Literature DB >> 28336141

The discovery of potent and selective kynurenine 3-monooxygenase inhibitors for the treatment of acute pancreatitis.

John Liddle1, Benjamin Beaufils2, Margaret Binnie3, Anne Bouillot2, Alexis A Denis2, Michael M Hann4, Carl P Haslam4, Duncan S Holmes4, Jon P Hutchinson4, Michael Kranz4, Andrew McBride3, Olivier Mirguet2, Damian J Mole5, Christopher G Mowat6, Sandeep Pal4, Paul Rowland4, Lionel Trottet2, Iain J Uings4, Ann L Walker4, Scott P Webster3.   

Abstract

A series of potent, competitive and highly selective kynurenine monooxygenase inhibitors have been discovered via a substrate-based approach for the treatment of acute pancreatitis. The lead compound demonstrated good cellular potency and clear pharmacodynamic activity in vivo.
Copyright © 2017 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Kynurenine; Monooxygenase; Pancreatitis; Substrate; Tryptophan

Mesh：

Substances：

Year:  2017        PMID： 28336141     DOI： 10.1016/j.bmcl.2017.02.078

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  6 in total

1.  Structural and mechanistic basis of differentiated inhibitors of the acute pancreatitis target kynurenine-3-monooxygenase.

Authors:  Jonathan P Hutchinson; Paul Rowland; Mark R D Taylor; Erica M Christodoulou; Carl Haslam; Clare I Hobbs; Duncan S Holmes; Paul Homes; John Liddle; Damian J Mole; Iain Uings; Ann L Walker; Scott P Webster; Christopher G Mowat; Chun-Wa Chung
Journal:  Nat Commun       Date:  2017-06-12       Impact factor: 14.919

2.  Diclofenac Identified as a Kynurenine 3-Monooxygenase Binder and Inhibitor by Molecular Similarity Techniques.

Authors:  Steven Shave; Kris McGuire; Nhan T Pham; Damian J Mole; Scott P Webster; Manfred Auer
Journal:  ACS Omega       Date:  2018-03-02

Review 3.  Tryptophan Metabolism via Kynurenine Pathway: Role in Solid Organ Transplantation.

Authors:  Ruta Zulpaite; Povilas Miknevicius; Bettina Leber; Kestutis Strupas; Philipp Stiegler; Peter Schemmer
Journal:  Int J Mol Sci       Date:  2021-02-15       Impact factor: 5.923

4.  Pharmacophore-Based Virtual Screening of Novel Competitive Inhibitors of the Neurodegenerative Disease Target Kynurenine-3-Monooxygenase.

Authors:  Lizaveta Gotina; Seon Hee Seo; Chae Won Kim; Sang Min Lim; Ae Nim Pae
Journal:  Molecules       Date:  2021-05-31       Impact factor: 4.411

5.  A brain-permeable inhibitor of the neurodegenerative disease target kynurenine 3-monooxygenase prevents accumulation of neurotoxic metabolites.

Authors:  Shaowei Zhang; Michiyo Sakuma; Girdhar S Deora; Colin W Levy; Alex Klausing; Carlo Breda; Kevin D Read; Chris D Edlin; Benjamin P Ross; Marina Wright Muelas; Philip J Day; Stephen O'Hagan; Douglas B Kell; Robert Schwarcz; David Leys; Derren J Heyes; Flaviano Giorgini; Nigel S Scrutton
Journal:  Commun Biol       Date:  2019-07-24

Review 6.  Kynurenine-3-monooxygenase: A new direction for the treatment in different diseases.

Authors:  Yifei Lu; Mingmei Shao; Tao Wu
Journal:  Food Sci Nutr       Date:  2020-01-20       Impact factor: 2.863
  6 in total

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