Yaping Zeng1, Hiroki Tateishi2, Rafael Cavalcante2, Erhan Tenekecioglu2, Pannipa Suwannasom3, Yohei Sotomi4, Carlos Collet4, Shaoping Nie5, Hans Jonker6, Jouke Dijkstra7, Maria D Radu8, Lorenz Räber9, Dougal R McClean10, Robert-Jan van Geuns2, Evald H Christiansen11, Therese Fahrni12, Jacques Koolen13, Yoshinobu Onuma2, Nico Bruining2, Patrick W Serruys14. 1. ThoraxCentre, Erasmus Medical Center, Rotterdam, the Netherlands; The Emergency & Critical Care Center of Beijing Anzhen Hospital, Capital Medical University, Beijing, the People's Republic of China. 2. ThoraxCentre, Erasmus Medical Center, Rotterdam, the Netherlands. 3. ThoraxCentre, Erasmus Medical Center, Rotterdam, the Netherlands; Academic Medical Center, Amsterdam, the Netherlands. 4. Academic Medical Center, Amsterdam, the Netherlands. 5. The Emergency & Critical Care Center of Beijing Anzhen Hospital, Capital Medical University, Beijing, the People's Republic of China. 6. Cardialysis BV, Rotterdam, the Netherlands. 7. Division of Image Processing, Department of Radiology, Leiden University Medical Center, Leiden, the Netherlands. 8. ThoraxCentre, Erasmus Medical Center, Rotterdam, the Netherlands; Department of Cardiology, Rigshospitalet, Copenhagen, Denmark. 9. ThoraxCentre, Erasmus Medical Center, Rotterdam, the Netherlands; Department of Cardiology, Bern University Hospital, Bern, Switzerland. 10. Department of Cardiology, Christchurch Hospital, Christchurch, New Zealand. 11. Department of Cardiology, Aarhus University Hospital, Skejby Hospital, Aarhus, Denmark. 12. Department of Cardiology, Swiss Cardiovascular Center, University Hospital, Bern, Switzerland. 13. Cardiology, Catharina Ziekenhuis, Eindhoven, the Netherlands. 14. International Centre for Circulatory Health, Imperial College, London, United Kingdom. Electronic address: patrick.w.j.c.serruys@gmail.com.
Abstract
OBJECTIVES: The aim of this study was to assess calcium growth with fused grayscale intravascular ultrasound (IVUS), IVUS-virtual histology, and optical coherence tomography (OCT) from baseline to 5-year follow-up in patients treated with bioresorbable vascular scaffolds. BACKGROUND: IVUS and OCT have individual strengths in assessing plaque composition and volume. Fusion of images obtained using these methods could potentially aid in coronary plaque assessment. METHODS: Anatomic landmarks and endoluminal radiopaque markers were used to fuse OCT and IVUS images and match baseline and follow-up. RESULTS: Seventy-two IVUS-virtual histology and OCT paired matched cross-sectional in- and out-scaffold segments were fused at baseline and follow-up. In total, 46 calcified plaques at follow-up were detected using the fusion method (33 in-scaffold, 13 out-scaffold), showing either calcium progression (52.2%) or de novo calcifications (47.8%). On OCT, calcification volume increased from baseline to follow-up by 2.3 ± 2.4 mm3 (p = 0.001). The baseline virtual histologic tissue precursors of dense calcium at follow-up were necrotic core in 73.9% and fibrous or fibrofatty plaque in 10.9%. In 15.2%, calcium was already present at baseline. Precursors on OCT were lipid pool in 71.2%, fibrous plaque in 4.3%, and fibrocalcific plaque in 23.9%. CONCLUSIONS: The use of OCT and IVUS fusion imaging shows similar calcium growth in- and out-scaffold segments. Necrotic core is the most frequent precursor of calcification. The scaffold resorption process creates a tissue layer that re-caps the calcified plaques. (Absorb Clinical Investigation, Cohort B [ABSORB B]; NCT00856856).
OBJECTIVES: The aim of this study was to assess calcium growth with fused grayscale intravascular ultrasound (IVUS), IVUS-virtual histology, and optical coherence tomography (OCT) from baseline to 5-year follow-up in patients treated with bioresorbable vascular scaffolds. BACKGROUND: IVUS and OCT have individual strengths in assessing plaque composition and volume. Fusion of images obtained using these methods could potentially aid in coronary plaque assessment. METHODS: Anatomic landmarks and endoluminal radiopaque markers were used to fuse OCT and IVUS images and match baseline and follow-up. RESULTS: Seventy-two IVUS-virtual histology and OCT paired matched cross-sectional in- and out-scaffold segments were fused at baseline and follow-up. In total, 46 calcified plaques at follow-up were detected using the fusion method (33 in-scaffold, 13 out-scaffold), showing either calcium progression (52.2%) or de novo calcifications (47.8%). On OCT, calcification volume increased from baseline to follow-up by 2.3 ± 2.4 mm3 (p = 0.001). The baseline virtual histologic tissue precursors of dense calcium at follow-up were necrotic core in 73.9% and fibrous or fibrofatty plaque in 10.9%. In 15.2%, calcium was already present at baseline. Precursors on OCT were lipid pool in 71.2%, fibrous plaque in 4.3%, and fibrocalcific plaque in 23.9%. CONCLUSIONS: The use of OCT and IVUS fusion imaging shows similar calcium growth in- and out-scaffold segments. Necrotic core is the most frequent precursor of calcification. The scaffold resorption process creates a tissue layer that re-caps the calcified plaques. (Absorb Clinical Investigation, Cohort B [ABSORB B]; NCT00856856).
Authors: Piotr Baruś; Jakub Modrzewski; Karolina Gumiężna; Piotr Dunaj; Marcin Głód; Adrian Bednarek; Wojciech Wańha; Tomasz Roleder; Janusz Kochman; Mariusz Tomaniak Journal: J Clin Med Date: 2022-07-13 Impact factor: 4.964