| Literature DB >> 28341205 |
Yulong Cai1, Lian Wang1, Rui Xiao1, Xin Li1, Xie He1, Junwei Gao1, Haiwei Xu2, Xiaotang Fan3.
Abstract
Autism spectrum disorder (ASD) is a developmental disorder that is characterized by symptoms of impaired social interactions, restricted interests and repetitive behaviors. Recent studies in humans and animal-models suggest that reduced GABAergic neurotransmission in the brain may underlie autism-related behavioral symptoms. It has been shown that propofol, a commonly used anesthetic, facilitates γ-aminobutyric acid-mediated inhibitory synaptic transmission. The present study investigated whether propofol improved autistic phenotypes in BTBR T + Itpr3tf/J (BTBR) mice, a model of idiopathic autism. We found that i.p. injection of propofol in BTBR mice significantly improved aspects of social approach and repetitive behaviors without affecting reciprocal social interactions and without any detrimental effects in C57BL/6J mice. The ability of propofol to improve autistic phenotypes in BTBR mice through GABAergic neurotransmission suggests a potential pharmacological target for interventions to treat symptoms of autism.Entities:
Keywords: Autism spectrum disorder; Propofol; Repetitive behaviors; Social approach
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Year: 2017 PMID： 28341205 DOI： 10.1016/j.neuropharm.2017.03.021
Source DB: PubMed Journal: Neuropharmacology ISSN： 0028-3908 Impact factor: 5.250