Literature DB >> 283426

beta-Endorphin induces nonconvulsive limbic seizures.

S J Henriksen, F E Bloom, F McCoy, N Ling, R Guillemin.   

Abstract

The endogenous opioid peptide, beta-endorphin, induces nonconvulsive limbic epileptiform activity when administered intraventricularly to rats. Epileptiform activity is elicited by beta-endorphin in doses that are devoid of analgesic or behavioral signs. Equimolar intraventricular doses of morphine or of the enkephalin analog [DAIa2,Met5]enkephalin-NH2 fail to elicit this limbic epileptiform activity. These observations, together with the recent immunohistochemical localization of beta-endorphin to midline limbic structures, suggest that beta-endorphin may have an important role in the regulation of limbic excitability.

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Year:  1978        PMID： 283426      PMCID： PMC336298          DOI： 10.1073/pnas.75.10.5221

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  27 in total

1.  Isolation, primary structure, and synthesis of alpha-endorphin and gamma-endorphin, two peptides of hypothalamic-hypophysial origin with morphinomimetic activity.

Authors:  N Ling; R Burgus; R Guillemin
Journal:  Proc Natl Acad Sci U S A       Date:  1976-11       Impact factor: 11.205

2.  Different brain areas mediate the analgesic and epileptic properties of enkephalin.

Authors:  H Frenk; B C McCarty; J C Liebeskind
Journal:  Science       Date:  1978-04-21       Impact factor: 47.728

3.  Radioimmunoassay of brain peptides: evaluation of a methodology for the assay of beta-endorphin and enkephalin.

Authors:  J Rossier; A Bayon; T M Vargo; N Ling; R Guillemin; F Bloom
Journal:  Life Sci       Date:  1977-09-15       Impact factor: 5.037

4.  Neuronal actions of endorphins and enkephalins among brain regions: a comparative microiontophoretic study.

Authors:  R A Nicoll; G R Siggins; N Ling; F E Bloom; R Guillemin
Journal:  Proc Natl Acad Sci U S A       Date:  1977-06       Impact factor: 11.205

5.  Neurotensin: immunohistochemical localization in rat central nervous system.

Authors:  G R Uhl; M J Kuhar; S H Snyder
Journal:  Proc Natl Acad Sci U S A       Date:  1977-09       Impact factor: 11.205

6.  Immunocytochemical localization of methionine enkephalin: preliminary observations.

Authors:  S J Watson; H Akil; S Sullivan; J D Barchas
Journal:  Life Sci       Date:  1977-09-01       Impact factor: 5.037

7.  Neurons containing beta-endorphin in rat brain exist separately from those containing enkephalin: immunocytochemical studies.

Authors:  F Bloom; E Battenberg; J Rossier; N Ling; R Guillemin
Journal:  Proc Natl Acad Sci U S A       Date:  1978-03       Impact factor: 11.205

8.  Morphine and enkephalin: analgesic and epileptic properties.

Authors:  G Urca; H Frenk; J C Liebeskind; A N Taylor
Journal:  Science       Date:  1977-07-01       Impact factor: 47.728

9.  Enkephalin-induced depression of single neurons in brain areas with opiate receptors--antagonism by naloxone.

Authors:  R C Frederickson; F H Norris
Journal:  Science       Date:  1976-10-22       Impact factor: 47.728

10.  Analgesia from rostral brain stem stimulation in the rat.

Authors:  D L Rhodes; J C Liebeskind
Journal:  Brain Res       Date:  1978-03-31       Impact factor: 3.252
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  19 in total

Review 1.  Environmental influences on neural plasticity, the limbic system, emotional development and attachment: a review.

Authors:  R Joseph
Journal:  Child Psychiatry Hum Dev       Date:  1999

2.  The effect of naloxone on audiogenic seizures.

Authors:  R A Schreiber
Journal:  Psychopharmacology (Berl)       Date:  1979-11       Impact factor: 4.530

Review 3.  Clinical features, pathogenesis and management of drug-induced seizures.

Authors:  G Zaccara; G C Muscas; A Messori
Journal:  Drug Saf       Date:  1990 Mar-Apr       Impact factor: 5.606

4.  Insulin fragments as a carrier for peptide delivery across the blood-brain barrier.

Authors:  M Fukuta; H Okada; S Iinuma; S Yanai; H Toguchi
Journal:  Pharm Res       Date:  1994-12       Impact factor: 4.200

Review 5.  Enkephalins and Endorphins. Clinical, pharmacological and therapeutic implications.

Authors:  D L Copolov; R D Helme
Journal:  Drugs       Date:  1983-12       Impact factor: 9.546

6.  The excitatory response of in vitro hippocampal pyramidal cells to normorphine and methionine-enkephalin may be mediated by different receptor populations.

Authors:  E D French; W Zieglgänsberger
Journal:  Exp Brain Res       Date:  1982       Impact factor: 1.972

7.  Stress-induced release of prolactin: blockade by dexamethasone and naloxone may indicate beta-endorphin mediation.

Authors:  J Rossier; E French; C Rivier; T Shibasaki; R Guillemin; F E Bloom
Journal:  Proc Natl Acad Sci U S A       Date:  1980-01       Impact factor: 11.205

8.  Developmental and regional alteration of kappa-opioid receptors in seizure-susceptible EL mouse brain.

Authors:  T Kai; H Onishi; S Koide; M Katayama; S Yamagami
Journal:  Neurochem Res       Date:  1998-02       Impact factor: 3.996

9.  Enkephalinase inhibition antagonizes the increased susceptibility to seizure induced by REM sleep deprivation.

Authors:  O E Ukponmwan; M R Dzoljic
Journal:  Psychopharmacology (Berl)       Date:  1984       Impact factor: 4.530

10.  Differential epileptogenic potentials of selective mu and delta opiate receptor agonists.

Authors:  J Haffmans; M R Dzoljic
Journal:  J Neural Transm       Date:  1983       Impact factor: 3.575
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