Literature DB >> 28327616

Genetic control of autophagy underlies pathogenesis of inflammatory bowel disease.

K G Lassen1,2, R J Xavier1,2,3.   

Abstract

Autophagy contributes to cellular homeostasis in the face of nutrient deprivation and other cellular stresses. Cell type-specific functions for autophagy are critical in maintaining homeostasis at both the tissue level and at the whole-organism level. Recent work has highlighted the ways in which human genetic variants modulate autophagy to alter epithelial and immune responses in inflammatory bowel disease.

Entities:  

Mesh：

Year:  2017        PMID： 28327616      PMCID： PMC6069523          DOI： 10.1038/mi.2017.18

Source DB:  PubMed          Journal:  Mucosal Immunol        ISSN： 1933-0219            Impact factor:   7.313


  139 in total

1.  Polyunsaturated fatty acid saturation by gut lactic acid bacteria affecting host lipid composition.

Authors:  Shigenobu Kishino; Michiki Takeuchi; Si-Bum Park; Akiko Hirata; Nahoko Kitamura; Jun Kunisawa; Hiroshi Kiyono; Ryo Iwamoto; Yosuke Isobe; Makoto Arita; Hiroyuki Arai; Kazumitsu Ueda; Jun Shima; Satomi Takahashi; Kenzo Yokozeki; Sakayu Shimizu; Jun Ogawa
Journal:  Proc Natl Acad Sci U S A       Date:  2013-10-14       Impact factor: 11.205

2.  Crohn's-like colitis, enterocolitis and perianal disease in Hermansky-Pudlak syndrome.

Authors:  D Hazzan; S Seward; H Stock; S Zisman; K Gabriel; N Harpaz; J J Bauer
Journal:  Colorectal Dis       Date:  2006-09       Impact factor: 3.788

3.  The Ubiquitin Ligase Smurf1 Functions in Selective Autophagy of Mycobacterium tuberculosis and Anti-tuberculous Host Defense.

Authors:  Luis H Franco; Vidhya R Nair; Caitlyn R Scharn; Ramnik J Xavier; Jose R Torrealba; Michael U Shiloh; Beth Levine
Journal:  Cell Host Microbe       Date:  2017-09-13       Impact factor: 21.023

4.  Fanconi Anemia Proteins Function in Mitophagy and Immunity.

Authors:  Rhea Sumpter; Shyam Sirasanagandla; Álvaro F Fernández; Yongjie Wei; Xiaonan Dong; Luis Franco; Zhongju Zou; Christophe Marchal; Ming Yeh Lee; D Wade Clapp; Helmut Hanenberg; Beth Levine
Journal:  Cell       Date:  2016-04-28       Impact factor: 41.582

5.  Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43.

Authors:  Kendle M Maslowski; Angelica T Vieira; Aylwin Ng; Jan Kranich; Frederic Sierro; Di Yu; Heidi C Schilter; Michael S Rolph; Fabienne Mackay; David Artis; Ramnik J Xavier; Mauro M Teixeira; Charles R Mackay
Journal:  Nature       Date:  2009-10-29       Impact factor: 49.962

6.  Genetic Coding Variant in GPR65 Alters Lysosomal pH and Links Lysosomal Dysfunction with Colitis Risk.

Authors:  Kara G Lassen; Craig I McKenzie; Muriel Mari; Tatsuro Murano; Jakob Begun; Leigh A Baxt; Gautam Goel; Eduardo J Villablanca; Szu-Yu Kuo; Hailiang Huang; Laurence Macia; Atul K Bhan; Marcel Batten; Mark J Daly; Fulvio Reggiori; Charles R Mackay; Ramnik J Xavier
Journal:  Immunity       Date:  2016-06-07       Impact factor: 31.745

7.  TRIM27 negatively regulates NOD2 by ubiquitination and proteasomal degradation.

Authors:  Birte Zurek; Ida Schoultz; Andreas Neerincx; Luisa M Napolitano; Katharina Birkner; Eveline Bennek; Gernot Sellge; Maria Lerm; Germana Meroni; Johan D Söderholm; Thomas A Kufer
Journal:  PLoS One       Date:  2012-07-19       Impact factor: 3.240

8.  TRIM-mediated precision autophagy targets cytoplasmic regulators of innate immunity.

Authors:  Tomonori Kimura; Ashish Jain; Seong Won Choi; Michael A Mandell; Kate Schroder; Terje Johansen; Vojo Deretic
Journal:  J Cell Biol       Date:  2015-09-14       Impact factor: 10.539

9.  Paneth cells as a site of origin for intestinal inflammation.

Authors:  Timon E Adolph; Michal F Tomczak; Lukas Niederreiter; Hyun-Jeong Ko; Janne Böck; Eduardo Martinez-Naves; Jonathan N Glickman; Markus Tschurtschenthaler; John Hartwig; Shuhei Hosomi; Magdalena B Flak; Jennifer L Cusick; Kenji Kohno; Takao Iwawaki; Susanne Billmann-Born; Tim Raine; Richa Bharti; Ralph Lucius; Mi-Na Kweon; Stefan J Marciniak; Augustine Choi; Susan J Hagen; Stefan Schreiber; Philip Rosenstiel; Arthur Kaser; Richard S Blumberg
Journal:  Nature       Date:  2013-10-02       Impact factor: 49.962

10.  Recruitment of TBK1 to cytosol-invading Salmonella induces WIPI2-dependent antibacterial autophagy.

Authors:  Teresa Lm Thurston; Keith B Boyle; Mark Allen; Benjamin J Ravenhill; Maryia Karpiyevich; Stuart Bloor; Annie Kaul; Jessica Noad; Agnes Foeglein; Sophie A Matthews; David Komander; Mark Bycroft; Felix Randow
Journal:  EMBO J       Date:  2016-07-01       Impact factor: 11.598
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  16 in total

1.  Distinct Tissue-Specific Roles for the Disease-Associated Autophagy Genes ATG16L2 and ATG16L1.

Authors:  Bernard Khor; Kara L Conway; Abdifatah S Omar; Moshe Biton; Adam L Haber; Noga Rogel; Leigh A Baxt; Jakob Begun; Petric Kuballa; John D Gagnon; Kara G Lassen; Aviv Regev; Ramnik J Xavier
Journal:  J Immunol       Date:  2019-08-26       Impact factor: 5.422

2.  Emerging views of mitophagy in immunity and autoimmune diseases.

Authors:  Ye Xu; Jun Shen; Zhihua Ran
Journal:  Autophagy       Date:  2019-04-21       Impact factor: 16.016

3.  Crohn's disease IRGM risk alleles are associated with altered gene expression in human tissues.

Authors:  Teminioluwa A Ajayi; Cynthia L Innes; Sara A Grimm; Prashant Rai; Ryan Finethy; Jörn Coers; Xuting Wang; Douglas A Bell; John A McGrath; Shepherd H Schurman; Michael B Fessler
Journal:  Am J Physiol Gastrointest Liver Physiol       Date:  2018-10-18       Impact factor: 4.052

4.  A non-canonical autophagy-dependent role of the ATG16L1T300A variant in urothelial vesicular trafficking and uropathogenic Escherichia coli persistence.

Authors:  Caihong Wang; Kyle A Bauckman; Adam S B Ross; Jane W Symington; Marianne M Ligon; Gael Scholtes; Akhil Kumar; Hao-Wei Chang; Joy Twentyman; Bisiayo E Fashemi; Ramnik J Xavier; Indira U Mysorekar
Journal:  Autophagy       Date:  2018-11-08       Impact factor: 16.016

Review 5.  Innate Immunity to Intracellular Pathogens: Balancing Microbial Elimination and Inflammation.

Authors:  Gabriel Mitchell; Ralph R Isberg
Journal:  Cell Host Microbe       Date:  2017-08-09       Impact factor: 21.023

Review 6.  Beyond self-eating: The control of nonautophagic functions and signaling pathways by autophagy-related proteins.

Authors:  Ken Cadwell; Jayanta Debnath
Journal:  J Cell Biol       Date:  2017-12-13       Impact factor: 10.539

7.  Boosting mTOR-dependent autophagy via upstream TLR4-MyD88-MAPK signalling and downstream NF-κB pathway quenches intestinal inflammation and oxidative stress injury.

Authors:  Mingxia Zhou; Weimin Xu; Jiazheng Wang; Junkai Yan; Yingying Shi; Cong Zhang; Wensong Ge; Jin Wu; Peng Du; Yingwei Chen
Journal:  EBioMedicine       Date:  2018-08-29       Impact factor: 8.143

8.  Natural variation in the roles of C. elegans autophagy components during microsporidia infection.

Authors:  Keir M Balla; Vladimir Lažetić; Emily R Troemel
Journal:  PLoS One       Date:  2019-04-23       Impact factor: 3.752

Review 9.  Modulating T Cell Responses via Autophagy: The Intrinsic Influence Controlling the Function of Both Antigen-Presenting Cells and T Cells.

Authors:  Seth D Merkley; Cameron J Chock; Xuexian O Yang; James Harris; Eliseo F Castillo
Journal:  Front Immunol       Date:  2018-12-14       Impact factor: 7.561

Review 10.  Emerging Mechanisms of Innate Immunity and Their Translational Potential in Inflammatory Bowel Disease.

Authors:  Daniele Corridoni; Thomas Chapman; Tim Ambrose; Alison Simmons
Journal:  Front Med (Lausanne)       Date:  2018-02-19
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