Sheena I Dev1, Tanya T Nguyen2, Benjamin S McKenna3, Ashley N Sutherland4, Hauke Bartsch5, Rebecca J Theilmann5, Lisa T Eyler6. 1. Research Service, Veterans Affairs San Diego Healthcare System, San Diego, CA; Departments of Psychiatry, University of California, San Diego, CA; San Diego State University/University of California, San Diego Joint Doctoral Program in Clinical Psychology, San Diego, CA. Electronic address: sdev25@gmail.com. 2. Mental Illness Research, Education, and Clinical Center, Veterans Affairs San Diego Healthcare System, San Diego, CA; Departments of Psychiatry, University of California, San Diego, CA. 3. Departments of Psychiatry, University of California, San Diego, CA. 4. Research Service, Veterans Affairs San Diego Healthcare System, San Diego, CA; Departments of Psychiatry, University of California, San Diego, CA. 5. Department of Radiology, University of California, San Diego, CA. 6. Research Service, Veterans Affairs San Diego Healthcare System, San Diego, CA; Departments of Psychiatry, University of California, San Diego, CA; San Diego State University/University of California, San Diego Joint Doctoral Program in Clinical Psychology, San Diego, CA.
Abstract
OBJECTIVES: Bipolar disorder (BD) is associated with compromised white matter (WM) integrity and deficits in processing speed (PS). Few studies, however, have investigated age relationships with WM structure and cognition to understand possible changes in brain health over the lifespan. This investigation explored whether BD and healthy counterpart (HC) participants exhibited differential age-related associations with WM and cognition, which may be suggestive of accelerated brain and cognitive aging. DESIGN: Cross-sectional study. SETTING: University of California San Diego and the Veterans Administration San Diego Healthcare System. PARTICIPANTS: 33 euthymic BD and 38 HC participants. MEASUREMENTS: Diffusion tensor imaging was acquired as a measure of WM integrity, and tract-specific fractional anisotropy (FA) was extracted utilizing the Johns Hopkins University probability atlas. PS was assessed with the Number and Letter Sequencing conditions of the Delis-Kaplan Executive Function System Trail Making Test. RESULTS: BD participants demonstrated slower PS compared with the HC group, but no group differences were found in FA across tracts. Multiple linear regressions revealed a significant group-by-age interaction for the right uncinate fasciculus, the left hippocampal portion of the cingulum, and for PS, such that older age was associated with lower FA values and slower PS in the BD group only. The relationship between age and PS did not significantly change after accounting for uncinate FA, suggesting that the observed age associations occur independently. CONCLUSIONS: Results provide support for future study of the accelerated aging hypothesis by identifying markers of brain health that demonstrate a differential age association in BD.
OBJECTIVES:Bipolar disorder (BD) is associated with compromised white matter (WM) integrity and deficits in processing speed (PS). Few studies, however, have investigated age relationships with WM structure and cognition to understand possible changes in brain health over the lifespan. This investigation explored whether BD and healthy counterpart (HC) participants exhibited differential age-related associations with WM and cognition, which may be suggestive of accelerated brain and cognitive aging. DESIGN: Cross-sectional study. SETTING: University of California San Diego and the Veterans Administration San Diego Healthcare System. PARTICIPANTS: 33 euthymic BD and 38 HC participants. MEASUREMENTS: Diffusion tensor imaging was acquired as a measure of WM integrity, and tract-specific fractional anisotropy (FA) was extracted utilizing the Johns Hopkins University probability atlas. PS was assessed with the Number and Letter Sequencing conditions of the Delis-Kaplan Executive Function System Trail Making Test. RESULTS: BD participants demonstrated slower PS compared with the HC group, but no group differences were found in FA across tracts. Multiple linear regressions revealed a significant group-by-age interaction for the right uncinate fasciculus, the left hippocampal portion of the cingulum, and for PS, such that older age was associated with lower FA values and slower PS in the BD group only. The relationship between age and PS did not significantly change after accounting for uncinate FA, suggesting that the observed age associations occur independently. CONCLUSIONS: Results provide support for future study of the accelerated aging hypothesis by identifying markers of brain health that demonstrate a differential age association in BD.
Authors: Stephen M Smith; Mark Jenkinson; Mark W Woolrich; Christian F Beckmann; Timothy E J Behrens; Heidi Johansen-Berg; Peter R Bannister; Marilena De Luca; Ivana Drobnjak; David E Flitney; Rami K Niazy; James Saunders; John Vickers; Yongyue Zhang; Nicola De Stefano; J Michael Brady; Paul M Matthews Journal: Neuroimage Date: 2004 Impact factor: 6.556
Authors: Heather C Strasser; Jessica Lilyestrom; Ebony R Ashby; Nancy A Honeycutt; David J Schretlen; Ann E Pulver; Ramona O Hopkins; J Raymond Depaulo; James B Potash; Barbara Schweizer; Khara O Yates; Elizabeth Kurian; Patrick E Barta; Godfrey D Pearlson Journal: Biol Psychiatry Date: 2005-03-15 Impact factor: 13.382
Authors: Amy M Kilbourne; Jack R Cornelius; Xiaoyan Han; Harold A Pincus; Mujeeb Shad; Ihsan Salloum; Joseph Conigliaro; Gretchen L Haas Journal: Bipolar Disord Date: 2004-10 Impact factor: 6.744
Authors: P Gallagher; J Nilsson; A Finkelmeyer; M Goshawk; K A Macritchie; A J Lloyd; J M Thompson; R J Porter; A H Young; I N Ferrier; R H McAllister-Williams; S Watson Journal: Psychol Med Date: 2015-06-15 Impact factor: 7.723
Authors: Geoffrey A Kerchner; Caroline A Racine; Sandra Hale; Reva Wilheim; Victor Laluz; Bruce L Miller; Joel H Kramer Journal: PLoS One Date: 2012-11-21 Impact factor: 3.240
Authors: William S Stone; Michael R Phillips; Lawrence H Yang; Lawrence S Kegeles; Ezra S Susser; Jeffrey A Lieberman Journal: Schizophr Res Date: 2022-03-25 Impact factor: 4.662
Authors: Maria A Di Biase; Suheyla Cetin-Karayumak; Amanda E Lyall; Andrew Zalesky; Kang Ik Kevin Cho; Fan Zhang; Marek Kubicki; Yogesh Rathi; Monica G Lyons; Sylvain Bouix; Tashrif Billah; Alan Anticevic; Charlie Schleifer; Brendan D Adkinson; Jie Lisa Ji; Zailyn Tamayo; Jean Addington; Carrie E Bearden; Barbara A Cornblatt; Matcheri S Keshavan; Daniel H Mathalon; Thomas H McGlashan; Diana O Perkins; Kristen S Cadenhead; Ming T Tsuang; Scott W Woods; William S Stone; Martha E Shenton; Tyrone D Cannon; Ofer Pasternak Journal: Mol Psychiatry Date: 2021-05-24 Impact factor: 13.437
Authors: Ellen Lee; Marina Ramsey; Atul Malhotra; Sonia Ancoli-Israel; Christopher N Kaufmann; Benchawanna Soontornniyomkij; Sarah A Graham; Colin Depp; Lisa T Eyler Journal: J Psychiatr Res Date: 2020-12-13 Impact factor: 4.791
Authors: Julia O Linke; Caitlin Stavish; Nancy E Adleman; Joelle Sarlls; Kenneth E Towbin; Ellen Leibenluft; Melissa A Brotman Journal: Bipolar Disord Date: 2020-01-21 Impact factor: 6.744