| Literature DB >> 28342587 |
Suresh Awale1, Ahmed M Tawila2, Dya Fita Dibwe3, Jun-Ya Ueda4, Sijia Sun3, Sirivan Athikomkulchai5, Chandrashaker Balachandran3, Ikuo Saiki6, Kinzo Matsumoto7, Hiroyasu Esumi8.
Abstract
From the chloroform extract of the leaves of Uvaria dac, four new highly-oxygenated cyclohexene derivatives named uvaridacols I-L (1-4) were isolated together with nine previously reported compounds (5-13). Their structures were determined based on the extensive NMR spectroscopic data and circular dichroism spectroscopic analysis. Among the new compounds, uvaridacol L (4) displayed strong preferential cytotoxicity in the nutrient deprived medium against five different tested pancreatic cancer cell lines, PANC-1 (PC50, 20.1μM), PSN-1 (PC50, 9.7μM), MIA PaCa-2 (PC50, 29.1μM), Capan-1 (73.0μM) and KLM-1 (25.9μM).Entities:
Keywords: Antiausterity agents; PANC-1; Pancreatic cancer; Preferential cytotoxicity; Uvaria dac
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Year: 2017 PMID： 28342587 DOI： 10.1016/j.bmcl.2017.03.021
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823