Yu Liu1, Sha Sun2, Timothy Bredy3, Marcelo Wood3, Robert C Spitale4, Pierre Baldi1. 1. Department of Computer Science and Institute for Genomics and Bioinformatics. 2. Department of Developmental and Cell Biology. 3. Department of Neurobiology and Behavior. 4. Department of Pharmaceutical Sciences and the Chao Family Comprehensive Cancer Center, University of California, Irvine, CA 92697, USA.
Abstract
MOTIVATION: RNA plays a critical role in gene expression and its regulation. RNA binding proteins (RBPs), in turn, are important regulators of RNA. Thanks to the availability of large scale data for RBP binding motifs and in vivo binding sites results in the form of eCLIP experiments, it is now possible to computationally predict RBP binding sites across the whole genome. RESULTS: We describe MotifMap-RNA, an extension of MotifMap which predicts binding sites for RBP motifs across human and mouse genomes and allows large scale querying of predicted binding sites. AVAILABILITY AND IMPLEMENTATION: The data and corresponding web server are available from: http://motifmap-rna.ics.uci.edu/ as part of the MotifMap web portal. CONTACT: rspitale@uci.edu or pfbaldi@uci.edu. SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.
MOTIVATION: RNA plays a critical role in gene expression and its regulation. RNA binding proteins (RBPs), in turn, are important regulators of RNA. Thanks to the availability of large scale data for RBP binding motifs and in vivo binding sites results in the form of eCLIP experiments, it is now possible to computationally predict RBP binding sites across the whole genome. RESULTS: We describe MotifMap-RNA, an extension of MotifMap which predicts binding sites for RBP motifs across human and mouse genomes and allows large scale querying of predicted binding sites. AVAILABILITY AND IMPLEMENTATION: The data and corresponding web server are available from: http://motifmap-rna.ics.uci.edu/ as part of the MotifMap web portal. CONTACT: rspitale@uci.edu or pfbaldi@uci.edu. SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.
Authors: Louis Philip Benoit Bouvrette; Samantha Bovaird; Mathieu Blanchette; Eric Lécuyer Journal: Nucleic Acids Res Date: 2020-01-08 Impact factor: 16.971
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