Javier Gomez-Pilar1, Alba Lubeiro2, Jesús Poza3, Roberto Hornero3, Marta Ayuso4, César Valcárcel5, Karim Haidar5, José A Blanco6, Vicente Molina7. 1. Biomedical Engineering Group, Department TSCIT, ETS Ingenieros de Telecomunicación, University of Valladolid, Spain. 2. Psychiatry Department, School of Medicine, University of Valladolid, Spain. 3. Biomedical Engineering Group, Department TSCIT, ETS Ingenieros de Telecomunicación, University of Valladolid, Spain; Instituto de Investigación en Matemática (IMUVA), University of Valladolid, Spain; Neuroscience Institute of Castilla y León (INCYL), University of Salamanca, Spain. 4. Clinical Neurophysiology Service, University Hospital of Valladolid, Valladolid, Spain. 5. Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Spain; Psychiatry Service, University Hospital of Alava, Spain. 6. Psychiatry Service, University Hospital of Valladolid, Valladolid, Spain. 7. Neuroscience Institute of Castilla y León (INCYL), University of Salamanca, Spain; Psychiatry Service, University Hospital of Valladolid, Valladolid, Spain.. Electronic address: vicente.molina@uva.es.
Abstract
OBJECTIVE: Higher mental functions depend on global cerebral functional coordination. Our aim was to study fast modulation of functional networks in schizophrenia that has not been previously assessed. METHODS: Graph-theory was used to analyze the electroencephalographic (EEG) activity during an odd-ball task in 57 schizophrenia patients (18 first episode patients, FEPs) and 59 healthy controls. Clustering coefficient (CLC), characteristic path length (PL) and small-worldness (SW) were computed at baseline ([-300 0] ms prior to stimulus delivery) and response ([150 450] ms post-stimulus) windows. Clinical and cognitive assessments were performed. RESULTS: CLC, PL and SW showed a significant modulation between baseline and response in controls but not in patients. Patients obtained higher CLC and SW at baseline, lower CLC and higher PL at response, and diminished modulation of CLC and SW as compared to controls. In patients, CLC and SW modulation were inversely associated to cognitive performance in executive tasks and directly associated to working memory. Similar patterns were observed in FEPs. CLC and SW during the baseline were inversely associated to their respective modulation magnitudes. CONCLUSIONS: Our results are coherent with a hyper-segregated network at baseline (higher CLC) and a decreased modulation of the functional connectivity during cognition in schizophrenia.
OBJECTIVE: Higher mental functions depend on global cerebral functional coordination. Our aim was to study fast modulation of functional networks in schizophrenia that has not been previously assessed. METHODS: Graph-theory was used to analyze the electroencephalographic (EEG) activity during an odd-ball task in 57 schizophreniapatients (18 first episode patients, FEPs) and 59 healthy controls. Clustering coefficient (CLC), characteristic path length (PL) and small-worldness (SW) were computed at baseline ([-300 0] ms prior to stimulus delivery) and response ([150 450] ms post-stimulus) windows. Clinical and cognitive assessments were performed. RESULTS: CLC, PL and SW showed a significant modulation between baseline and response in controls but not in patients. Patients obtained higher CLC and SW at baseline, lower CLC and higher PL at response, and diminished modulation of CLC and SW as compared to controls. In patients, CLC and SW modulation were inversely associated to cognitive performance in executive tasks and directly associated to working memory. Similar patterns were observed in FEPs. CLC and SW during the baseline were inversely associated to their respective modulation magnitudes. CONCLUSIONS: Our results are coherent with a hyper-segregated network at baseline (higher CLC) and a decreased modulation of the functional connectivity during cognition in schizophrenia.
Authors: Javier Gomez-Pilar; Rodrigo de Luis-García; Alba Lubeiro; Henar de la Red; Jesús Poza; Pablo Núñez; Roberto Hornero; Vicente Molina Journal: Hum Brain Mapp Date: 2018-04-02 Impact factor: 5.038
Authors: Inés Fernández-Linsenbarth; Álvaro Planchuelo-Gómez; Rosa M Beño-Ruiz-de-la-Sierra; Alvaro Díez; Antonio Arjona; Adela Pérez; Alberto Rodríguez-Lorenzana; Pilar Del Valle; Rodrigo de Luis-García; Guido Mascialino; Pedro Holgado-Madera; Rafael Segarra-Echevarría; Javier Gomez-Pilar; Pablo Núñez; Berta Bote-Boneaechea; Antonio Zambrana-Gómez; Alejandro Roig-Herrero; Vicente Molina Journal: Brain Behav Date: 2021-11-10 Impact factor: 2.708
Authors: Javier Gomez-Pilar; Rodrigo de Luis-García; Alba Lubeiro; Nieves de Uribe; Jesús Poza; Pablo Núñez; Marta Ayuso; Roberto Hornero; Vicente Molina Journal: Neuroimage Clin Date: 2018-02-06 Impact factor: 4.881