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Literature DB >> 28341760

Intratumoral Heterogeneity in Breast Cancer: A Comparison of Primary and Metastatic Breast Cancers.

Yu-Jie Shi¹, Julia Y S Tsang², Yun-Bi Ni², Gary M Tse³.

Abstract

Intratumoral heterogeneity presents challenges in the management of cancer. To gain deeper insight in intratumoral heterogeneity at different levels and tumor sites for common biomarkers in breast cancers, this report examines seven cases of invasive breast cancer with multiple axillary nodal metastases and/or recurrences for immunohistochemical expression of estrogen receptors, progesterone receptors, human epidermal growth receptor 2, and Ki67 on all tissue blocks in both primary and metastatic tumors. The Oncologist 2017;22:487-490. © AlphaMed Press 2017.

Entities: Disease Species

Keywords: Biomarker; Breast cancer; Immunohistochemistry; Tumor heterogeneity

Mesh：

Substances：

Year: 2017 PMID： 28341760 PMCID： PMC5388387 DOI： 10.1634/theoncologist.2016-0352

Source DB: PubMed Journal: Oncologist ISSN： 1083-7159

9 in total

1. Intratumoral heterogeneity of HER2 gene amplification in breast cancer: its clinicopathological significance.

Authors: Hyesil Seol; Hyun Ju Lee; Yoomi Choi; Hee Eun Lee; Yu Jung Kim; Jee Hyun Kim; Eunyoung Kang; Sung-Won Kim; So Yeon Park
Journal: Mod Pathol Date: 2012-03-02 Impact factor: 7.842

2. Genetic and phenotypic diversity in breast tumor metastases.

Authors: Vanessa Almendro; Hee Jung Kim; Yu-Kang Cheng; Mithat Gönen; Shalev Itzkovitz; Pedram Argani; Alexander van Oudenaarden; Saraswati Sukumar; Franziska Michor; Kornelia Polyak
Journal: Cancer Res Date: 2014-01-21 Impact factor: 12.701

3. Genetic clonal diversity predicts progression to esophageal adenocarcinoma.

Authors: Carlo C Maley; Patricia C Galipeau; Jennifer C Finley; V Jon Wongsurawat; Xiaohong Li; Carissa A Sanchez; Thomas G Paulson; Patricia L Blount; Rosa-Ana Risques; Peter S Rabinovitch; Brian J Reid
Journal: Nat Genet Date: 2006-03-26 Impact factor: 38.330

4. Clinically used breast cancer markers such as estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 are unstable throughout tumor progression.

Authors: Linda Sofie Lindström; Eva Karlsson; Ulla M Wilking; Ulla Johansson; Johan Hartman; Elisabet Kerstin Lidbrink; Thomas Hatschek; Lambert Skoog; Jonas Bergh
Journal: J Clin Oncol Date: 2012-06-18 Impact factor: 44.544

5. Comparison of core needle biopsy (CNB) and surgical specimens for accurate preoperative evaluation of ER, PgR and HER2 status of breast cancer patients.

Authors: Kentaro Tamaki; Hironobu Sasano; Takanori Ishida; Minoru Miyashita; Motohiro Takeda; Masakazu Amari; Nobumitsu Tamaki; Noriaki Ohuchi
Journal: Cancer Sci Date: 2010-09 Impact factor: 6.716

Review 6. Intra-tumour heterogeneity: a looking glass for cancer?

Authors: Andriy Marusyk; Vanessa Almendro; Kornelia Polyak
Journal: Nat Rev Cancer Date: 2012-04-19 Impact factor: 60.716

7. Cellular and genetic diversity in the progression of in situ human breast carcinomas to an invasive phenotype.

Authors: So Yeon Park; Mithat Gönen; Hee Jung Kim; Franziska Michor; Kornelia Polyak
Journal: J Clin Invest Date: 2010-01-25 Impact factor: 14.808

Review 8. Intratumor heterogeneity: evolution through space and time.

Authors: Charles Swanton
Journal: Cancer Res Date: 2012-09-20 Impact factor: 12.701

9. Common protein biomarkers assessed by reverse phase protein arrays show considerable intratumoral heterogeneity in breast cancer tissues.

Authors: Katharina Malinowsky; Mithu Raychaudhuri; Theresa Buchner; Sabrina Thulke; Claudia Wolff; Heinz Höfler; Karl-Friedrich Becker; Stefanie Avril
Journal: PLoS One Date: 2012-07-05 Impact factor: 3.240

9 in total

4 in total