Literature DB >> 283429

Sleep-promoting factor S: purification and properties.

J M Krueger, J R Pappenheimer, M L Karnovsky.   

Abstract

Sleep-promoting factor was purified from acid/acetone extracts of whole brains of rabbits and from brainstems of slaughterhouse cattle. Intraventricular infusion of extracts purified by means of ion exchange and gel filtration induced excess slow-wave sleep in rabbits for 5-10 hr. The procedure is simple and provides material suitable for physiological studies. Further treatment by partition chromatography and electrophoresis yielded an active product that was purified at least 1 million-fold. This product was inactivated by incubation with mixed carboxypeptidases A and B. Amino acid analysis of acid hydrolysates indicated that the effective dose was less than 150 pmol per rabbit and the original concentration in brain tissue was of the order of 30 pmol/g of brain.

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Year:  1978        PMID： 283429      PMCID： PMC336301          DOI： 10.1073/pnas.75.10.5235

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  8 in total

1.  Extraction of sleep-promoting factor S from cerebrospinal fluid and from brains of sleep-deprived animals.

Authors:  J R Pappenheimer; G Koski; V Fencl; M L Karnovsky; J Krueger
Journal:  J Neurophysiol       Date:  1975-11       Impact factor: 2.714

2.  Regional distribution of substance P in the brain of the rat.

Authors:  M J Brownstein; E A Mroz; J S Kizer; M Palkovits; S E Leeman
Journal:  Brain Res       Date:  1976-11-05       Impact factor: 3.252

3.  The relative importance of central nervous catecholaminergic and cholinergic mechanisms in drinking in response to antiotensin and other thirst stimuli.

Authors:  J T Fitzsimons; P E Setler
Journal:  J Physiol       Date:  1975-09       Impact factor: 5.182

4.  Fluorescamine: a reagent for assay of amino acids, peptides, proteins, and primary amines in the picomole range.

Authors:  S Udenfriend; S Stein; P Böhlen; W Dairman; W Leimgruber; M Weigele
Journal:  Science       Date:  1972-11-24       Impact factor: 47.728

5.  Isolation of a sialogogic peptide from bovine hypothalamic tissue and its characterization as substance P.

Authors:  M M Chang; S E Leeman
Journal:  J Biol Chem       Date:  1970-09-25       Impact factor: 5.157

6.  Sleep-promoting effects of cerebrospinal fluid from sleep-deprived goats.

Authors:  J R Pappenheimer; T B Miller; C A Goodrich
Journal:  Proc Natl Acad Sci U S A       Date:  1967-08       Impact factor: 11.205

7.  A naturally occurring delta-EEG enhancing nonapeptide in rabbits. X. Final isolation, characterization and activity test.

Authors:  G A Schoenenberger; P F Maier; J H Tobler; M Monnier
Journal:  Pflugers Arch       Date:  1977-06-08       Impact factor: 3.657

8.  Factors in cerebrospinal fluid from goats that affect sleep and activity in rats.

Authors:  V Fencl; G Koski; J R Pappenheimer
Journal:  J Physiol       Date:  1971-08       Impact factor: 5.182
  8 in total
  5 in total

Review 1.  Role of biological membranes in slow-wave sleep.

Authors:  M L Karnovsky
Journal:  J Bioenerg Biomembr       Date:  1991-02       Impact factor: 2.945

Review 2.  Gut reactions: How the blood-brain barrier connects the microbiome and the brain.

Authors:  Aric F Logsdon; Michelle A Erickson; Elizabeth M Rhea; Therese S Salameh; William A Banks
Journal:  Exp Biol Med (Maywood)       Date:  2017-11-23

Review 3.  The organization and regulation of sleep. A review of the experimental evidence and a novel integrated model of the organizing and regulating apparatus.

Authors:  W P Koella
Journal:  Experientia       Date:  1984-04-15

4.  Qualitative detection of muramic acid in normal mammalian tissues.

Authors:  Z Sen; M L Karnovsky
Journal:  Infect Immun       Date:  1984-03       Impact factor: 3.441

Review 5.  How (and why) the immune system makes us sleep.

Authors:  Luca Imeri; Mark R Opp
Journal:  Nat Rev Neurosci       Date:  2009-02-11       Impact factor: 34.870
  5 in total

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