, DNA topoisomerase and human cancer cell growth.

Authors:  Yuki Matsui; Toshifumi Takeuchi; Yuko Kumamoto-Yonezawa; Masaharu Takemura; Fumio Sugawara; Hiromi Yoshida; Yoshiyuki Mizushina
Journal:  Exp Ther Med       Date:  2010-01-01       Impact factor: 2.447
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