Jaime Gomez-Millan1, Maria Isabel Queipo2, Maria Del Mar Delgado3, Lidia Perez-Villa4, Alicia Roman1, Fernando De la Portilla5, Esperanza Torres6, Vanessa De Luque6, Eloisa Bayo3, Jose Antonio Medina1. 1. Department of Radiation Oncology, University Hospital Virgen de la Victoria, Málaga, Spain. 2. Department of Endocrinology, Biomedical Research Institute (IBIMA), Málaga, Spain. 3. Department of Radiation Oncology, University Hospital Juan Ramón Jiménez, Huelva, Spain. 4. Department of Pathology, University Hospital Virgen de la Victoria, Málaga, Spain. 5. Department of Surgery, Colorectal Surgery, University Hospital Virgen del Rocío, Seville, Spain. 6. Department of Medical Oncology, University Hospital Virgen de la Victoria, Málaga, Spain.
Abstract
BACKGROUND AND OBJECTIVE: We examined the prognostic value of obesity and nuclear β-catenin in patients with locally advanced rectal cancer. METHODS: We prospectively recruited a total of 98 eligible patients with locally advanced cancer for preoperative radiochemotherapy followed by total mesorectal excision. Patients' height and weight were reaorded before radiochemotherapy, and the immunohistochemical expression of nuclear β-catenin was analyzed. Disease-free survival (DFS) was analyzed using the Kaplan-Meier method and a Cox regression model was employed for the multivariate analysis. RESULTS: Obese patients were associated with a lower number of recurrences (3.6% vs. 34.3%, P = 0.001), and a higher DFS (95% vs. 53%; HR, 0.09; 95%CI, 0.01-0.64; P = 0.005) than non-obese patients. In the multivariate analysis, body mass index, nuclear β-catenin expression, and the absence of lymph node metastases showed a significant increase in DFS. CONCLUSIONS: Obesity and nuclear β-catenin are independent favorable prognostic factors for DFS in locally advanced cancer treated with preoperative radiochemotherapy. J. Surg. Oncol. 2017;115:301-306.
BACKGROUND AND OBJECTIVE: We examined the prognostic value of obesity and nuclear β-catenin in patients with locally advanced rectal cancer. METHODS: We prospectively recruited a total of 98 eligible patients with locally advanced cancer for preoperative radiochemotherapy followed by total mesorectal excision. Patients' height and weight were reaorded before radiochemotherapy, and the immunohistochemical expression of nuclear β-catenin was analyzed. Disease-free survival (DFS) was analyzed using the Kaplan-Meier method and a Cox regression model was employed for the multivariate analysis. RESULTS:Obesepatients were associated with a lower number of recurrences (3.6% vs. 34.3%, P = 0.001), and a higher DFS (95% vs. 53%; HR, 0.09; 95%CI, 0.01-0.64; P = 0.005) than non-obesepatients. In the multivariate analysis, body mass index, nuclear β-catenin expression, and the absence of lymph node metastases showed a significant increase in DFS. CONCLUSIONS:Obesity and nuclear β-catenin are independent favorable prognostic factors for DFS in locally advanced cancer treated with preoperative radiochemotherapy. J. Surg. Oncol. 2017;115:301-306.
Authors: Soo Young Lee; Chang Hyun Kim; Young Jin Kim; Han Deok Kwak; Jae Kyun Ju; Hyeong Rok Kim Journal: Ann Surg Treat Res Date: 2018-02-26 Impact factor: 1.859