Qing Wang1, Yibin Guo2, Cheng Wu2, Liang Yin1, Wei Li1, Hua Shen1, Wang Xi1, Tianyi Zhang2, Jia He3, Zhinong Wang4. 1. Center for Comprehensive Treatment of Atrial Fibrillation, Department of Cardiothoracic Surgery, Changzheng Hospital, Second Military Medical University, Shanghai, China. 2. Department of Health Statistics, Second Military Medical University, Shanghai, China. 3. Department of Health Statistics, Second Military Medical University, Shanghai, China. Electronic address: hejia63@yeah.net. 4. Center for Comprehensive Treatment of Atrial Fibrillation, Department of Cardiothoracic Surgery, Changzheng Hospital, Second Military Medical University, Shanghai, China. Electronic address: wangzn007@163.com.
Abstract
BACKGROUND: Although smoking is known to be associated with cardiovascular diseases, the number of large-scale cohort studies on the association between smoking and atrial fibrillation (AF) is limited and the results obtained are also inconsistent, and even fewer studies have addressed the difference between the male and female genders. The present study was intended to clarify and quantify the association between smoking and the risk of AF in men versus women. METHODS: Using AF- and smoking-related keywords, a comprehensive literature search on PubMed, Embase and Web of Science was conducted with a time limit until December 2016, which was followed by manual screening, quality assessment and data extraction. The pooled relative risk (RR) of the included studies was estimated by using the random-effects model. Subgroup, heterogeneity and sensitivity analyses were also conducted. RESULTS: A total of 14 prospective studies and 222,159 individuals were included in this meta-analysis, and the pooled RR of the 14 studies was 1.24 (95% CI, 1.12-1.36; p<0.0001) for the occurrence of AF in smoking populations. The pooled RR in men was 1.38 (95% CI, 1.21-1.57 p<0.0001) versus 1.28 in women (95% CI, 0.93-1.76; p=0.1356). The male-to-female ratio of relative risk (RRR) was 1.17 (95% CI, 0.84-1.63; p=0.3418) of smoking versus non-smoking individuals. CONCLUSION: Smoking is a risk factor for the occurrence of AF. Compared with women, male smokers are more likely to develop AF.
BACKGROUND: Although smoking is known to be associated with cardiovascular diseases, the number of large-scale cohort studies on the association between smoking and atrial fibrillation (AF) is limited and the results obtained are also inconsistent, and even fewer studies have addressed the difference between the male and female genders. The present study was intended to clarify and quantify the association between smoking and the risk of AF in men versus women. METHODS: Using AF- and smoking-related keywords, a comprehensive literature search on PubMed, Embase and Web of Science was conducted with a time limit until December 2016, which was followed by manual screening, quality assessment and data extraction. The pooled relative risk (RR) of the included studies was estimated by using the random-effects model. Subgroup, heterogeneity and sensitivity analyses were also conducted. RESULTS: A total of 14 prospective studies and 222,159 individuals were included in this meta-analysis, and the pooled RR of the 14 studies was 1.24 (95% CI, 1.12-1.36; p<0.0001) for the occurrence of AF in smoking populations. The pooled RR in men was 1.38 (95% CI, 1.21-1.57 p<0.0001) versus 1.28 in women (95% CI, 0.93-1.76; p=0.1356). The male-to-female ratio of relative risk (RRR) was 1.17 (95% CI, 0.84-1.63; p=0.3418) of smoking versus non-smoking individuals. CONCLUSION: Smoking is a risk factor for the occurrence of AF. Compared with women, male smokers are more likely to develop AF.
Authors: Andrew L Walker; Teshia Sorensen; Paolo P Gabriel; Tyler Sledge; Jack H Morshedzadeh; Theophilus Owan; Rashmee U Shah Journal: J Am Coll Clin Pharm Date: 2018-04-14
Authors: Mayank Sardana; Yuanyuan Tang; Jared W Magnani; Ira S Ockene; Jeroan J Allison; Suzanne V Arnold; Phillip G Jones; Thomas M Maddox; Salim S Virani; David D McManus Journal: J Am Heart Assoc Date: 2019-06-28 Impact factor: 5.501