Literature DB >> 2833727

Close physical linkage of the murine Ren-1 and Ren-2 loci.

K J Abel1, K W Gross.   

Abstract

In addition to the Ren-1 gene common to all mice, some inbred strains carry a second copy of the renin structural gene, Ren-2. These two loci are tightly linked genetically on mouse chromosome one. We have used pulsed field gel electrophoresis (PFGE) to study the physical arrangement of the two renin genes in the inbred strain DBA/2. PFGE mapping permitted the construction of a restriction map of the Ren loci spanning roughly 120 Kb. The results indicate that the genes are transcribed in the same relative direction, that Ren-2 lies upstream relative to Ren-1, and that the respective coding sequences are separated by approximately 20 Kb.

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Year:  1988        PMID： 2833727      PMCID： PMC338203          DOI： 10.1093/nar/16.5.2111

Source DB:  PubMed          Journal:  Nucleic Acids Res        ISSN： 0305-1048            Impact factor:   16.971


  29 in total

1.  Mapping of the class II region of the human major histocompatibility complex by pulsed-field gel electrophoresis.

Authors:  D A Hardy; J I Bell; E O Long; T Lindsten; H O McDevitt
Journal:  Nature       Date:  1986 Oct 2-8       Impact factor: 49.962

2.  Electrophoretic separations of large DNA molecules by periodic inversion of the electric field.

Authors:  G F Carle; M Frank; M V Olson
Journal:  Science       Date:  1986-04-04       Impact factor: 47.728

3.  A large inverted duplication allows homologous recombination between chromosomes heterozygous for the proximal t complex inversion.

Authors:  B G Herrmann; D P Barlow; H Lehrach
Journal:  Cell       Date:  1987-03-13       Impact factor: 41.582

4.  Fractionation of large mammalian DNA restriction fragments using vertical pulsed-field gradient gel electrophoresis.

Authors:  K Gardiner; W Laas; D Patterson
Journal:  Somat Cell Mol Genet       Date:  1986-03

5.  Ren-1 and Ren-2 loci are expressed in mouse kidney.

Authors:  L J Field; K W Gross
Journal:  Proc Natl Acad Sci U S A       Date:  1985-09       Impact factor: 11.205

6.  Evolution and variation of renin genes in mice.

Authors:  D P Dickinson; K W Gross; N Piccini; C M Wilson
Journal:  Genetics       Date:  1984-11       Impact factor: 4.562

7.  Mouse kidney and submaxillary gland renin genes differ in their 5' putative regulatory sequences.

Authors:  J J Panthier; M Dreyfus; T L Roux; F Rougeon
Journal:  Proc Natl Acad Sci U S A       Date:  1984-09       Impact factor: 11.205

8.  Expression of tissue-specific Ren-1 and Ren-2 genes of mice: comparative analysis of 5'-proximal flanking regions.

Authors:  L J Field; W M Philbrick; P N Howles; D P Dickinson; R A McGowan; K W Gross
Journal:  Mol Cell Biol       Date:  1984-11       Impact factor: 4.272

9.  Molecular cloning of two distinct renin genes from the DBA/2 mouse.

Authors:  J J Mullins; D W Burt; J D Windass; P McTurk; H George; W J Brammar
Journal:  EMBO J       Date:  1982       Impact factor: 11.598

10.  The mouse Rn locus: S allele of the renin regulator gene results from a single structural gene duplication.

Authors:  J J Panthier; I Holm; F Rougeon
Journal:  EMBO J       Date:  1982       Impact factor: 11.598
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  10 in total

1.  Targeted integration of the Ren-1D locus in mouse embryonic stem cells.

Authors:  C C Miller; J C McPheat; W J Potts
Journal:  Proc Natl Acad Sci U S A       Date:  1992-06-01       Impact factor: 11.205

2.  A genetically clamped renin transgene for the induction of hypertension.

Authors:  Kathleen M I Caron; Leighton R James; Hyung-Suk Kim; Scott G Morham; Maria Luisa S Sequeira Lopez; R Ariel Gomez; Timothy L Reudelhuber; Oliver Smithies
Journal:  Proc Natl Acad Sci U S A       Date:  2002-05-28       Impact factor: 11.205

3.  Normotensive blood pressure in mice with a disrupted renin Ren-1d gene.

Authors:  F Bertaux; W H Colledge; S E Smith; M Evans; N J Samani; C C Miller
Journal:  Transgenic Res       Date:  1997-05       Impact factor: 2.788

4.  DNA insertions distinguish the duplicated renin genes of DBA/2 and M. hortulanus mice.

Authors:  K J Abel; P N Howles; K W Gross
Journal:  Mamm Genome       Date:  1992       Impact factor: 2.957

5.  Chronic hypertension and altered baroreflex responses in transgenic mice containing the human renin and human angiotensinogen genes.

Authors:  D C Merrill; M W Thompson; C L Carney; B P Granwehr; G Schlager; J E Robillard; C D Sigmund
Journal:  J Clin Invest       Date:  1996-02-15       Impact factor: 14.808

6.  A single nucleotide mutation in the mouse renin promoter disrupts blood pressure regulation.

Authors:  Keiji Tanimoto; Akiko Sugiura; Sumiyo Kanafusa; Tomoko Saito; Naoto Masui; Kazuyuki Yanai; Akiyoshi Fukamizu
Journal:  J Clin Invest       Date:  2008-03       Impact factor: 14.808

7.  Differential extra-renal expression of the mouse renin genes.

Authors:  C C Miller; A T Carter; J I Brooks; R H Lovell-Badge; W J Brammar
Journal:  Nucleic Acids Res       Date:  1989-04-25       Impact factor: 16.971

8.  Phenotypic dissection of the mouse Ren1d knockout by complementation with human renin.

Authors:  Charlotte Buckley; Robert J Nelson; Linda J Mullins; Matthew G F Sharp; Stewart Fleming; Christopher J Kenyon; Sabrina Semprini; Dominik Steppan; Janos Peti-Peterdi; Armin Kurtz; Helen Christian; John J Mullins
Journal:  J Biol Chem       Date:  2017-11-09       Impact factor: 5.157

9.  Expression of the DBA/2J Ren-2 gene in the adrenal gland of transgenic mice.

Authors:  J J Mullins; C D Sigmund; C Kane-Haas; K W Gross; R A McGowan
Journal:  EMBO J       Date:  1989-12-20       Impact factor: 11.598

Review 10.  Renin and the IGFII/M6P receptor system in cardiac biology.

Authors:  Jacqueline Heger; Klaus-Dieter Schlüter
Journal:  ScientificWorldJournal       Date:  2013-10-27
  10 in total

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