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Literature DB >> 2833115

Conformational change in plasma albumin due to interaction with isolated rat hepatocyte.

Abstract

The electron spin resonance spectroscopy of 4-isothiocyanato-tempo labeled to bovine serum albumin (BSA) and the absorption spectroscopy of eosin maleimide labeled to BSA in the isolated rat hepatocyte suspension indicate conformational change occurring in the albumin molecule during interaction with the hepatocellular membrane. The conformational change in the albumin molecule may possibly accelerate the dissociation of albumin-organic anion complexes at the surface of the liver cell. The conformational change in the albumin molecule may explain in part the mechanism of albumin-mediated hepatic transport.

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Year: 1988 PMID： 2833115 DOI： 10.1152/ajpgi.1988.254.4.G465

Source DB: PubMed Journal: Am J Physiol ISSN： 0002-9513

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Cited

14 in total

Review 1. Covalent and noncovalent protein binding of drugs: implications for hepatic clearance, storage, and cell-specific drug delivery.

Authors: D K Meijer; P van der Sluijs
Journal: Pharm Res Date: 1989-02 Impact factor: 4.200

2. Species differences of serum albumins: III. Analysis of structural characteristics and ligand binding properties during N-B transitions.

Authors: T Kosa; T Maruyama; N Sakai; N Yonemura; S Yahara; M Otagiri
Journal: Pharm Res Date: 1998-04 Impact factor: 4.200

3. At physiologic albumin/oleate concentrations oleate uptake by isolated hepatocytes, cardiac myocytes, and adipocytes is a saturable function of the unbound oleate concentration. Uptake kinetics are consistent with the conventional theory.

Authors: D Sorrentino; R B Robinson; C L Kiang; P D Berk
Journal: J Clin Invest Date: 1989-10 Impact factor: 14.808

4. Plasma binding and transport of diazepam across the blood-brain barrier. No evidence for in vivo enhanced dissociation.

Authors: R K Dubey; C B McAllister; M Inoue; G R Wilkinson
Journal: J Clin Invest Date: 1989-10 Impact factor: 14.808

10. Pharmacokinetic modeling of the sinusoidal efflux of anionic ligands from the isolated perfused rat liver: the influence of albumin.

Authors: J H Proost; H M Nijssen; C B Strating; D K Meijer; G M Groothuis
Journal: J Pharmacokinet Biopharm Date: 1993-08

Conformational change in plasma albumin due to interaction with isolated rat hepatocyte.

Review 1. Covalent and noncovalent protein binding of drugs: implications for hepatic clearance, storage, and cell-specific drug delivery.

2. Species differences of serum albumins: III. Analysis of structural characteristics and ligand binding properties during N-B transitions.

3. At physiologic albumin/oleate concentrations oleate uptake by isolated hepatocytes, cardiac myocytes, and adipocytes is a saturable function of the unbound oleate concentration. Uptake kinetics are consistent with the conventional theory.

4. Plasma binding and transport of diazepam across the blood-brain barrier. No evidence for in vivo enhanced dissociation.

5. Kinetic analysis of albumin-mediated uptake of warfarin by perfused rat liver.

Review 6. Bile acid transporters: structure, function, regulation and pathophysiological implications.

7. Renal palmitate transport: possible sites for interaction with a plasma membrane fatty acid-binding protein.

Review 8. Bile acid transporters in health and disease.

9. A direct role for serum albumin in the cellular uptake of long-chain fatty acids.

10. Pharmacokinetic modeling of the sinusoidal efflux of anionic ligands from the isolated perfused rat liver: the influence of albumin.