G C Chiang1, X Mao2, G Kang2, E Chang2, S Pandya2, S Vallabhajosula2, R Isaacson3, L D Ravdin3, D C Shungu2. 1. From the Departments of Radiology (G.C.C., X.M., G.K., E.C., S.P., S.V., D.C.S.) gcc9004@med.cornell.edu. 2. From the Departments of Radiology (G.C.C., X.M., G.K., E.C., S.P., S.V., D.C.S.). 3. Neurology (R.I., L.D.R.), Weill Cornell Medical College, NewYork-Presbyterian Hospital, New York, New York.
Abstract
BACKGROUND AND PURPOSE: Oxidative stress has been implicated as an important pathologic mechanism in the development of Alzheimer disease. The purpose of this study was to assess whether glutathione levels, detected noninvasively with proton MR spectroscopy, are associated with brain amyloidosis and memory in a community-dwelling cohort of healthy older adults. MATERIALS AND METHODS: Fifteen cognitively healthy subjects were prospectively enrolled in this study. All subjects underwent 1H-MR spectroscopy of glutathione, a positron-emission tomography scan with an amyloid tracer, and neuropsychological testing by using the Repeatable Battery for the Assessment of Neuropsychological Status. Associations among glutathione levels, brain amyloidosis, and memory were assessed by using multivariate regression models. RESULTS: Lower glutathione levels were associated with greater brain amyloidosis in the temporal (P = .03) and parietal (P = .05) regions, adjusted for apolipoprotein E ε4 carrier status. There were no significant associations between glutathione levels and cognitive scores. CONCLUSIONS: This study found an association between cortical glutathione levels and brain amyloidosis in healthy older adults, suggesting a potential role for 1H-MR spectroscopy measures of glutathione as a noninvasive biomarker of early Alzheimer disease pathogenesis.
BACKGROUND AND PURPOSE: Oxidative stress has been implicated as an important pathologic mechanism in the development of Alzheimer disease. The purpose of this study was to assess whether glutathione levels, detected noninvasively with proton MR spectroscopy, are associated with brain amyloidosis and memory in a community-dwelling cohort of healthy older adults. MATERIALS AND METHODS: Fifteen cognitively healthy subjects were prospectively enrolled in this study. All subjects underwent 1H-MR spectroscopy of glutathione, a positron-emission tomography scan with an amyloid tracer, and neuropsychological testing by using the Repeatable Battery for the Assessment of Neuropsychological Status. Associations among glutathione levels, brain amyloidosis, and memory were assessed by using multivariate regression models. RESULTS: Lower glutathione levels were associated with greater brain amyloidosis in the temporal (P = .03) and parietal (P = .05) regions, adjusted for apolipoprotein E ε4 carrier status. There were no significant associations between glutathione levels and cognitive scores. CONCLUSIONS: This study found an association between cortical glutathione levels and brain amyloidosis in healthy older adults, suggesting a potential role for 1H-MR spectroscopy measures of glutathione as a noninvasive biomarker of early Alzheimer disease pathogenesis.
Authors: K Herholz; E Salmon; D Perani; J C Baron; V Holthoff; L Frölich; P Schönknecht; K Ito; R Mielke; E Kalbe; G Zündorf; X Delbeuck; O Pelati; D Anchisi; F Fazio; N Kerrouche; B Desgranges; F Eustache; B Beuthien-Baumann; C Menzel; J Schröder; T Kato; Y Arahata; M Henze; W D Heiss Journal: Neuroimage Date: 2002-09 Impact factor: 6.556
Authors: E C Mormino; J T Kluth; C M Madison; G D Rabinovici; S L Baker; B L Miller; R A Koeppe; C A Mathis; M W Weiner; W J Jagust Journal: Brain Date: 2008-11-28 Impact factor: 13.501
Authors: N Weiduschat; X Mao; J Hupf; N Armstrong; G Kang; D J Lange; H Mitsumoto; D C Shungu Journal: Neurosci Lett Date: 2014-04-24 Impact factor: 3.046
Authors: Susan M Landau; Christopher Breault; Abhinay D Joshi; Michael Pontecorvo; Chester A Mathis; William J Jagust; Mark A Mintun Journal: J Nucl Med Date: 2012-11-19 Impact factor: 10.057
Authors: Matthew Geramita; Jan Willem van der Veen; Alan S Barnett; Antonina A Savostyanova; Jun Shen; Daniel R Weinberger; Stefano Marenco Journal: NMR Biomed Date: 2011-02-03 Impact factor: 4.044
Authors: Gary W Small; Prabha Siddarth; Alison C Burggren; Vladimir Kepe; Linda M Ercoli; Karen J Miller; Helen Lavretsky; Paul M Thompson; Greg M Cole; S C Huang; Michael E Phelps; Susan Y Bookheimer; Jorge R Barrio Journal: Arch Gen Psychiatry Date: 2009-01
Authors: Georg Oeltzschner; S Andrea Wijtenburg; Mark Mikkelsen; Richard A E Edden; Peter B Barker; Jin Hui Joo; Jeannie-Marie S Leoutsakos; Laura M Rowland; Clifford I Workman; Gwenn S Smith Journal: Neurobiol Aging Date: 2018-09-27 Impact factor: 4.673
Authors: Paul J Derry; Muralidhar L Hegde; George R Jackson; Rakez Kayed; James M Tour; Ah-Lim Tsai; Thomas A Kent Journal: Prog Neurobiol Date: 2019-10-08 Impact factor: 11.685
Authors: Ashley I Bush; Scott Ayton; Abdel Ali Belaidi; Shashank Masaldan; Adam Southon; Pawel Kalinowski; Karla Acevedo; Ambili T Appukuttan; Stuart Portbury; Peng Lei; Puja Agarwal; Sue E Leurgans; Julie Schneider; Marcus Conrad Journal: Mol Psychiatry Date: 2022-04-28 Impact factor: 15.992
Authors: Brent R Stockwell; José Pedro Friedmann Angeli; Hülya Bayir; Ashley I Bush; Marcus Conrad; Scott J Dixon; Simone Fulda; Sergio Gascón; Stavroula K Hatzios; Valerian E Kagan; Kay Noel; Xuejun Jiang; Andreas Linkermann; Maureen E Murphy; Michael Overholtzer; Atsushi Oyagi; Gabriela C Pagnussat; Jason Park; Qitao Ran; Craig S Rosenfeld; Konstantin Salnikow; Daolin Tang; Frank M Torti; Suzy V Torti; Shinya Toyokuni; K A Woerpel; Donna D Zhang Journal: Cell Date: 2017-10-05 Impact factor: 41.582