Lawrence T Dauer1, Elizabeth A Ainsbury2, Joseph Dynlacht3, David Hoel4, Barbara E K Klein5, Donald Mayer6, Christina R Prescott7, Raymond H Thornton1, Eliseo Vano8, Gayle E Woloschak9, Cynthia M Flannery10, Lee E Goldstein11, Nobuyuki Hamada12, Phung K Tran13, Michael P Grissom14, Eleanor A Blakely15. 1. a Radiology & Medical Physics , Memorial Sloan Kettering Cancer Center , New York , NY , USA. 2. b Centre for Radiation, Chemical and Environmental Hazards (CRCE) , Public Health England , Oxford , UK. 3. c Radiation Oncology , Indiana University School of Medicine , Indianapolis , IN , USA. 4. d Public Health Services , Medical University of South Carolina , Charleston , SC , USA. 5. e Ophthalmology & Visual Sciences , University of Wisconsin-Madison , Madison , WI , USA. 6. f Special Projects , Indian Point Energy Center , Buchanan , NY , USA. 7. g Wilmer Eye Institute , Johns Hopkins Medicine , Bel Air , MD , USA. 8. h Radiology , Complutense University , Madrid , Spain. 9. i Radiation Oncology , Northwestern University , Chicago , IL , USA. 10. j Office of Nuclear Material Safety and Safeguards , U.S. Nuclear Regulatory Commission , Rockville , MD , USA. 11. k Pathology & Laboratory Medicine , Boston University , Boston , MA , USA. 12. l Nuclear Technology Research Center , Central Research Institute of Electric Power Industry , Tokyo , Japan. 13. m Radiation Safety Program , Electric Power Research Institute , Palo Alto , CA , USA. 14. n National Council on Radiation Protection and Measurements , Bethesda , MD , USA. 15. o Life Sciences Division , Lawrence Berkeley National Laboratory , Berkeley , CA , USA.
Abstract
PURPOSE: This review summarizes the conclusions and recommendations of the new National Council on Radiation Protection and Measurements (NCRP) Commentary No. 26 guidance on radiation dose limits for the lens of the eye. The NCRP addressed radiation protection principles in respect to the lens of the eye, discussed the current understanding of eye biology and lens effects, reviewed and evaluated epidemiology, and assessed exposed populations with the potential for significant radiation exposures to the lens while suggesting monitoring and protection practices. CONCLUSIONS: Radiation-induced damage to the lens of the eye can include the loss of clarity resulting in opacification or clouding several years after exposure. The impact is highly dependent on the type of radiation, how the exposure of the lens was delivered, the genetic susceptibilities of the individual exposed, and the location of the opacity relative to the visual axis of the individual. The preponderance of epidemiological evidence suggests that lens damage could occur at lower doses than previously considered and the NCRP has determined that it is prudent to reduce the recommended annual lens of the eye occupational dose limit from an equivalent dose of 150 mSv to an absorbed dose of 50 mGy. Significant additional research is still needed in the following areas: comprehensive evaluation of the overall effects of ionizing radiation on the eye, dosimetry methodology and dose-sparing optimization techniques, additional high quality epidemiology studies, and a basic understanding of the mechanisms of cataract development.
PURPOSE: This review summarizes the conclusions and recommendations of the new National Council on Radiation Protection and Measurements (NCRP) Commentary No. 26 guidance on radiation dose limits for the lens of the eye. The NCRP addressed radiation protection principles in respect to the lens of the eye, discussed the current understanding of eye biology and lens effects, reviewed and evaluated epidemiology, and assessed exposed populations with the potential for significant radiation exposures to the lens while suggesting monitoring and protection practices. CONCLUSIONS: Radiation-induced damage to the lens of the eye can include the loss of clarity resulting in opacification or clouding several years after exposure. The impact is highly dependent on the type of radiation, how the exposure of the lens was delivered, the genetic susceptibilities of the individual exposed, and the location of the opacity relative to the visual axis of the individual. The preponderance of epidemiological evidence suggests that lens damage could occur at lower doses than previously considered and the NCRP has determined that it is prudent to reduce the recommended annual lens of the eye occupational dose limit from an equivalent dose of 150 mSv to an absorbed dose of 50 mGy. Significant additional research is still needed in the following areas: comprehensive evaluation of the overall effects of ionizing radiation on the eye, dosimetry methodology and dose-sparing optimization techniques, additional high quality epidemiology studies, and a basic understanding of the mechanisms of cataract development.
Entities:
Keywords:
National Council on Radiation Protection and Measurements (NCRP); radiation-dose limit for human lenticular opacification; radiation-induced cataract
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