Literature DB >> 2834999

In vitro activity of LY146032 alone and in combination with other antibiotics against gram-positive bacteria.

E Debbia1, A Pesce, G C Schito.   

Abstract

The antibacterial activity of LY146032 alone and in combination with other drugs was assayed against gram-positive isolates. Synergism was found when LY146032 was combined with netilmicin, amikacin, imipenem, and fosfomycin by both checkerboard and time-kill tests. Indifference predominated when LY146032 was combined with teicoplanin, vancomycin, and rifampin. Under no circumstances and with no combinations was an antagonistic effect detected.

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Year:  1988        PMID： 2834999      PMCID： PMC172154          DOI： 10.1128/AAC.32.2.279

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  10 in total

1.  Antimicrobial activity and spectrum of LY146032, a lipopeptide antibiotic, including susceptibility testing recommendations.

Authors:  R N Jones; A L Barry
Journal:  Antimicrob Agents Chemother       Date:  1987-04       Impact factor: 5.191

2.  In vitro activity of LY146032 against staphylococci, streptococci, and enterococci.

Authors:  R J Fass; V L Helsel
Journal:  Antimicrob Agents Chemother       Date:  1986-11       Impact factor: 5.191

3.  In vitro and in vivo activity of LY 146032, a new cyclic lipopeptide antibiotic.

Authors:  G M Eliopoulos; S Willey; E Reiszner; P G Spitzer; G Caputo; R C Moellering
Journal:  Antimicrob Agents Chemother       Date:  1986-10       Impact factor: 5.191

4.  In vitro activity of imipenem against enterococci and staphylococci and evidence for high rates of synergism with teicoplanin, fosfomycin, and rifampin.

Authors:  E Debbia; P E Varaldo; G C Schito
Journal:  Antimicrob Agents Chemother       Date:  1986-11       Impact factor: 5.191

Review 5.  Antibiotic synergism and antimicrobial combinations in clinical infections.

Authors:  G M Eliopoulos; R C Moellering
Journal:  Rev Infect Dis       Date:  1982 Mar-Apr

6.  Problems in determination of antibiotic synergism in vitro.

Authors:  C W Norden
Journal:  Rev Infect Dis       Date:  1982 Mar-Apr

7.  Defective killing of enterococci: a common property of antimicrobial agents acting on the cell wall.

Authors:  D J Krogstad; A R Pargwette
Journal:  Antimicrob Agents Chemother       Date:  1980-06       Impact factor: 5.191

8.  Lack of in vivo and in vitro bactericidal activity of N-formimidoyl thienamycin against enterococci.

Authors:  R Auckenthaler; W R Wilson; A J Wright; J A Washington; D T Durack; J E Geraci
Journal:  Antimicrob Agents Chemother       Date:  1982-09       Impact factor: 5.191

Review 9.  Combination antibiotic therapy of bacterial endocarditis.

Authors:  M A Sande; W M Scheld
Journal:  Ann Intern Med       Date:  1980-03       Impact factor: 25.391

10.  In vitro activity of teichomycin and vancomycin alone and in combination with rifampin.

Authors:  P E Varaldo; E Debbia; G C Schito
Journal:  Antimicrob Agents Chemother       Date:  1983-03       Impact factor: 5.191
  10 in total
  17 in total

1.  High-dose daptomycin plus fosfomycin is safe and effective in treating methicillin-susceptible and methicillin-resistant Staphylococcus aureus endocarditis.

Authors:  José M Miró; José M Entenza; Ana Del Río; Maria Velasco; Ximena Castañeda; Cristina Garcia de la Mària; Marlyse Giddey; Yolanda Armero; Juan M Pericàs; Carlos Cervera; Carlos A Mestres; Manuel Almela; Carlos Falces; Francesc Marco; Philippe Moreillon; Asuncion Moreno
Journal:  Antimicrob Agents Chemother       Date:  2012-05-29       Impact factor: 5.191

2.  Fosfomycin Enhances the Activity of Daptomycin against Vancomycin-Resistant Enterococci in an In Vitro Pharmacokinetic-Pharmacodynamic Model.

Authors:  Ashley D Hall Snyder; Brian J Werth; Poochit Nonejuie; John P McRoberts; Joe Pogliano; George Sakoulas; Juwon Yim; Nivedita Singh; Michael J Rybak
Journal:  Antimicrob Agents Chemother       Date:  2016-09-23       Impact factor: 5.191

3.  Altered growth, pigmentation, and antimicrobial susceptibility properties of Staphylococcus aureus due to loss of the major cold shock gene cspB.

Authors:  Brea D Duval; Anselmo Mathew; Sarah W Satola; William M Shafer
Journal:  Antimicrob Agents Chemother       Date:  2010-04-05       Impact factor: 5.191

4.  Daptomycin, fosfomycin, or both for treatment of methicillin-resistant Staphylococcus aureus osteomyelitis in an experimental rat model.

Authors:  W Poeppl; S Tobudic; T Lingscheid; R Plasenzotti; N Kozakowski; H Lagler; A Georgopoulos; H Burgmann
Journal:  Antimicrob Agents Chemother       Date:  2011-08-22       Impact factor: 5.191

5.  Dactimicin, a new aminoglycoside: in vitro activity, post-antibiotic effect and interaction with other antibiotics.

Authors:  P Paglia; G Molinari; A Pesce; E A Debbia
Journal:  Eur J Clin Microbiol Infect Dis       Date:  1989-07       Impact factor: 3.267

6.  Ex vivo study of serum bactericidal titers and killing rates of daptomycin (LY146032) combined or not combined with amikacin compared with those of vancomycin.

Authors:  P Van der Auwera
Journal:  Antimicrob Agents Chemother       Date:  1989-10       Impact factor: 5.191

7.  Bactericidal activities of peptide antibiotics against multidrug-resistant Enterococcus faecium.

Authors:  N Mobarakai; J M Quale; D Landman
Journal:  Antimicrob Agents Chemother       Date:  1994-02       Impact factor: 5.191

8.  Role of tolerance in treatment and prophylaxis of experimental Staphylococcus aureus endocarditis with vancomycin, teicoplanin, and daptomycin.

Authors:  G P Voorn; J Kuyvenhoven; W H Goessens; W C Schmal-Bauer; P H Broeders; J Thompson; M F Michel
Journal:  Antimicrob Agents Chemother       Date:  1994-03       Impact factor: 5.191

9.  Susceptibility of frequent urinary pathogens to fosfomycin trometamol and eight other antibiotics: results of an Italian multicenter survey.

Authors:  G C Schito; C Chezzi; G Nicoletti; M Moreddu; M C Arcangeletti; S Stefani; E Albini; G P Del Bono
Journal:  Infection       Date:  1992       Impact factor: 3.553

10.  The Combination of Daptomycin and Fosfomycin Has Synergistic, Potent, and Rapid Bactericidal Activity against Methicillin-Resistant Staphylococcus aureus in a Rabbit Model of Experimental Endocarditis.

Authors:  Cristina García-de-la-Mària; Oriol Gasch; Javier García-Gonzalez; Dolors Soy; Evelyn Shaw; Juan Ambrosioni; Manel Almela; Juan M Pericàs; Adrián Tellez; Carlos Falces; Marta Hernandez-Meneses; Elena Sandoval; Eduard Quintana; Barbara Vidal; Jose M Tolosana; David Fuster; Jaume Llopis; Miquel Pujol; Asuncion Moreno; Francesc Marco; Jose M Miró
Journal:  Antimicrob Agents Chemother       Date:  2018-05-25       Impact factor: 5.191
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