M Backens1. 1. Klinik für Diagnostische und Interventionelle Neuroradiologie, Universitätsklinikum des Saarlandes, Kirrberger Straße 1, 66424, Homburg/Saar, Deutschland. martin.backens@uks.eu.
Abstract
CLINICAL/METHODICAL ISSUE: Magnetic resonance spectroscopy (MRS) is an important non-invasive method that can reveal the concentration and spatial distribution of particular biochemically relevant tissue metabolites. STANDARD RADIOLOGICAL METHODS: Proton MRS is routinely applicable in the clinical setting providing good quality results even with a moderate magnetic field strength of 1.5 T. Relative values of metabolite concentrations are mostly used for the assessment of metabolic disorders. METHODICAL INNOVATIONS: Absolute quantification of metabolites can be achieved by means of internal or external reference scans. Phosphorous MRS extends the range of detectable molecules to energy and cell membrane metabolism. PERFORMANCE: The lower detection limit of metabolite concentrations is in the range of some mmol/kg. Depending on the magnetic field strength, MRS enables a spatial resolution of a few milliliters. ACHIEVEMENTS: The use of phosphorous MRS is considerably limited because higher field strengths of at least 3.0 T and additional expensive hardware for signal processing are required.
CLINICAL/METHODICAL ISSUE: Magnetic resonance spectroscopy (MRS) is an important non-invasive method that can reveal the concentration and spatial distribution of particular biochemically relevant tissue metabolites. STANDARD RADIOLOGICAL METHODS: Proton MRS is routinely applicable in the clinical setting providing good quality results even with a moderate magnetic field strength of 1.5 T. Relative values of metabolite concentrations are mostly used for the assessment of metabolic disorders. METHODICAL INNOVATIONS: Absolute quantification of metabolites can be achieved by means of internal or external reference scans. Phosphorous MRS extends the range of detectable molecules to energy and cell membrane metabolism. PERFORMANCE: The lower detection limit of metabolite concentrations is in the range of some mmol/kg. Depending on the magnetic field strength, MRS enables a spatial resolution of a few milliliters. ACHIEVEMENTS: The use of phosphorous MRS is considerably limited because higher field strengths of at least 3.0 T and additional expensive hardware for signal processing are required.
Authors: Charles Gasparovic; Tao Song; Deidre Devier; H Jeremy Bockholt; Arvind Caprihan; Paul G Mullins; Stefan Posse; Rex E Jung; Leslie A Morrison Journal: Magn Reson Med Date: 2006-06 Impact factor: 4.668
Authors: Thiele Kobus; Alan J Wright; Elisabeth Weiland; Arend Heerschap; Tom W J Scheenen Journal: Magn Reson Med Date: 2014-01-31 Impact factor: 4.668