Michael J A Reid1, Sanjiv M Baxi, Lila A Sheira, Alan L Landay, Edward A Frongillo, Adebola Adedimeji, Mardge H Cohen, Eryka Wentz, Deborah R Gustafson, Daniel Merenstein, Peter W Hunt, Phyllis C Tien, Sheri D Weiser. 1. *Department of Medicine, University of California, San Francisco (UCSF), San Francisco, CA; †Department of Epidemiology and Biostatistics, UCSF, San Francisco, CA; ‡San Francisco General Hospital, Division of HIV, ID and Global Medicine, San Francisco, CA; §Department of Immunology-Microbiology, Rush University, Chicago, IL; ‖Arnold School of Public Health, University of South Carolina, Columbia, SC; ¶Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY; #Department of Medicine, John H. Stroger, Jr. Hospital of Cook County, Chicago, IL; **Women's Interagency HIV Study (WIHS) Data Management and Analysis Center (WDMAC), Johns Hopkins University, Baltimore, MD; ††Department of Neurology, State University of New York - Downstate, Brooklyn; ‡‡Department of Family Medicine, Georgetown University, Washington, DC; and §§San Francisco Veterans Affairs Medical Center, San Francisco, CA.
Abstract
BACKGROUND: A low proportion of CD28CD8 T cells that express CD57 is associated with increased mortality in HIV infection. The effect of increasing body mass index (BMI) changes in the proportion of CD57CD28CD8 T cells among HIV-infected individuals on antiretroviral therapy is unknown. SETTING: In a US cohort of HIV-infected women, we evaluated associations of BMI and waist circumference with 3 distinct CD8 T cell phenotypes: % CD28CD57CD8 T cells, % CD57 of CD28CD8 T cells, and % CD28 of all CD8 T cells. METHODS: Multivariable linear regression analysis was used to estimate beta coefficients for each of 3 T-cell phenotypes. Covariates included HIV parameters (current and nadir CD4, current viral load), demographics (age, race, income, and study site), and lifestyle (tobacco and alcohol use) factors. RESULTS: Of 225 participants, the median age was 46 years and 50% were obese (BMI >30 m/kg). Greater BMI and waist circumference were both associated with higher % CD28CD57CD8 T cells and % CD57 of all CD28CD8 T cells in multivariable analysis, including adjustment for HIV viral load (all P < 0.05). The association between greater BMI and the overall proportion of CD28 CD8 cells in fully adjusted models (0.078, 95% confidence interval: -0.053 to 0.209) was not significant. CONCLUSIONS: In this analysis, greater BMI and waist circumference are associated with greater expression of CD57 on CD28CD8 T cells and a greater proportion of CD57CD28 CD8 T cells. These findings may indicate that increasing BMI is immunologically protective in HIV-infected women. Future research is needed to understand the prognostic importance of these associations on clinical outcomes.
BACKGROUND: A low proportion of CD28CD8 T cells that express CD57 is associated with increased mortality in HIV infection. The effect of increasing body mass index (BMI) changes in the proportion of CD57CD28CD8 T cells among HIV-infected individuals on antiretroviral therapy is unknown. SETTING: In a US cohort of HIV-infectedwomen, we evaluated associations of BMI and waist circumference with 3 distinct CD8 T cell phenotypes: % CD28CD57CD8 T cells, % CD57 of CD28CD8 T cells, and % CD28 of all CD8 T cells. METHODS: Multivariable linear regression analysis was used to estimate beta coefficients for each of 3 T-cell phenotypes. Covariates included HIV parameters (current and nadir CD4, current viral load), demographics (age, race, income, and study site), and lifestyle (tobacco and alcohol use) factors. RESULTS: Of 225 participants, the median age was 46 years and 50% were obese (BMI >30 m/kg). Greater BMI and waist circumference were both associated with higher % CD28CD57CD8 T cells and % CD57 of all CD28CD8 T cells in multivariable analysis, including adjustment for HIV viral load (all P < 0.05). The association between greater BMI and the overall proportion of CD28CD8 cells in fully adjusted models (0.078, 95% confidence interval: -0.053 to 0.209) was not significant. CONCLUSIONS: In this analysis, greater BMI and waist circumference are associated with greater expression of CD57 on CD28CD8 T cells and a greater proportion of CD57CD28CD8 T cells. These findings may indicate that increasing BMI is immunologically protective in HIV-infectedwomen. Future research is needed to understand the prognostic importance of these associations on clinical outcomes.
Authors: Matthew S Freiberg; Chung-Chou H Chang; Lewis H Kuller; Melissa Skanderson; Elliott Lowy; Kevin L Kraemer; Adeel A Butt; Matthew Bidwell Goetz; David Leaf; Kris Ann Oursler; David Rimland; Maria Rodriguez Barradas; Sheldon Brown; Cynthia Gibert; Kathy McGinnis; Kristina Crothers; Jason Sico; Heidi Crane; Alberta Warner; Stephen Gottlieb; John Gottdiener; Russell P Tracy; Matthew Budoff; Courtney Watson; Kaku A Armah; Donna Doebler; Kendall Bryant; Amy C Justice Journal: JAMA Intern Med Date: 2013-04-22 Impact factor: 21.873
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Authors: Julie A Womack; Chung-Chou H Chang; Kaku A So-Armah; Charles Alcorn; Jason V Baker; Sheldon T Brown; Matthew Budoff; Adeel A Butt; Cynthia Gibert; Matthew Bidwell Goetz; John Gottdiener; Stephen Gottlieb; Amy C Justice; David Leaf; Kathleen McGinnis; David Rimland; Maria C Rodriguez-Barradas; Jason Sico; Melissa Skanderson; Hilary Tindle; Russell P Tracy; Alberta Warner; Matthew S Freiberg Journal: J Am Heart Assoc Date: 2014-10-16 Impact factor: 5.501
Authors: J Daniel Kelly; Eugene T Richardson; Michael Drasher; M Bailor Barrie; Sahr Karku; Mohamed Kamara; Katrina Hann; Kerry Dierberg; Allan Hubbard; Christina P Lindan; Paul E Farmer; George W Rutherford; Sheri D Weiser Journal: Am J Trop Med Hyg Date: 2018-03-15 Impact factor: 2.345