Agnieszka Perkowska-Ptasinska1, Artur Bartczak2, Malgorzata Wagrowska-Danilewicz3, Agnieszka Halon4, Krzysztof Okon5, Aldona Wozniak6, Marian Danilewicz3, Henryk Karkoszka7, Andrzej Marszalek8, Jolanta Kowalewska9, Andrzej Mroz2, Agnieszka Korolczuk10, Andrzej Oko11, Alicja Debska-Slizien12, Beata Naumnik13, Zbigniew Hruby14, Marian Klinger15, Kazimierz Ciechanowski16, Marek Myslak17, Wladyslaw Sulowicz18, Andrzej Rydzewski19, Andrzej Wiecek20, Jacek Manitius21, Tadeusz Gregorczyk22, Stanislaw Niemczyk23, Michal Nowicki24,25, Ryszard Gellert26, Tomasz Stompor27, Monika Wieliczko28, Krzysztof Marczewski29, Leszek Paczek30, Olga Rostkowska1, Dominika Deborska-Materkowska1, Grazyna Bogdanowicz31, Andrzej Milkowski32, Magdalena Durlik1. 1. Department of Transplantology, Nephrology and Internal Medicine, Medical University of Warsaw, Warsaw, Poland. 2. Department of Pathology, Medical Center of Postgraduate Education, Warsaw, Poland. 3. Department of Pathology, Uniwersytet Medyczny w Lodzi, Lodz, Poland. 4. Department of Pathomorphology, Wroclaw Medical University, Wroclaw, Poland. 5. Department of Clinical and Experimental Pathology, Jagiellonian University, Collegium Medicum, Krakow, Poland. 6. Biopsy Diagnostics Laboratory, Poznan University of Medical Sciences, Poznan, Poland. 7. Nephrology, Endocrinology and Metabolic Diseases, Medical University of Silesia, Katowice, Katowice, Poland. 8. Department of Pathomorphology, Nicolaus Copernicus University, Bydgoszcz, Poland. 9. Department of Pathology, Eastern Virginia Medical School, Norfolk, VA, USA. 10. Pathology Department, Uniwersytet Medyczny w Lublinie, Lublin, Poland. 11. Department of Nephrology, Transplantology, and Internal Medicine, Poznan University of Medical Sciences, Poznan, Poland. 12. Department of Nephrology, Transplantation and Internal Medicine, Medical University of Gdansk, Gdansk, Poland. 13. Department of Nephrology and Transplantology with Dialysis Unit, Medical University Bialystok, Bialystok, Poland. 14. Department of Nephrology, with subdivision of Diabetology and Transplantology, District Specialist Hospital in Wroclaw, Wroclaw, Poland. 15. Department of Nephrology and Transplantation Medicine, Wroclaw Medical University, Wroclaw, Poland. 16. Clinic of Nephrology, Transplantology and Internal Diseases, Pomeranian Medical University, Szczecin, Poland. 17. Department of Nephrology and Kidney Transplantation, District Hospital in Szczecin, Szczecin, Poland. 18. Department of Nephrology, Jagiellonian University, Krakow, Poland. 19. Department of Internal Diseases, Nephrology and Transplantology, Central Clinical Hospital of the Ministry of Interior, Warsaw, Poland. 20. Department of Nephrology, Silesian School of Medicine, Katowice, Poland. 21. Department of Nephrology, Hypertension and Internal Medicine, Collegium Medicum UMK, Bydgoszcz, Poland. 22. Department of Nephrology, District Hospital in Kielce, Kielce, Poland. 23. Department of Internal Diseases, Nephrology and Dialysis, Military Institute of Medicine, Warsaw, Poland. 24. Department of Nephrology, Hypertension and Kidney Transplantation, Medical University of Lodz, Lodz, Poland. 25. Nephrology and Dialysis, Polish Mother's Memorial Hospital, Lodz, Poland. 26. Department of Nephrology, Medical Center for Postgraduate Education, Warsaw, Poland. 27. PD Unit, Chair and Department of Nephrology, Jagiellonian University, Cracow, Poland. 28. Department of Nephrology, Dialysis, and Internal Diseases, Medical University of Warsaw, Warsaw, Poland. 29. Zaklad Etyki i Filozofii Czlowieka, Uniwersytet Medyczny w Lublinie, Lublinie, Poland. 30. Department of Immunology, Transplant Medicine, and Internal Diseases, Medical University of Warsaw, Warsaw, Poland. 31. Department of Nephrology, Regional Medical Centre in Opole, Poland. 32. Dialysis Centre, Fresenius Nephrocare in Krakow, Poland.
Abstract
BACKGROUND: This is the first report on the epidemiology of biopsy-proven kidney diseases in Poland. METHODS: The Polish Registry of Renal Biopsies has collected information on all (n = 9394) native renal biopsies performed in Poland from 2009 to 2014. Patients' clinical data collected at the time of biopsy, and histopathological diagnoses were used for epidemiological and clinicopathologic analysis. RESULTS: There was a gradual increase in the number of native renal biopsies performed per million people (PMP) per year in Poland in 2009-14, starting from 36 PMP in 2009 to 44 PMP in 2014. A considerable variability between provinces in the mean number of biopsies performed in the period covered was found, ranging from 5 to 77 PMP/year. The most common renal biopsy diagnoses in adults were immunoglobulin A nephropathy (IgAN) (20%), focal segmental glomerulosclerosis (FSGS) (15%) and membranous glomerulonephritis (MGN) (11%), whereas in children, minimal change disease (22%), IgAN (20%) and FSGS (10%) were dominant. Due to insufficient data on the paediatric population, the clinicopathologic analysis was limited to patients ≥18 years of age. At the time of renal biopsy, the majority of adult patients presented nephrotic-range proteinuria (45.2%), followed by urinary abnormalities (38.3%), nephritic syndrome (13.8%) and isolated haematuria (1.7%). Among nephrotic patients, primary glomerulopathies dominated (67.6% in those 18-64 years of age and 62.4% in elderly patients) with leading diagnoses being MGN (17.1%), FSGS (16.2%) and IgAN (13.0%) in the younger cohort and MGN (23.5%), amyloidosis (18.8%) and FSGS (16.8%) in the elderly cohort. Among nephritic patients 18-64 years of age, the majority (55.9%) suffered from primary glomerulopathies, with a predominance of IgAN (31.3%), FSGS (12.7%) and crescentic GN (CGN) (11.1%). Among elderly nephritic patients, primary and secondary glomerulopathies were equally common (41.9% each) and pauci-immune GN (24.7%), CGN (20.4%) and IgAN (14.0%) were predominant. In both adult cohorts, urinary abnormalities were mostly related to primary glomerulopathies (66.8% in younger and 50% in elderly patients) and the leading diagnoses were IgAN (31.4%), FSGS (15.9%), lupus nephritis (10.7%) and FSGS (19.2%), MGN (15.1%) and pauci-immune GN (12.3%), respectively. There were significant differences in clinical characteristics and renal biopsy findings between male and female adult patients. CONCLUSIONS: The registry data focused new light on the epidemiology of kidney diseases in Poland. These data should be used in future follow-up and prospective studies.
BACKGROUND: This is the first report on the epidemiology of biopsy-proven kidney diseases in Poland. METHODS: The Polish Registry of Renal Biopsies has collected information on all (n = 9394) native renal biopsies performed in Poland from 2009 to 2014. Patients' clinical data collected at the time of biopsy, and histopathological diagnoses were used for epidemiological and clinicopathologic analysis. RESULTS: There was a gradual increase in the number of native renal biopsies performed per million people (PMP) per year in Poland in 2009-14, starting from 36 PMP in 2009 to 44 PMP in 2014. A considerable variability between provinces in the mean number of biopsies performed in the period covered was found, ranging from 5 to 77 PMP/year. The most common renal biopsy diagnoses in adults were immunoglobulin A nephropathy (IgAN) (20%), focal segmental glomerulosclerosis (FSGS) (15%) and membranous glomerulonephritis (MGN) (11%), whereas in children, minimal change disease (22%), IgAN (20%) and FSGS (10%) were dominant. Due to insufficient data on the paediatric population, the clinicopathologic analysis was limited to patients ≥18 years of age. At the time of renal biopsy, the majority of adult patients presented nephrotic-range proteinuria (45.2%), followed by urinary abnormalities (38.3%), nephritic syndrome (13.8%) and isolated haematuria (1.7%). Among nephrotic patients, primary glomerulopathies dominated (67.6% in those 18-64 years of age and 62.4% in elderly patients) with leading diagnoses being MGN (17.1%), FSGS (16.2%) and IgAN (13.0%) in the younger cohort and MGN (23.5%), amyloidosis (18.8%) and FSGS (16.8%) in the elderly cohort. Among nephritic patients 18-64 years of age, the majority (55.9%) suffered from primary glomerulopathies, with a predominance of IgAN (31.3%), FSGS (12.7%) and crescentic GN (CGN) (11.1%). Among elderly nephritic patients, primary and secondary glomerulopathies were equally common (41.9% each) and pauci-immune GN (24.7%), CGN (20.4%) and IgAN (14.0%) were predominant. In both adult cohorts, urinary abnormalities were mostly related to primary glomerulopathies (66.8% in younger and 50% in elderly patients) and the leading diagnoses were IgAN (31.4%), FSGS (15.9%), lupus nephritis (10.7%) and FSGS (19.2%), MGN (15.1%) and pauci-immune GN (12.3%), respectively. There were significant differences in clinical characteristics and renal biopsy findings between male and female adult patients. CONCLUSIONS: The registry data focused new light on the epidemiology of kidney diseases in Poland. These data should be used in future follow-up and prospective studies.
Authors: Wim Laurens; Dries Deleersnijder; Amélie Dendooven; Evelyne Lerut; An S De Vriese; Tom Dejagere; Mark Helbert; Rachel Hellemans; Priyanka Koshy; Bart Maes; Lissa Pipeleers; Amaryllis H Van Craenenbroeck; Steven Van Laecke; Johan Vande Walle; Marie M Coutteneye; Johan De Meester; Ben Sprangers Journal: Clin Kidney J Date: 2022-01-29
Authors: Aleksandra Musiała; Piotr Donizy; Hanna Augustyniak-Bartosik; Katarzyna Jakuszko; Mirosław Banasik; Katarzyna Kościelska-Kasprzak; Magdalena Krajewska; Dorota Kamińska Journal: J Clin Med Date: 2022-06-08 Impact factor: 4.964
Authors: Maciej Goździk; Agnieszka Płuciennik; Anna Zawiasa-Bryszewska; Maja Nowicka; Zuzanna Nowicka; Małgorzata Wągrowska-Danilewicz; Ilona Kurnatowska Journal: Drug Saf Case Rep Date: 2019-10-05
Authors: Amélie Dendooven; Han Peetermans; Mark Helbert; Tri Q Nguyen; Niels Marcussen; Michio Nagata; Loreto Gesualdo; Agnieszka Perkowska-Ptasinska; Cristina Capusa; Juan M López-Gómez; Colin Geddes; Myrurgia A Abdul-Hamid; Mårten Segelmark; Rosnawati Yahya; Mariela Garau; Russell Villanueva; Anthony Dorman; Sean Barbour; Ronald Cornet; Helmut Hopfer; Kerstin Amann; Sabine Leh Journal: BMC Nephrol Date: 2021-05-24 Impact factor: 2.388