Literature DB >> 283418

Extent of genetic variation at a highly polymorphic esterase locus in Drosophila pseudoobscura.

J A Coyne, A A Felton, R C Lewontin.   

Abstract

The esterase-5 locus of Drosophila pseudoobscura has been screened for variation by using a wide variety of electrophoretic conditions and by testing heat sensitivity. Among 50 isogenic lines from 17 populations, 21 genetic variants were found at the locus, 18 by electrophoresis and 3 by heat denaturation. Including alleles previously known, there are a total of 30 alleles at this locus in natural populations. This represents a doubling of the previous estimates of polymorphism at this locus. The study confirms that, in contrast to monomorphic loci, loci judged polymorphic under one detection procedure show large increases in polymorphism when examined extensively.

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Year:  1978        PMID： 283418      PMCID： PMC336269          DOI： 10.1073/pnas.75.10.5090

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  10 in total

1.  Polyallelic mutational equilibria.

Authors:  J L King; T Ohta
Journal:  Genetics       Date:  1975-04       Impact factor: 4.562

2.  Allelic heterogeneity within allozymes separated by electrophoresis in Drosophila pseudoobscura.

Authors:  R E McDowell; S Prakash
Journal:  Proc Natl Acad Sci U S A       Date:  1976-11       Impact factor: 11.205

3.  Polymorphism for dimerizing ability at the esterase-5 locus in Drosophila pseudoobscura.

Authors:  G Cobbs
Journal:  Genetics       Date:  1976-01       Impact factor: 4.562

4.  Heterosis as an explanation for large amounts of genic polymorphism.

Authors:  R C Lewontin; L R Ginzburg; S D Tuljapurkar
Journal:  Genetics       Date:  1978-01       Impact factor: 4.562

5.  Genic Heterogeneity at Two Alcohol Dehydrogenase Loci in DROSOPHILA PSEUDOOBSCURA and DROSOPHILA PERSIMILIS.

Authors:  J A Coyne; A A Felton
Journal:  Genetics       Date:  1977-10       Impact factor: 4.562

6.  Examination of Allelic Variation at the Hexokinase Loci of DROSOPHILA PSEUDOOBSCURA and D. PERSIMILIS by Different Methods.

Authors:  A T Beckenbach; S Prakash
Journal:  Genetics       Date:  1977-12       Impact factor: 4.562

7.  A molecular approach to the study of genic heterozygosity in natural populations. I. The number of alleles at different loci in Drosophila pseudoobscura.

Authors:  J L Hubby; R C Lewontin
Journal:  Genetics       Date:  1966-08       Impact factor: 4.562

8.  Lack of genic similarity between two sibling species of drosophila as revealed by varied techniques.

Authors:  J A Coyne
Journal:  Genetics       Date:  1976-11       Impact factor: 4.562

9.  Genetic heterogeneity within electrophoretic "alleles" of xanthine dehydrogenase in Drosophila pseudoobscura.

Authors:  R S Singh; R C Lewontin; A A Felton
Journal:  Genetics       Date:  1976-11       Impact factor: 4.562

10.  Genic variation in a natural population of Drosophila persimilis.

Authors:  S Prakash
Journal:  Proc Natl Acad Sci U S A       Date:  1969-03       Impact factor: 11.205
  10 in total
  24 in total

1.  Perturbation-reperturbation test of selection vs. hitchhiking of the two major alleles of Esterase-5 in Drosophila pseudoobscura.

Authors:  E Arnason
Journal:  Genetics       Date:  1991-09       Impact factor: 4.562

2.  Hubby and Lewontin on Protein Variation in Natural Populations: When Molecular Genetics Came to the Rescue of Population Genetics.

Authors:  Brian Charlesworth; Deborah Charlesworth; Jerry A Coyne; Charles H Langley
Journal:  Genetics       Date:  2016-08       Impact factor: 4.562

3.  Macromolecular interaction and the electrophoretic mobility of esterase-5 from Drosophila pseudoobscura.

Authors:  E Arnason; G K Chambers
Journal:  Biochem Genet       Date:  1987-04       Impact factor: 1.890

4.  Mutational analysis of natural alleles in and affecting the B incompatibility factor of Schizophyllum.

Authors:  Y Koltin; J Stamberg; N Bawnik; A Tamarkin; R Werczberger
Journal:  Genetics       Date:  1979-10       Impact factor: 4.562

5.  The sensitivity of gel electrophoresis as a detector of genetic variation.

Authors:  J A Ramshaw; J A Coyne; R C Lewontin
Journal:  Genetics       Date:  1979-12       Impact factor: 4.562

6.  Genic heterogeneity within electrophoretic "alleles" and the pattern of variation among loci in Drosophila pseudoobscura.

Authors:  R S Singh
Journal:  Genetics       Date:  1979-12       Impact factor: 4.562

7.  The Genetics of DROSOPHILA SUBOBSCURA Populations. Xiv. Further Data on Linkage Disequilibria.

Authors:  M Loukas; C B Krimbas; K Morgan
Journal:  Genetics       Date:  1980-07       Impact factor: 4.562

8.  A model to estimate the increase of genetic variability due to electrophoretically cryptic alleles.

Authors:  M Iizuka
Journal:  Genetics       Date:  1988-02       Impact factor: 4.562

9.  Distinctions among allelic variants associated with chromosome 3 inversions in Drosophila pseudoobscura and Drosophila persimilis.

Authors:  R A Norman; S Prakash
Journal:  Genetics       Date:  1980-11       Impact factor: 4.562

10.  Activity variants of acid phosphatase-3 among chromosome 3 inversions of Drosophila pseudoobscura.

Authors:  R A Norman; S Prakash
Journal:  Genetics       Date:  1980-11       Impact factor: 4.562
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