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Literature DB >> 28331156

Neonatal high-permeability pulmonary edema based on serial cytokine profiles and KL-6 in serum: case report.

Toshihiko Nakamura¹, Mari Nakamura¹, Naoto Takahashi².

Abstract

A newborn male with pulmonary edema was delivered at term by elective Caesarian section.　Cytokine profiles of 17 cytokines and KL-6 in cord blood and serial serum values were investigated. The cord blood values of all 17 cytokines and KL-6 were within normal limits.　Subsequently, IL-6, IL-8, IL-10, IL-13, IL-17, and IFNγ rapidly elevated during the first several hours after birth and dramatically decreased thereafter, whereas KL-6 rose to 611 U/ml on the 3rd day of life and then gradually decreased.　These cytokines may induce pulmonary permeability, and KL-6 secreted in lining fluid could result in influx into the bloodstream.　This is the first report that we have differentiated neonatal pulmonary edema from TTN by the measurement of serial cytokine profiles and KL-6 in serum.

Entities: Disease Gene

Keywords: KL-6; cytokine profiles; high permeability; neonates; pulmonary edema

Mesh：

Substances：

Year: 2017 PMID： 28331156 PMCID： PMC5476821 DOI： 10.5387/fms.2016-8

Source DB: PubMed Journal: Fukushima J Med Sci ISSN： 0016-2590

14 in total

1. Cytokine profiles of seventeen cytokines, growth factors and chemokines in cord blood and its relation to perinatal clinical findings.

Authors: Naoto Takahashi; Ritei Uehara; Mami Kobayashi; Yukari Yada; Yasunori Koike; Ryou Kawamata; Jun Odaka; Yoko Honma; Mariko Y Momoi
Journal: Cytokine Date: 2009-12-29 Impact factor: 3.861

2. Effects of inflammatory cytokines on the permeability of human lung microvascular endothelial cell monolayers and differential eosinophil transmigration.

Authors: Julie B Sedgwick; Indu Menon; James E Gern; William W Busse
Journal: J Allergy Clin Immunol Date: 2002-11 Impact factor: 10.793

3. The effect of fetal acidemia on fetal-placental vascular tone and production of the inflammatory cytokines interleukin-6 and tumor necrosis factor-alpha.

Authors: Brian T Pierce; Peter G Napolitano; Lisa M Pierce; Christine Kovac; Roderick F Hume; Byron C Calhoun
Journal: Am J Obstet Gynecol Date: 2002-10 Impact factor: 8.661

4. IL-6 increases endothelial permeability in vitro.

Authors: N Maruo; I Morita; M Shirao; S Murota
Journal: Endocrinology Date: 1992-08 Impact factor: 4.736

5. Involvement of proton-sensing TDAG8 in extracellular acidification-induced inhibition of proinflammatory cytokine production in peritoneal macrophages.

Authors: Chihiro Mogi; Masayuki Tobo; Hideaki Tomura; Naoya Murata; Xiao-dong He; Koichi Sato; Takao Kimura; Tamotsu Ishizuka; Takehiko Sasaki; Takashi Sato; Yasuyuki Kihara; Satoshi Ishii; Akihiro Harada; Fumikazu Okajima
Journal: J Immunol Date: 2009-03-01 Impact factor: 5.422

6. Increase in interleukin-8 and soluble intercellular adhesion molecule-1 in bronchoalveolar lavage fluid from premature infants who develop chronic lung disease.

Authors: S Kotecha; B Chan; N Azam; M Silverman; R J Shaw
Journal: Arch Dis Child Fetal Neonatal Ed Date: 1995-03 Impact factor: 5.747

Neonatal high-permeability pulmonary edema based on serial cytokine profiles and KL-6 in serum: case report.

1. Cytokine profiles of seventeen cytokines, growth factors and chemokines in cord blood and its relation to perinatal clinical findings.

2. Effects of inflammatory cytokines on the permeability of human lung microvascular endothelial cell monolayers and differential eosinophil transmigration.

3. The effect of fetal acidemia on fetal-placental vascular tone and production of the inflammatory cytokines interleukin-6 and tumor necrosis factor-alpha.

4. IL-6 increases endothelial permeability in vitro.

5. Involvement of proton-sensing TDAG8 in extracellular acidification-induced inhibition of proinflammatory cytokine production in peritoneal macrophages.

6. Increase in interleukin-8 and soluble intercellular adhesion molecule-1 in bronchoalveolar lavage fluid from premature infants who develop chronic lung disease.

7. Noninvasive assessment of myocardial contractility, preload, and afterload in healthy newborn infants.

Review 8. Tailor-made circulatory management based on the stress-velocity relationship in preterm infants.

9. Normal values for KL-6 in cord venous plasma of neonates.

10. Levels of 25 cytokines in the first seven days of life in newborn infants.

1. Tools for assessing lung fluid in neonates with respiratory distress.

2. Diagnostic value of KL-6 in idiopathic interstitial pneumonia.