Literature DB >> 2833569

The herpes simplex virus type 1 US7 gene product is a 66K glycoprotein and is a target for complement-dependent virus neutralization.

V Sullivan1, G L Smith.   

Abstract

The US7 open reading frame of herpes simplex virus type 1 (HSV-1), previously identified by nucleotide sequencing, has been expressed in a recombinant vaccinia virus (US7-VAC). Antiserum raised against HSV-1 reacted with a 66K glycoprotein in US7-VAC-infected cells and this polypeptide was present on both nuclear and cell surface membranes. In the presence of tunicamycin the protein was reduced in size to 58K showing it contained N-linked sugar residues. Antisera from animals vaccinated with US7-VAC recognized 66K and 58K polypeptides in HSV-1-infected cells and neutralized HSV-1 infectivity in vitro in the presence of complement.

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Year:  1988        PMID： 2833569     DOI： 10.1099/0022-1317-69-4-859

Source DB:  PubMed          Journal:  J Gen Virol        ISSN： 0022-1317            Impact factor:   3.891


  7 in total

1.  Expression of herpes simplex virus type 1 glycoprotein I in baculovirus: preliminary biochemical characterization and protection studies.

Authors:  H Ghiasi; R Kaiwar; A B Nesburn; S L Wechsler
Journal:  J Virol       Date:  1992-04       Impact factor: 5.103

2.  Application of a transformed cell line constitutively expressing HSV-1 polypeptides for the detection of HSV antibodies in human sera by an enzyme immunoassay.

Authors:  A Sivropoulou; A Vasilaki; M Arsenakis
Journal:  Arch Virol       Date:  1994       Impact factor: 2.574

3.  Induction of immunoglobulin G Fc receptors by recombinant vaccinia viruses expressing glycoproteins E and I of herpes simplex virus type 1.

Authors:  S Bell; M Cranage; L Borysiewicz; T Minson
Journal:  J Virol       Date:  1990-05       Impact factor: 5.103

4.  Coexpression by vaccinia virus recombinants of equine herpesvirus 1 glycoproteins gp13 and gp14 results in potentiated immunity.

Authors:  P X Guo; S Goebel; M E Perkus; J Taylor; E Norton; G Allen; B Languet; P Desmettre; E Paoletti
Journal:  J Virol       Date:  1990-05       Impact factor: 5.103

5.  Expression in recombinant vaccinia virus of the equine herpesvirus 1 gene encoding glycoprotein gp13 and protection of immunized animals.

Authors:  P X Guo; S Goebel; S Davis; M E Perkus; B Languet; P Desmettre; G Allen; E Paoletti
Journal:  J Virol       Date:  1989-10       Impact factor: 5.103

6.  Expression of the Marek's disease virus (MDV) homolog of glycoprotein B of herpes simplex virus by a recombinant baculovirus and its identification as the B antigen (gp100, gp60, gp49) of MDV.

Authors:  M Niikura; Y Matsuura; D Endoh; M Onuma; T Mikami
Journal:  J Virol       Date:  1992-05       Impact factor: 5.103

7.  Discovery and Characterization of an Aberrant Small Form of Glycoprotein I of Herpes Simplex Virus Type I in Cell Culture.

Authors:  Xixi Gui; Wuchao Zhang; Peng Gao; Yongning Zhang; Lei Zhou; Xinna Ge; Xin Guo; John W Wills; Jun Han; Hanchun Yang
Journal:  Microbiol Spectr       Date:  2022-03-29
  7 in total

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