| Literature DB >> 28336377 |
Peng Mi1, Hironobu Yanagie2, Novriana Dewi2, Hung-Chi Yen3, Xueying Liu4, Minoru Suzuki5, Yoshinori Sakurai5, Koji Ono5, Hiroyuki Takahashi2, Horacio Cabral6, Kazunori Kataoka7, Nobuhiro Nishiyama8.
Abstract
Boron neutron capture therapy is a promising tumor treatment method, though its wide application has been limited due to the poor tumor selectivity and intracellular delivery of 10B-compounds. Here, block copolymer-boron cluster conjugate based on the clinically used sodium borocaptate (BSH) and poly(ethylene glycol)-b-poly(glutamic acid) copolymer have been developed for effectively penetrating tumor tissues and homogeneously delivering the boron clusters into cancer cells towards safe and efficient boron neutron capture therapy. The PEGylated block copolymer-boron cluster (BSH) conjugate has demonstrated significant higher cellular uptake and tumor accumulation when compared to the non-PEGylated formulations and BSH. Moreover, the enhanced delivery to tumors of the conjugates, as well as their superior intratumoral penetration, which facilitated reaching the intracellular space of most cells in tumors, allowed the effective ablation of tumors after neutron irradiation.Entities:
Keywords: Boron neutron capture therapy; Drug delivery system; Polymer-drug conjugate; Sodium borocapate; Tumor penetration
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Year: 2017 PMID： 28336377 DOI： 10.1016/j.jconrel.2017.03.036
Source DB: PubMed Journal: J Control Release ISSN： 0168-3659 Impact factor: 9.776