Literature DB >> 2834030

Inhibition of calcium pyrophosphate dihydrate crystal formation: effects of carboxylate ions.

P T Cheng1, K P Pritzker.   

Abstract

Proteoglycans are recognized to inhibit calcium pyrophosphate dihydrate (CPPD) crystal formation but the mechanisms are not known. To study the role of carboxylate (-CO2-) ligands, the possible inhibitor effects of sodium acetate, sodium D-glucuronate, disodium malate, and trisodium citrate were studied using solution mixtures containing [Ca2+] = 1.5 mM, [Mg2+] = 0.5 mM, [PPi] = 0.1 mM, [Pi] = 0.1 mM, [Na+] = 140 mM, 37 degrees C, pH 7.4 with or without 9.5 +/- 0.5 mg CPPD (seed) crystals. These studies showed that monocarboxylates (acetate, glucuronate) have little inhibitive effect. Progressively greater inhibition was found with dicarboxylate (malate) and tricarboxylate (citrate) indicating that the arrangement of carboxylate (and sulfate) ligands on proteoglycan is more important than the inhibitory effect of individual ligands.

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Year:  1988        PMID： 2834030     DOI： 10.1007/BF02555838

Source DB:  PubMed          Journal:  Calcif Tissue Int        ISSN： 0171-967X            Impact factor:   4.333


  17 in total

1.  Effect of proteoglycans on in vitro hydroxyapatite formation.

Authors:  N C Blumenthal; A S Posner; L D Silverman; L C Rosenberg
Journal:  Calcif Tissue Int       Date:  1979-03-13       Impact factor: 4.333

Review 2.  Proteoglycan structure in calcifying cartilage.

Authors:  J A Buckwalter
Journal:  Clin Orthop Relat Res       Date:  1983 Jan-Feb       Impact factor: 4.176

Review 3.  Crystals, joints, and consternation.

Authors:  D McCarty
Journal:  Ann Rheum Dis       Date:  1983-06       Impact factor: 19.103

4.  Precipitation of calcium phosphates from electrolyte solutions. V. The influence of citrate ions.

Authors:  L Brecević; H Füredi-Milhofer
Journal:  Calcif Tissue Int       Date:  1979-10-31       Impact factor: 4.333

5.  The glycosaminoglycans of articular cartilage in calcium pyrophosphate dihydrate (CPPD) crystal deposition disease (chondrocalcinosis articularis or pyrophosphate arthropathy).

Authors:  A O Bjelle
Journal:  Calcif Tissue Res       Date:  1973

6.  Crystal-associated arthropathies: what's new in old joints.

Authors:  K P Pritzker
Journal:  J Am Geriatr Soc       Date:  1980-10       Impact factor: 5.562

7.  Calcium pyrophosphate crystal deposition. An in vitro study using a gelatin matrix model.

Authors:  N S Mandel; G S Mandel; D J Carroll; P B Halverson
Journal:  Arthritis Rheum       Date:  1984-07

8.  Calcium pyrophosphate crystal formation in model hydrogels. II. Hyaline articular cartilage as a gel.

Authors:  K P Pritzker; P T Cheng; S A Omar; S C Nyburg
Journal:  J Rheumatol       Date:  1981 May-Jun       Impact factor: 4.666

9.  Inhibition of hydroxyapatite formation in collagen gels by chondroitin sulphate.

Authors:  G K Hunter; B L Allen; M D Grynpas; P T Cheng
Journal:  Biochem J       Date:  1985-06-01       Impact factor: 3.857

10.  Pyrophosphate, phosphate ion interaction: effects on calcium pyrophosphate and calcium hydroxyapatite crystal formation in aqueous solutions.

Authors:  P T Cheng; K P Pritzker
Journal:  J Rheumatol       Date:  1983-10       Impact factor: 4.666
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  2 in total

1.  Novel ANKH amino terminus mutation (Pro5Ser) associated with early-onset calcium pyrophosphate disease with associated phosphaturia.

Authors:  Barry L Gruber; Ana Rita Couto; Jácome Bruges Armas; Matthew A Brown; Kathleen Finzel; Robert A Terkeltaub
Journal:  J Clin Rheumatol       Date:  2012-06       Impact factor: 3.517

2.  Synovial fluid pyrophosphate and nucleoside triphosphate pyrophosphatase: comparison between normal and diseased and between inflamed and non-inflamed joints.

Authors:  M Pattrick; E Hamilton; J Hornby; M Doherty
Journal:  Ann Rheum Dis       Date:  1991-04       Impact factor: 19.103
  2 in total

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