Literature DB >> 28337498

Palladium-catalyzed intermolecular amination of unactivated C(sp3)-H bonds via a cleavable directing group.

Lianwen Jin1, Xiaoli Zeng1, Siyang Li1, Xuechuan Hong1, Guofu Qiu1, Peng Liu1.   

Abstract

Palladium-catalyzed intermolecular amination of unactivated C(sp3)-H bonds was developed. Using NFSI as both the amino source and the oxidant, this protocol operates under mild conditions with excellent terminal selectivity and a broad substrate scope. Moreover, the directing group can be easily removed to produce 1,2-amino alcohols.

Entities:  

Year:  2017        PMID： 28337498     DOI： 10.1039/c7cc00808b

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  4 in total

1.  Ligand-Enabled β-Methylene C(sp3 )-H Arylation of Masked Aliphatic Alcohols.

Authors:  Guoqin Xia; Zhe Zhuang; Luo-Yan Liu; Stuart L Schreiber; Bruno Melillo; Jin-Quan Yu
Journal:  Angew Chem Int Ed Engl       Date:  2020-03-11       Impact factor: 15.336

2.  Hemilabile Benzyl Ether Enables γ-C(sp3)-H Carbonylation and Olefination of Alcohols.

Authors:  Keita Tanaka; William R Ewing; Jin-Quan Yu
Journal:  J Am Chem Soc       Date:  2019-09-18       Impact factor: 15.419

Review 3.  sp3 C-H activation via exo-type directing groups.

Authors:  Yan Xu; Guangbin Dong
Journal:  Chem Sci       Date:  2018-01-17       Impact factor: 9.825

4.  Diastereoconvergent synthesis of anti-1,2-amino alcohols with N-containing quaternary stereocenters via selenium-catalyzed intermolecular C-H amination.

Authors:  Tianyi Zheng; Janna L Berman; Forrest E Michael
Journal:  Chem Sci       Date:  2022-08-03       Impact factor: 9.969
  4 in total

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