Literature DB >> 2833221

The effects of structural modifications on the insulin-releasing activity of beta-cell-tropin.

S J Dunmore1, M Panico, A T Etienne, H R Morris, A Beloff-Chain.   

Abstract

The minimal effective concentration of the pituitary insulin secretagogue beta-cell-tropin (beta-CT) on the in vitro perfused pancreas was established and the effects of various modifications of the peptide on its potency were tested: iodination with 127I and acetylation reduced the insulin-releasing activity of beta-cell-tropin, and the C-terminal fragments beta-CT-(2-18), beta-CT-(3-18) and beta-CT-(6-18) were all less potent than the intact molecule; beta-CT-(1-6) was not active and did not inhibit beta-CT-induced insulin release.

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Year:  1987        PMID： 2833221      PMCID： PMC1148067          DOI： 10.1042/bj2440797

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  17 in total

1.  Preparation of iodine-131 labelled human growth hormone of high specific activity.

Authors:  W M HUNTER; F C GREENWOOD
Journal:  Nature       Date:  1962-05-05       Impact factor: 49.962

2.  Influence of the pituitary gland on insulin secretion in the genetically obese (ob/ob) mouse.

Authors:  A Beloff-Chain; J A Edwardson; J Hawthorn
Journal:  J Endocrinol       Date:  1975-04       Impact factor: 4.286

3.  beta-cell tropin, a peptide of the pituitary pars intermedia which stimulates insulin release.

Authors:  A Beloff-Chain; S Dunmore; J Morton
Journal:  FEBS Lett       Date:  1980-08-11       Impact factor: 4.124

4.  A rapid and specific method for the high resolution purification and characterization of neuropeptides.

Authors:  H R Morris; A T Etienne; A Dell; R Albuquerque
Journal:  J Neurochem       Date:  1980-03       Impact factor: 5.372

5.  Evidence for the presence of the pituitary insulin secretagogue beta-cell trophin in human plasma.

Authors:  A Salvatoni; S J Dunmore; J L Morton; A T Etienne; A Beloff-Chain; R R Abraham
Journal:  J Endocrinol       Date:  1986-08       Impact factor: 4.286

6.  Effects of the octapeptide of cholecystokinin on insulin and glucagon secretion in the dog.

Authors:  C M Frame; M B Davidson; R A Sturdevant
Journal:  Endocrinology       Date:  1975-09       Impact factor: 4.736

7.  Evidence that the insulin secretagogue, beta-cell-tropin, is ACTH22-39.

Authors:  A Beloff-Chain; J Morton; S Dunmore; G W Taylor; H R Morris
Journal:  Nature       Date:  1983-01-20       Impact factor: 49.962

8.  Three types of alpha-melanocyte-stimulating hormone: bioactivities and half-lives.

Authors:  D Rudman; B M Hollins; M H Kutner; S D Moffitt; M J Lynn
Journal:  Am J Physiol       Date:  1983-07

9.  Insulin release from the perfused rat pancreas, stimulated by perifusates of the pituitary neurointermediate lobes of genetically obese and lean mice.

Authors:  S Dunmore; A Beloff-Chain
Journal:  J Endocrinol       Date:  1982-01       Impact factor: 4.286

10.  Neural regulation of pancreatic hormone secretion by the C-terminal tetrapeptide of CCK.

Authors:  J F Rehfeld; L I Larsson; N R Goltermann; T W Schwartz; J J Holst; S L Jensen; J S Morley
Journal:  Nature       Date:  1980-03-06       Impact factor: 49.962
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  1 in total

1.  Post-translational modifications of pancreatic fluid proteins collected via the endoscopic pancreatic function test (ePFT).

Authors:  Joao A Paulo; Vivek Kadiyala; Scott Brizard; Peter A Banks; Hanno Steen; Darwin L Conwell
Journal:  J Proteomics       Date:  2013-03-14       Impact factor: 4.044
  1 in total

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