| Literature DB >> 28343846 |
Isaac Rosado-Sánchez1, Inmaculada Jarrín2, María M Pozo-Balado3, Rebeca S de Pablo-Bernal3, Inés Herrero-Fernández3, Ana I Alvarez-Ríos4, Esther Rodríguez-Gallego5, Miguel Genebat3, Mar Vera6, Juan Berenguer7, María L Martín8, Enrique Bernal9, Francesc Vidal5, Julià Blanco10, Manuel Leal3, Yolanda M Pacheco11.
Abstract
Immunological characterization of HIV-infected subjects with low CD4-recovery (LR-subjects) has been extensively performed after a variable period of combined antiretroviral therapy (cART). We now explore immunological alterations present before the cART onset. In a case-control study, we selected pre-cART samples of HIV-subjects with and without low CD4-recovery after cART (n = 21 per group). CD4 T-cell activation, senescence and exhaustion related markers were not found specifically altered before cART initiation. On the other hand, we found that LR-subjects before cART already showed increased levels of IL6 (p = 0.009) and increased frequencies of Ki67+CD4+ T-cells (p = 0.026), CD45RA-CD27+CD4+ T-cells (p = 0.008) and Treg (p = 0.001), as well as increased expression of CD95 and CD127 on CD4 T-cells (p = 0.016; p = 0.032, respectively). These parameters characterize the immunological damage in LR-subjects before the cART onset and could be associated to the mechanisms hindering the subsequent CD4 recovery.Entities:
Keywords: CD4 T-cell homeostasis; Inflammation; Low CD4 recovery; Treg; Turnover; cART
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Year: 2017 PMID： 28343846 DOI： 10.1016/j.antiviral.2017.03.015
Source DB: PubMed Journal: Antiviral Res ISSN： 0166-3542 Impact factor: 5.970