Alyson Haslam1, Sara Wagner Robb1, James R Hébert2, Hanwen Huang1, Michael D Wirth2, Nitin Shivappa2, Mark H Ebell1. 1. 1College of Public Health,Department of Epidemiology and Biostatistics,University of Georgia,101 Buck Road,Health Sciences Campus,B.S. Miller Hall,Athens,GA 30602,USA. 2. 2Cancer Prevention and Control Program and Department of Epidemiology & Biostatistics,Arnold School of Public Health,University of South Carolina,Columbia,SC,USA.
Abstract
OBJECTIVE: The Dietary Inflammatory Index (DII)TM, which was developed to characterize the inflammatory potential of a person's diet, has been shown to be associated with inflammatory conditions such as cancer. The present study aimed to investigate the association between DII scores and colorectal adenoma (CRA), a pre-cancerous condition. DESIGN: Responses to baseline dietary questionnaires were used calculate DII scores. In a cross-sectional study design, the association between DII scores and CRA prevalence was determined in men and women separately using logistic regression models. SETTING: Ten cancer screening centres across the USA. SUBJECTS: Participants were those included in the screening arm of the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial. RESULTS: Among the 44 278 individuals included in these analyses, men with diets in the most inflammatory quartile of DII scores had higher odds of all types of CRA (advanced, non-advanced and multiple (>1)) compared with those with diets in the least inflammatory quartile of DII scores. In fully adjusted models, compared with those with DII scores in quartile 1 (least inflammatory), males with DII scores in quartile 3 (adjusted odds ratio (aOR)=1·28; 95 % CI 1·12, 1·47) and quartile 4 (aOR=1·41; 95 % CI 1·23, 1·62) were more likely to have prevalent distal CRA. Higher DII scores, representing a more inflammatory diet, also were weakly associated with a higher prevalence of CRA in women. CONCLUSIONS: Implementing an anti-inflammatory diet may be an effective means of primary prevention of CRA, especially in men.
OBJECTIVE: The Dietary Inflammatory Index (DII)TM, which was developed to characterize the inflammatory potential of a person's diet, has been shown to be associated with inflammatory conditions such as cancer. The present study aimed to investigate the association between DII scores and colorectal adenoma (CRA), a pre-cancerous condition. DESIGN: Responses to baseline dietary questionnaires were used calculate DII scores. In a cross-sectional study design, the association between DII scores and CRA prevalence was determined in men and women separately using logistic regression models. SETTING: Ten cancer screening centres across the USA. SUBJECTS:Participants were those included in the screening arm of the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial. RESULTS: Among the 44 278 individuals included in these analyses, men with diets in the most inflammatory quartile of DII scores had higher odds of all types of CRA (advanced, non-advanced and multiple (>1)) compared with those with diets in the least inflammatory quartile of DII scores. In fully adjusted models, compared with those with DII scores in quartile 1 (least inflammatory), males with DII scores in quartile 3 (adjusted odds ratio (aOR)=1·28; 95 % CI 1·12, 1·47) and quartile 4 (aOR=1·41; 95 % CI 1·23, 1·62) were more likely to have prevalent distal CRA. Higher DII scores, representing a more inflammatory diet, also were weakly associated with a higher prevalence of CRA in women. CONCLUSIONS: Implementing an anti-inflammatory diet may be an effective means of primary prevention of CRA, especially in men.
Authors: Fangcheng Yuan; Lin Deng; Xiangqing Sun; Zhengyi Chen; Nitin Shivappa; Ashutosh K Sheth; Gregory S Cooper; James R Hebert; Li Li Journal: Cancer Causes Control Date: 2021-04-29 Impact factor: 2.506
Authors: Samyukta Swaminath; Caroline Y Um; Anna E Prizment; DeAnn Lazovich; Roberd M Bostick Journal: Cancer Epidemiol Biomarkers Prev Date: 2018-11-21 Impact factor: 4.254
Authors: Zhuyue Li; Kang Wang; Nitin Shivappa; James R Hébert; Hong Chen; Hui Liu; Xiaolian Jiang Journal: Br J Cancer Date: 2022-02-08 Impact factor: 9.075
Authors: Nitin Shivappa; Justyna Godos; James R Hébert; Michael D Wirth; Gabriele Piuri; Attilio F Speciani; Giuseppe Grosso Journal: Nutrients Date: 2017-09-20 Impact factor: 5.717
Authors: Catherine M Phillips; Ling-Wei Chen; Barbara Heude; Jonathan Y Bernard; Nicholas C Harvey; Liesbeth Duijts; Sara M Mensink-Bout; Kinga Polanska; Giulia Mancano; Matthew Suderman; Nitin Shivappa; James R Hébert Journal: Nutrients Date: 2019-08-12 Impact factor: 5.717