Weixiang Song1, Yindeng Luo1, Yajing Zhao2, Xinjie Liu1, Jiannong Zhao1, Jie Luo2, Qunxia Zhang3, Haitao Ran3, Zhigang Wang3, Dajing Guo1. 1. Department of Radiology, the Second Affiliated Hospital of Chongqing Medical University, No. 74, Linjiang Rd, Yuzhong District, 400010 Chongqing, China. 2. Department of Ultrasound, the First Affiliated Hospital of Chongqing Medical University, No. 1, Youyi Rd, Yuzhong District, 400016 Chongqing, China. 3. Department of Ultrasound, Institute of Ultrasound Imaging, the Second Affiliated Hospital of Chongqing Medical University, No. 74, Linjiang Rd, Yuzhong District, 400010 Chongqing, China.
Abstract
AIM: The aim of this study was to improve tumor-targeted therapy for breast cancer by designing magnetic nanobubbles with the potential for targeted drug delivery and multimodal imaging. MATERIALS & METHODS: Herceptin-decorated and ultrasmall superparamagnetic iron oxide (USPIO)/paclitaxel (PTX)-embedded nanobubbles (PTX-USPIO-HER-NBs) were manufactured by combining a modified double-emulsion evaporation process with carbodiimide technique. PTX-USPIO-HER-NBs were examined for characterization, specific cell-targeting ability and multimodal imaging. RESULTS: PTX-USPIO-HER-NBs exhibited excellent entrapment efficiency of Herceptin/PTX/USPIO and showed greater cytotoxic effects than other delivery platforms. Low-frequency ultrasound triggered accelerated PTX release. Moreover, the magnetic nanobubbles were able to enhance ultrasound, magnetic resonance and photoacoustics trimodal imaging. CONCLUSION: These results suggest that PTX-USPIO-HER-NBs have potential as a multimodal contrast agent and as a system for ultrasound-triggered drug release in breast cancer.
AIM: The aim of this study was to improve tumor-targeted therapy for breast cancer by designing magnetic nanobubbles with the potential for targeted drug delivery and multimodal imaging. MATERIALS & METHODS: Herceptin-decorated and ultrasmall superparamagnetic iron oxide (USPIO)/paclitaxel (PTX)-embedded nanobubbles (PTX-USPIO-HER-NBs) were manufactured by combining a modified double-emulsion evaporation process with carbodiimide technique. PTX-USPIO-HER-NBs were examined for characterization, specific cell-targeting ability and multimodal imaging. RESULTS:PTX-USPIO-HER-NBs exhibited excellent entrapment efficiency of Herceptin/PTX/USPIO and showed greater cytotoxic effects than other delivery platforms. Low-frequency ultrasound triggered accelerated PTX release. Moreover, the magnetic nanobubbles were able to enhance ultrasound, magnetic resonance and photoacoustics trimodal imaging. CONCLUSION: These results suggest that PTX-USPIO-HER-NBs have potential as a multimodal contrast agent and as a system for ultrasound-triggered drug release in breast cancer.
Entities:
Keywords:
PEGlyated PLGA; magnetic resonance; nanobubble; photoacoustic; target; ultrasound
Authors: Sara Zullino; Monica Argenziano; Shoeb Ansari; Roberta Ciprian; Lucia Nasi; Franca Albertini; Roberta Cavalli; Caterina Guiot Journal: Front Pharmacol Date: 2019-09-11 Impact factor: 5.810