| Literature DB >> 28336142 |
Chi-Ying Li1, I-Wen Lo1, Shih-Wei Wang2, Tsong-Long Hwang3, Yu-Ming Chung1, Yuan-Bin Cheng4, Sung-Pin Tseng5, Yi-Hung Liu6, Yu-Ming Hsu1, Shu-Rong Chen1, Hao-Chun Hu1, Fang-Rong Chang7, Yang-Chang Wu8.
Abstract
A novel nor-betaenone compound, 11-norbetaenone (1), was isolated from the culture broth of an entomopathogenic fungus Lecanicillium antillanum. The structure was determined on the basis of 1D and 2D NMR spectroscopic data. The absolute stereochemistry of 1 was further confirmed by X-ray single crystallography analysis. It is the first secondary metabolite reported from the species Lecanicillium antillanum. And it is also the first time that a betaenone-type compound was isolated from the genus Lecanicillium. Furthermore, 11-norbetaenone (1) displayed significant anti-angiogenic effect by suppressing tube formation.Entities:
Keywords: Anti-angiogenic effect; Betaenone; Lecanicillium antillanum; Polyketide synthase; Secondary metabolite
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Year: 2017 PMID： 28336142 DOI： 10.1016/j.bmcl.2017.03.019
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823