Zhongzheng Niu1, Chuanbo Xie2, Xiaozhong Wen3, Fuying Tian1, Peng Ding1, Yanhui He1, Lijun Fan1, Shixin Yuan4, Deqin Jia5, Wei-Qing Chen1. 1. a Department of Biostatistics and Epidemiology, School of Public Health , Sun Yat-sen University , Guangzhou , PR China. 2. b Department of Cancer Prevention Research, State Key Laboratory of Oncology in South China , Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center , Guangzhou , PR China. 3. c Department of Pediatrics, Division of Behavioral Medicine, School of Medicine and Biomedical Sciences , State University of New York at Buffalo , Buffalo , NY , USA. 4. d Shenzhen Women and Children's Hospital , Shenzhen , PR China. 5. e Foshan Women and Children's Hospital , Foshan , PR China.
Abstract
OBJECTIVES: To explore the mediation effects of maternal serum interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) on the association between environmental tobacco smoke (ETS) exposure during pregnancy and low birth weight (LBW) at term. METHODS: ETS exposure, birth weight, blood sample and covariates were collected from 195 pregnant women delivered term LBW infants and 195 controls delivered normal birth weight infants in two Maternity and Child Hospitals in Guangdong, China. Maternal serum IL-1β and TNF-α were measured by flow cytometry. Logistic regression models and path analyses explored the mediation effects of maternal IL-1β and TNF-α on the association between ETS exposure and LBW. RESULTS: LBW was significantly associated with maternal ETS exposure (OR = 2.14 (95% CI =1.06-4.32)). TNF-α and IL-1β were significantly associated with both LBW (OR = 1.87 (1.41-2.47) and OR = 1.53 (1.14-2.05)) and ETS (β = 0.32 (0.04-0.60) and β = 0.27 (0.05-0.49)). Traditional mediation analyses indicated the separate mediation effect of TNF-α and IL-1β was 32.2% and 24.6%, respectively. Path analysis revealed the combined mediation effects of TNF-α and IL-1β as 29.4% in the pathway from ETS exposure to LBW. CONCLUSIONS: Maternal serum IL-1β and TNF-α may play a mediating role in the association between maternal ETS exposure during pregnancy and term LBW.
OBJECTIVES: To explore the mediation effects of maternal serum interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) on the association between environmental tobacco smoke (ETS) exposure during pregnancy and low birth weight (LBW) at term. METHODS: ETS exposure, birth weight, blood sample and covariates were collected from 195 pregnant women delivered term LBW infants and 195 controls delivered normal birth weight infants in two Maternity and Child Hospitals in Guangdong, China. Maternal serum IL-1β and TNF-α were measured by flow cytometry. Logistic regression models and path analyses explored the mediation effects of maternal IL-1β and TNF-α on the association between ETS exposure and LBW. RESULTS: LBW was significantly associated with maternal ETS exposure (OR = 2.14 (95% CI =1.06-4.32)). TNF-α and IL-1β were significantly associated with both LBW (OR = 1.87 (1.41-2.47) and OR = 1.53 (1.14-2.05)) and ETS (β = 0.32 (0.04-0.60) and β = 0.27 (0.05-0.49)). Traditional mediation analyses indicated the separate mediation effect of TNF-α and IL-1β was 32.2% and 24.6%, respectively. Path analysis revealed the combined mediation effects of TNF-α and IL-1β as 29.4% in the pathway from ETS exposure to LBW. CONCLUSIONS: Maternal serum IL-1β and TNF-α may play a mediating role in the association between maternal ETS exposure during pregnancy and term LBW.
Authors: Chloe Friedman; Dana Dabelea; Deborah S K Thomas; Jennifer L Peel; John L Adgate; Sheryl Magzamen; Sheena E Martenies; William B Allshouse; Anne P Starling Journal: Environ Res Date: 2021-04-20 Impact factor: 8.431