Literature DB >> 28332949

Public attitudes in Japan towards human-animal chimeric embryo research using human induced pluripotent stem cells.

Tsutomu Sawai1, Taichi Hatta1, Misao Fujita1.   

Abstract

AIM: To understand the steps and objectives for which Japanese people are willing to accept human-animal chimeric embryo research using human induced pluripotent stem cells.
METHODS: An internet-based survey was conducted for the general public and researchers in Japan in 2016.
RESULTS: Over 60% of the public and 83.8% of researchers supported the creation of human-swine chimeras and 81.0% of the public and 92.4% of researchers supported the creation of human-swine chimeric embryos. DISCUSSION: When presented with a graded view of human-swine chimeric embryo research with concomitant, specific objectives, a large majority of the general public as well as researchers are willing to accept this research with the aims of disease study, novel drug and treatment development, and transplantation.

Entities:  

Keywords:  Japan; human-induced pluripotent stem cells; human–animal chimeras; human–animal chimeric embryos; public attitudes; questionnaire survey

Mesh:

Year:  2017        PMID: 28332949     DOI: 10.2217/rme-2016-0171

Source DB:  PubMed          Journal:  Regen Med        ISSN: 1746-0751            Impact factor:   3.806


  7 in total

1.  The Japanese Generally Accept Human-Animal Chimeric Embryo Research but Are Concerned About Human Cells Contributing to Brain and Gametes.

Authors:  Tsutomu Sawai; Taichi Hatta; Misao Fujita
Journal:  Stem Cells Transl Med       Date:  2017-07-11       Impact factor: 6.940

2.  Ethical rejections of xenotransplantation? The potential and challenges of using human-pig chimeras to create organs for transplantation.

Authors:  John D Loike; Alan Kadish
Journal:  EMBO Rep       Date:  2018-07-10       Impact factor: 8.807

3.  A comparative analysis of attitudes toward stem cell research and regenerative medicine between six countries - A pilot study.

Authors:  Ryuma Shineha; Yusuke Inoue; Yoshimi Yashiro
Journal:  Regen Ther       Date:  2022-05-13       Impact factor: 3.651

4.  Public Attitudes toward Human-Animal Chimera Research May Be More Complicated than They Appear.

Authors:  Isabel Bolo; Ben Curran Wills; Karen J Maschke
Journal:  Stem Cell Reports       Date:  2021-02-09       Impact factor: 7.765

5.  Public attitudes in Japan toward the creation and use of gametes derived from human-induced pluripotent stem cells.

Authors:  Tsutomu Sawai; Taichi Hatta; Kyoko Akatsuka; Misao Fujita
Journal:  Future Sci OA       Date:  2021-10-22

Review 6.  Interspecies Chimeric Barriers for Generating Exogenic Organs and Cells for Transplantation.

Authors:  Phoebe Strell; Anala Shetty; Clifford J Steer; Walter C Low
Journal:  Cell Transplant       Date:  2022 Jan-Dec       Impact factor: 4.139

7.  The American Public Is Ready to Accept Human-Animal Chimera Research.

Authors:  Andrew T Crane; Francis X Shen; Jennifer L Brown; Warren Cormack; Mercedes Ruiz-Estevez; Joseph P Voth; Tsutomu Sawai; Taichi Hatta; Misao Fujita; Walter C Low
Journal:  Stem Cell Reports       Date:  2020-10-01       Impact factor: 7.765

  7 in total

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