| Literature DB >> 2834763 |
A Weizman1, H Morgenstern, B Kaplan, Z Amiri, S Tyano, Y Ovadia, M Rehavi.
Abstract
Triphasic oral contraceptive (Logynon) induced a significant increase (36%) in the maximal binding capacity of platelet membranes for [3H]imipramine. The increase was achieved in the second Logynon cycle as compared to pretreatment and first Logynon cycle binding values. The pill contains a combination of ethinyl estradiol and levonorgestrel, and it is as yet unclear which of the two hormones is responsible for the up-regulatory effect. The increase in the density of platelet imipramine binding sites may reflect a similar alteration in brain. The increase in imipramine binding did not correlate with alteration in mood as assessed by Beck Depression Inventory scores.Entities:
Keywords: Asia; Biology; Contraception; Contraceptive Agents; Contraceptive Agents, Estrogen; Contraceptive Agents, Female; Contraceptive Agents, Progestin; Contraceptive Methods; Depression; Developed Countries; Developing Countries; Diseases; Endocrine System; Ethinyl Estradiol; Family Planning; Hormone Receptors; Hormones; Israel; Levonorgestrel; Mediterranean Countries; Membrane Proteins; Mental Disorders; Oral Contraceptives; Oral Contraceptives, Combined; Oral Contraceptives, Phasic; Physiology; Western Asia
Mesh：
Substances：
Year: 1988 PMID： 2834763 DOI： 10.1016/0165-1781(88)90031-5
Source DB: PubMed Journal: Psychiatry Res ISSN： 0165-1781 Impact factor: 3.222